Doctor insights on:
Doxorubicin Hydrochloride Medication
Can you tell me about the long term side effects from the chemotherapy drugs adriamycin (doxorubicin) and cytoxin?
TWO MAJOR ONES: Adriamycin (doxorubicin) and Cytoxan is a great combination regimen used in breast cancer. The major long term side effects for both of these drugs is secondary leukemias, risk is around 1%. For adriamycin (doxorubicin) there is a concern for cardiotoxicity, but risk rises with cumulative dose. Risk is less than 10%. Patients get an echocardiogram or muga scan prior to therapy to evaluate heart status. Talk to your md. ...Read more
Chemotherapy for SS: I would potentially seek out an opinion from the mayo clinic oncology department who are not very far north of you. I can help set that up for you. Please contact me at David. Stockman@orthopath. Com ...Read more
Adriamycin (doxorubicin): “Doxorubicin HCl is contraindicated in patients with: Severe myocardial insufficiency, Recent (occurring within the past 4–6 weeks) myocardial infarction, Severe persistent drug-induced myelosuppression, Severe hepatic impairment (defined as Child Pugh Class C or serum bilirubin level greater than 5 mg/dL) & Severe hypersensitivity reaction to Doxorubicin HCl including anaphylaxis/” See: ...Read more
Adriamycin (doxorubicin): Doxorubicin is brand name of the generic Adriamycin (doxorubicin). ...Read more
It can: It can- but that will depend on the cumulative dose given, your age when receiving the treatment, whether you also received other kind of therapy? Radiation etc. Please discuss your situation with your oncologist. ...Read more
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Adriamycin is a very effective drug and is widely used in oncology.
It does have some serious side effects but they can be manged quite well except for Hair loss. It can cause nausea and vomiting (but it can be easily controlled with anti-nausea medication. It can also affect the heart but your oncologist will take due precuations ...Read more
Adriamycin (doxorubicin): Yes, Adriamycin (doxorubicin) requires a prescription.Get a more detailed answer ›
Why is adriamycin (doxorubicin) chemotherapy pushed manually rather than administered through an iv? Are premeds given with a/c chemo? If so what are they?
It is IV: ...Just given as an IV push instead of an IV drip to reduce, amongst other things, the risk of leakage to surrounding tissues leading to a chemical burn. The choice depends on the particular institution and the chemo protocol. As to premeds, most people use zofran (ondansetron) or one of its cousins plus steroids. Many use emend as well right from the start. If this is about you, best wishes. ...Read more
Yes: Doxorubicin (adriamycin (doxorubicin)) can indeed cause nerve damage, but not always the typical 'peripheral neuropathy' seen with other chemotherapy drugs. It affects the myelin sheath of nerve and ganglia and can cause 'ganglionopathy'. Symptoms include numbness/tingling in both the arms/hands and legs/feet (not just the feet). Other drugs given alongside adriamycin (doxorubicin) can add to the risk. ...Read more
Heart damage: Adriamycan can cause damage to the heart tissue. It also lowers blood counts which can lead to life threatening infections. Your oncologist can explain how to prevent these problems. ...Read more
Intolerance: A person is considered to have allergy to a medication if there is a sudden reaction (unexpected). The reactions to medicines typically manifest as a skin hives or a skin rash often associated WITH ITCHING. A drop in blood pressure and difficulty with breathing can also occur with severe forms of allergy called Anaphylaxis ...Read more
Yes it can be done: These 3 drugs have been use din combination in the past. Not a great combination in general but it can be done. ...Read more
ER: If you are short of breath, go to the ER by getting a ride or dial 911 and get an ambulance. ...Read more
Hx ILC, tx high dose Adriamycin/Cytoxan 2006. Now, fatigue, difficult swallow, CT scan = one tonsil & lymph nodes in neck enlarged. Risk lymphoma?
Myocyte damage: Adriamycin (doxorubicin) originally derived from bacteria, an antibiotic used in cancer treatment can damage cardiac myocytes by interfering oxygen transport inside the cell, (by decreasing in mitochondrial oxidative phasphorylation), by simple words choking heart muscle cells. It is dose related.. ...Read more
Several effects: Doxorubicin is a powerful medication used in chemotherapy to treat cancer. Like many chemotherapy drugs, it causes side effects including hair loss. The dose has to be managed carefully to avoid damage to the heart. If you have cancer that requires this medication, your doctor will discuss the risks and benefits in more detail. No one is given this medication unless it's really needed. ...Read more
Reduce toxicity with: Fortunately I have not had to use it personally but some of my patients have. Doxorubicin can cause nausea, vomiting, low white blood cell count & hair loss, but the most serious side effect is serious heart failure.There is evidence that taking vit c, e, b2, coq10, carnitine and melatonin can protect against cardiotoxicity while enhancing effectiveness! I strongly advise taking these. See comment:. ...Read more
I shall try: Both drugs are being used in osteosarcoma. Each has its own benefits and side effects. It is a balance beween benefits and risks. Drug combinations areusually used. Age and order of use (1st-round or 2nd) are important factors. Protocols based on national standards are routinely followed. Thank yu for asking. Consult with your cancer doctors. ...Read more
Yes: Acts as an anti-emetic. Very important premedication. ...Read more