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Doctor insights on: Down Syndrome Maternal Age Chart

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What does maternal age have to do with the possibility of down syndrome?

What does maternal age have to do with the possibility of down syndrome?

Statistical risks: The risks of DS are at the low point in the early twenties, (~1/2700) and climb past 1/100 at 45 and over 1/20 after 55. The usual explanation is the accumulated toxic events of a woman's life can cause the eggs that sit in her ovary to become damaged as they age. ...Read more

Dr. Kathryn Akin
641 doctors shared insights

Down Syndrome (Definition)

Down syndrome is the classic presentation clinically of the congenital malformation syndrome also known as Trisomy 21. Classic features may include simian creases, epicanthal folds, upslanting palpebral fissures, flat nasal bridge, hypertelorism, low set ears, endocardial cushion defects of the heart, atlanto-axial joint instability, blood ...Read more


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Why would maternal age be associated with an increase in errors that lead to down syndrome?

Why would maternal age be associated with an increase in errors that lead to down syndrome?

A woman's eggs are : as old as she is. An embryo receives ½ it's chromosomes from Dad & ½ from Mom. DNA replicates in each parental chromosome pair & crosses over between 2 sister chromatids joined in the center that then split into egg cells. At 35 & >, cohesion of maternal sister chromatids is progressively impaired, ^ing the risk of an egg's receiving 2 or 0 copies of a chromosome. Her 2 + Dad's 1 Chr. 21 = DS ...Read more

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Is it normal to have extra ultrasounds due to "advanced maternal age"?

Is it normal to have extra ultrasounds due to "advanced maternal age"?

Yes: Advanced maternal age (age above 35 years old) is considered "high risk pregnancy. These pregnancies are monitored more closely than non high risk pregnancies, including more frequent ultrasounds. ...Read more

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What could cause trisomy 21? Other than translocation? And maternal age?

What could cause trisomy 21? Other than translocation? And maternal age?

Nondisjunction risk: You mentioned the two known risk factors for trisomy 21. Increasing maternal age has an increased risk of nondisjunction (the failure of homologous chromosomes to separate during and after meiosis). This leads to an extra copy of chromosome 21 in the egg. There are probably genetic mutations that lead to increased nondisjunction, but these have not been discovered yet. ...Read more

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Can you tell me about pregnancy and advanced maternal age at 35?

Can you tell me about pregnancy and advanced maternal age at 35?

AMA - age >35: Advanced maternal age (AMA) refers to women who get pregnant and give birth at the age of 35 or elder. AMA has been associated with certain adverse maternal and perinatal outcomes. At age 35 or greater, you have a higher risk of having a fetus with a chromosome anomaly ( i.e. Down Syndrome). There is also an increased risk of pregnancy complications such as gestational diabetes, and preeclampsia. ...Read more

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In spina bifida is there a link to family ntds or do they just come with maternal age?

In spina bifida is there a link to family ntds or do they just come with maternal age?

Some link: There is a genetic link to neural tube defects but is poorly understood. We know the incidence is higher in maternal age, decreased Folic Acid intake, and first generation relatives with neural tube defects. Otherwise, it's not well understood. ...Read more

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What are the risks of getting pregnant or having a baby at a specific maternal age?

What are the risks of getting pregnant or having a baby at a specific maternal age?

Some fixed/some vary: Some pregnancy risks are specific to a couples family tree.All pregnancies have ~ 4% risk of an unexpected outcome, from clefts to prematurity & others. The risk of a chromosome is lowest in the early 20's (~1/1700) & rises to 1/100 @ 40 & 1/50 >45. I encourage those with the question to seek out a geneticist @ a children's hospital or medical school for the a review of personal risk. ...Read more

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Is maternal age still a factor for miscarriage when donor eggs are used?

Is maternal age  still a factor for miscarriage when donor eggs are used?

No.: As you can see from the attached curve, fertility rates depend on the age of the egg donor - not the age of the uterus. Take Folic Acid 1-5 mg daily and best of luck. ...Read more

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Am 31yrs old, was 15wks when did my quad screening&it came back negative, saying its 1:131 for ds, 1:630 for maternal age.What does that mean?

Am 31yrs old, was 15wks when did my quad screening&it came back negative, saying its 1:131 for ds, 1:630 for maternal age.What does that mean?

Double check: Usually a quadruple screen is reported positive if the risk comes back higher than 1 in 250, which is the risk of down's syndrome for a pregnancy woman 35 years of age. For your age, the average risk of down's syndrome is being reported at 1 in 630. ...Read more