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Can you tell me about the long term side effects from the chemotherapy drugs adriamycin (doxorubicin) and cytoxin?
TWO MAJOR ONES: Adriamycin (doxorubicin) and Cytoxan is a great combination regimen used in breast cancer. The major long term side effects for both of these drugs is secondary leukemias, risk is around 1%. For adriamycin (doxorubicin) there is a concern for cardiotoxicity, but risk rises with cumulative dose. Risk is less than 10%. Patients get an echocardiogram or muga scan prior to therapy to evaluate heart status. Talk to your md. ...Read more
Myocyte damage: Adriamycin ( doxorubicin ) originally derived from bacteria, an antibiotic used in cancer treatment can damage cardiac myocytes by interfering oxygen transport inside the cell , (by decreasing in mitochondrial oxidative phasphorylation ), by simple words choking heart muscle cells. It is dose related.. ...Read more
Several effects: Doxorubicin is a powerful medication used in chemotherapy to treat cancer. Like many chemotherapy drugs, it causes side effects including hair loss. The dose has to be managed carefully to avoid damage to the heart. If you have cancer that requires this medication, your doctor will discuss the risks and benefits in more detail. No one is given this medication unless it's really needed. ...Read more
Adriamycin (doxorubicin): “Doxorubicin HCl is contraindicated in patients with: Severe myocardial insufficiency, Recent (occurring within the past 4–6 weeks) myocardial infarction, Severe persistent drug-induced myelosuppression, Severe hepatic impairment (defined as Child Pugh Class C or serum bilirubin level greater than 5 mg/dL) & Severe hypersensitivity reaction to Doxorubicin HCl including anaphylaxis/” See: ...Read more
Adriamycin (doxorubicin): Doxorubicin is brand name of the generic Adriamycin (doxorubicin). ...Read more
Yes: Acts as an anti-emetic. Very important premedication. ...Read more
It can: It can- but that will depend on the cumulative dose given, your age when receiving the treatment, whether you also received other kind of therapy? Radiation etc. Please discuss your situation with your oncologist. ...Read more
Reduce toxicity with: Fortunately I have not had to use it personally but some of my patients have.Doxorubicin can cause nausea, vomiting, low white blood cell count & hair loss, but the most serious side effect is serious heart failure.There is evidence that taking vit c, e, b2, coq10, carnitine and melatonin can protect against cardiotoxicity while enhancing effectiveness! i strongly advise taking these. See comment:. ...Read more
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Adriamycin is a very effective drug and is widely used in oncology.
It does have some serious side effects but they can be manged quite well except for Hair loss. It can cause nausea and vomiting(but it can be easily controlled with anti-nausea medication. It can also affect the heart but your oncologist will take due precuations ...Read more
Adriamycin (doxorubicin): Yes, Adriamycin (doxorubicin) requires a prescription.Get a more detailed answer ›
I shall try: Both drugs are being used in osteosarcoma. Each has its own benefits and side effects. It is a balance beween benefits and risks. Drug combinations areusually used. Age and order of use (1st-round or 2nd) are important factors. Protocols based on national standards are routinely followed. Thank yu for asking. Consult with your cancer doctors. ...Read more
Both drugs: Are . 40 years of use. Vincristine, a vinca alkaloid, inhibits the mitotic spindle needed to draw chromosomes apart during cell division. Cancer cells divide more often. Adria intercalates between dna strands preveneting replication and trtanscription: reading dna to make new stuff. ...Read more
Why is adriamycin (doxorubicin) chemotherapy pushed manually rather than administered through an iv? Are premeds given with a/c chemo? If so what are they?
It is IV: ...Just given as an IV push instead of an IV drip to reduce, amongst other things, the risk of leakage to surrounding tissues leading to a chemical burn. The choice depends on the particular institution and the chemo protocol. As to premeds, most people use zofran (ondansetron) or one of its cousins plus steroids. Many use emend as well right from the start. If this is about you, best wishes. ...Read more
Yes: Doxorubicin (adriamycin (doxorubicin)) can indeed cause nerve damage, but not always the typical 'peripheral neuropathy' seen with other chemotherapy drugs. It affects the myelin sheath of nerve and ganglia and can cause 'ganglionopathy'. Symptoms include numbness/tingling in both the arms/hands and legs/feet (not just the feet). Other drugs given alongside adriamycin (doxorubicin) can add to the risk. ...Read more
Rarely affects it.: Chemotherapy when given over a prescribed period of time such as in the neoadjuvant setting or post surgery rarely effects fertility. In the presence of metastatic disease where long term therapy is given then there is a chance of infertility. This can be true when doxorubicin and Ifex (ifosfamide) are employed for advanced metastatic sarcoma. ...Read more
Heart damage: Adriamycan can cause damage to the heart tissue. It also lowers blood counts which can lead to life threatening infections. Your oncologist can explain how to prevent these problems. ...Read more
Intolerance: A person is considered to have allergy to a medication if there is a sudden reaction(unexpected). The reactions to medicines typically manifest as a skin hives or a skin rash often associated WITH ITCHING. A drop in blood pressure and difficulty with breathing can also occur with severe forms of allergy called Anaphylaxis ...Read more
Was on Taxol and didn't work now going on doxil (liposomal doxorubicin) is that......Going to help?
Chemotherapy: To start with Taxol or Doxil (liposomal doxorubicin) does not make difference but if you fail Taxol you could get a response with Doxil (liposomal doxorubicin) for sure. ...Read more
Hair loss: Are you going to get more cycles of chemo? If not, your hair will start growing within several weeks in general. Be patient. It will grow. ...Read more
Dose dependent: Drugs in this class are known to have risks for inducing damage to heart muscle and consequently impair function to the point of heart failure. This risk rises with cumulative dosing, depending on body size. Baseline and serial assessment of heart function by echo and nuclear studies and tracking of dosing may reduce risk. ...Read more