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Doctor insights on: Doubling Time Sclc

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What would be a mean time between experiencing paraneoplastic symptoms of sclc LEMS until a tumor would be visible on CT. Is it weeks, months, years?

What would be a mean time between experiencing paraneoplastic symptoms of sclc LEMS until a tumor would be visible on CT. Is it weeks, months, years?

SCLC - small cell: Lambert-Eaton Myasthenic Syndrome (LEMS) is an illness associated with proximal muscle weakness, depressed tendon reflexes, posttetanic potentiation, and autonomic changes. In 40% of patients with LEMS, cancer is present when the weakness begins or is found later. Clinical manifestations frequently precede cancer identification. In most cases, the cancer is discovered within the first 2 years ...Read more

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How long does a person with stage 5 sclc have to live?

How long does a person with stage 5 sclc have to live?

No stage 5 sclc: (sclc)small cell lung cancer is staged as 'limited' or 'extensive'. Although frequently responsive to chemotherapy with platinum & topoisomerase inhibitors, survival is still generally poor for extensive stage sclc. ...Read more

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Is the primary tumor in sclc hard to find and does this mean it isn't diagnosed until spread to lymphs even if symptomatic before lymphs enlarge?

Is the primary tumor in sclc hard to find and does this mean it isn't diagnosed until spread to lymphs even if symptomatic before lymphs enlarge?

Small cell lung CA: It's not so much that it's small; it's that it's extremely aggressive. At autopsy, I've found folks with ten or twenty pounds of metastases around the body, and the lung primary (easy to spot as it's got a typical apperance) is the size of my fingernail. Rarely, a paraneoplsatic syndrome like Ehlers-Danlos can prompt imaging that spots a tiny tumor early. So I think you're right. Best wishes. ...Read more

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Is the primary tumor in sclc hard to visualize on imaging? If so does this mean it is cancer of unknown primary if you can find it only in lymph node

Is the primary tumor in sclc hard to visualize on imaging? If so does this mean it is cancer of unknown primary if you can find it only in lymph node

See below: The primary tumor for small cell lung cancer is usually easy to visualize on CT scan. If it is SCLC, that is the primary type. Often, the cancer develops in lymph nodes and if there is no primary tumor, only enlarged nodes, this is likely the primary site. ...Read more

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Diagnosed sclc, brain MRI clear but eyesight has deteriorated. Is reduced eyesight caused by small cell. Thanks.

Diagnosed sclc, brain MRI clear but eyesight has deteriorated. Is reduced eyesight caused by small cell. Thanks.

Not generally: Small cell lung cancer (SCLC), while generally a serious diagnosis, wasn't thought to affect the eyes. (The bones & brain are still the most common sites of metastasis (spread)). Eye metastasis is STILL VERY RARE in SCLC, but cases have been described in medical literature. Normally it causes VISION LOSS NOT BLURRING as it affects the choroid, the part of the eye w/ most blood vessels. TTY Oncolog ...Read more

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Any radiologist know why PET scans are not approved by medicare for evaluation of SCLC but is for NSCLC. Does it mean they don't visualize sclc well?

Any radiologist know why PET scans are not approved by medicare for evaluation of SCLC but is for NSCLC. Does it mean they don't visualize sclc well?

No effect on treatme: PET scan has no role in diagnosis of SCLC (or NSCLC, for that matter). Any lung cancer has to be diagnosed by biopsy. SCLC is of 2 types: limited (in 1 lung) or diffuse. The prognosis & treatment for these two types are different. The reason why Medicare does not approve PET scan is that treatment does NOT depend on what a PET scan shows. Since it PET doesn't change anything, they won't pay for it ...Read more

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3 years of non specific symptoms then diagnosis of small cell lung cancer. What is likelihood of 3 year of symptoms relating to sclc? Thank you.

3 years of non specific symptoms then diagnosis of small cell lung cancer. What is likelihood of 3 year of symptoms relating to sclc? Thank you.

