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Doctor insights on: Doxycycline Hyclate Vs Monohydrate

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Dr. Martin Raff
Board Certified, Infectious Disease
51 years in practice
103M people helped
1

1
Is doxycycline monohydrate same as doxycycline hyclate?

Dr. Martin Raff
Board Certified, Infectious Disease
51 years in practice
103M people helped
Is doxycycline monohydrate same as doxycycline hyclate?

Doxycycline: Same active drug, different salt.

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Dr. Christopher Crosby
Board Certified
11 years in practice
93K people helped
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Dr. Christopher Crosby
Board Certified
11 years in practice
93K people helped
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Dr. Hirenkumar Italia
567 doctors shared insights

Vibramycin (Definition)

Vibramycin is a tetracyclic agent which is a kind of serotonin-norepinephrine reuptake inhibiting drug (atypical anti-psychotic ...Read more


Dr. Charles Davant
Board Certified, Family Medicine
44 years in practice
879K people helped
2

2
Can you substitue doxycycline monohydrate for doxycycline hyclate?

Dr. Charles Davant
Board Certified, Family Medicine
44 years in practice
879K people helped

Yes: There shouldn't be a difference in efficacy. ...Read more

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Dr. Christopher Crosby
Board Certified
11 years in practice
93K people helped
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Dr. Christopher Crosby
Board Certified
11 years in practice
93K people helped
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Dr. Marsha Davis
Board Certified, Internal Medicine
23 years in practice
66M people helped
3

3
Can u replace doxycycline hyclate with doxycycline monohydrate?

Dr. Marsha Davis
Board Certified, Internal Medicine
23 years in practice
66M people helped
Can u replace doxycycline hyclate with doxycycline monohydrate?

Yes: The active ingredient is doxycycline. They are linked together with something different that is what makes them different. They both work like doxycycline. ...Read more

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Dr. Jerome Litt
Board Certified, Dermatology
66 years in practice
1M people helped
4

4
Can you exchange doxycycline hyclate with doxycycline monohydrate?

Dr. Jerome Litt
Board Certified, Dermatology
66 years in practice
1M people helped
Can you exchange doxycycline hyclate with doxycycline monohydrate?

DOXYCYCLINES: Many dermatologists i know have found no difference between them. I prescribe either. Results are usually the same for both. ...Read more

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Dr. Christopher Crosby
Board Certified
11 years in practice
93K people helped
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Dr. Susan Rhoads
Board Certified, Family Medicine
33 years in practice
6M people helped
5

5
I am an MD in a tertiary care outpatient Wound Center. Do you have any strong sense whether doxycycline hyclate or monohydrate is clinically superior? I sometimes hear that one leads to less GI discomfort, but I cannot seem to find a definitive source. T

Dr. Susan Rhoads
Board Certified, Family Medicine
33 years in practice
6M people helped
I am an MD in a tertiary care outpatient Wound Center. Do you have any strong sense whether doxycycline hyclate or monohydrate is clinically superior? I sometimes hear that one leads to less GI discomfort, but I cannot seem to find a definitive source.  T

Join us, Dr. Marin!: HI, why don't you join us docs? It's a great community and we can e-mail each other through the interface and talk to peers that we would never meed otherwise. Truly a supportive bunch. When Vibramycin, (d. hyclate) was approved, it touted less GI upset and that supported my scant clinical experience. However, recently, a patient said that he had better acne control with the monohydrate. ...Read more

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Dr. Martin Raff
Board Certified, Infectious Disease
51 years in practice
103M people helped
6

6
Is doxycycline monohydrate as effective for treating chlamydia as doxycycline hyclate?

Dr. Martin Raff
Board Certified, Infectious Disease
51 years in practice
103M people helped

Yes: Just different salts of the same drug. ...Read more

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Dr. Tony Ho
Board Certified, Infectious Disease
9 years in practice
3M people helped
7

7
Which is better for treating malaria?Doxycycline monhydrate or doxycycline hyclate

Dr. Tony Ho
Board Certified, Infectious Disease
9 years in practice
3M people helped

Equivalent: Both are equivalent forms of doxycycline, get whichever version is available at your pharmacy. ...Read more

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Dr. Joseph De Santi
Board Certified, Family Medicine
24 years in practice
726K people helped
8

8
Does doxycycline hyclate 100mg twice daily continue working after completing the 10 day course,and if so, for how long ?

Dr. Joseph De Santi
Board Certified, Family Medicine
24 years in practice
726K people helped
Does doxycycline hyclate 100mg twice daily continue working after completing the 10 day course,and if so, for how long ?

MED KINETICS: Unfortunately medication does not last in the bloodstream beyond a certain time based upon the drug's pharmacokinetics. Beyond the period of time you mentioned this drug will typically only last about 22 hours before it is no longer detectable. ...Read more

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Dr. Heidi Fowler
Board Certified, Psychiatry
20 years in practice
532M people helped
9

9
What is doxycycline hyclate?

Dr. Heidi Fowler
Board Certified, Psychiatry
20 years in practice
532M people helped
Dr. Heidi Fowler
Board Certified, Psychiatry
20 years in practice
532M people helped
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Dr. William Singer
446 doctors shared insights

Vibra Tabs (Definition)

Vibra-Tabs is a tetracyclic agent which is a kind of serotonin-norepinephrine reuptake inhibiting drug (atypical anti-psychotic ...Read more


Dr. Walter Husar
552 doctors shared insights

Doxycin (Definition)

Doxycin is a tetracyclic agent which is a kind of serotonin-norepinephrine reuptake inhibiting drug (atypical anti-psychotic ...Read more


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Dr. Christopher Crosby
Board Certified,
11 years in practice
93K people helped
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