Zero: I'm sorry about your cancer. Small-cell grows very fast, usually from nothing, and folks typically remember symptoms beginning days or a few weeks before diagnosis. The cough, weight loss, and malaise that may herald this illness are also those of emphysema from the smoking that usually causes small-cell. I hope you get effective treatment and with today's Rx perhaps great luck. ...Read more

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What is the chance I may have SCLC with a left lower lobe pulm nodule 5mm with a clear tracheobronchial tree. Positive anti-VGKC paraneoplastic test.

What is the chance I may have SCLC with a left lower lobe pulm nodule 5mm with a clear tracheobronchial tree. Positive anti-VGKC paraneoplastic test.

Very unlikely: I'm uncertain of the significance of the positive anti-VGKC test but I suspect it can be positive in the absence of a neoplasm. The likelihood of a nodule being malignant can be stratified by your age and the size of the nodule. LIKELIHOOD OF CA BY AGE: 35-39=3%, 40-49=15%, 50-59=43%, >60= 50%. LIKELIHOOD OF CA BY SIZE: <5mm =-<1%, 5-9mm =2-6%, 8-20mm =18%, >20mm =>50% chance of CA ...Read more

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Friend has stage 4 sclc n nsclc currently under radiation suddenly his arm feels foreign, radiation doc blew it off, concern?

Friend has stage 4 sclc n nsclc currently under radiation suddenly his arm feels foreign, radiation doc blew it off, concern?

Ask his doctor: Lung cancer frequently spreads to the brain. This patient might already have it in the brain (the fact he is getting radiation being given now...? Which part of the body). Brain involvemnt by lung cancer can cause loss of limb function. Which should not be a surprise. ...Read more

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What are some cancers that would present with a normal complete blood count? Would sclc and/or testicular cancer present with normal cbc?

What are some cancers that would present with a normal complete blood count? Would sclc and/or testicular cancer present with normal cbc?

Most: Most cancers do not necessarily affect your cbc. Exceptions include hematologic malignancies like leukemia and myeloma. Sclc and testicular cancer are not typically associated with CBC abnormalities. ...Read more

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Should a Dr take action to have a driver's license removed for a 65m with sclc with 3 tumours in Brain including brain stem and frontal lobe?

Should a Dr take action to have a driver's license removed for a 65m with sclc with 3 tumours in Brain including brain stem and frontal lobe?

It depends: Patients with brain tumors are at risk for having Seizures but not all of them develop seizures. About one in 4 patients does. In such patients it is dangerous to drive an automobile. In others it is optional. The doctor can only educate the patient about the risks but the family and the paient has to use their judgement and be responsible for self and public safety. ...Read more

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How long will my 74 year old father live with sclc metastic to brain with immobility set in before he called for help? Doing 15 radiations

How long will my 74 year old father live with sclc metastic to brain with immobility set in before he called for help? Doing 15 radiations

Less then 6 months: The prognosis for small cell lung cancer metastatic to the brain is typically poor. Most patients live less then 2 months, though it can significantly vary depending on performance status, extent of disease (is it metastatic to the liver or bones), tolerance to therapy including brain radiation, then response to chemotherapy. ...Read more

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My mother has been recently diagnosed with SCLC that has spread to the lymphatic system and her bones. What is the general life expectancy?

My mother has been recently diagnosed with SCLC that has spread to the lymphatic system and her bones. What is the general life expectancy?

Life Expectancy: Let me first express my sorrow at the diagnosis that your Mother has received. It is so stressful to see your mother ill and to face the possibility of her death. There are so many factors that have to be considered when you try to come up with a prognosis. These include her general health otherwise, her strength, her mental health, her nutritional state, etc. Her physicians would know best. ...Read more

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My 95 yr old mother diagnosed with SCLC. She does not want any treatment. Path report said Grade 3. what does that mean? Life expectancy?

My 95 yr old mother diagnosed with SCLC. She does not want any treatment. Path report said Grade 3. what does that mean? Life expectancy?

Poor prognosis: Small cell lung cancer is an aggressive malignancy. Grade III refers to how abnormal-looking the cancer cells are. Grade III is quite abnormal. Broadly speaking, there are two stages of the disease: limited to the chest, and extensive (beyond the chest). AVERAGE life expectancy without treatment is a matter of months. I recommend she consult an oncologist. Some oral therapy might help. ...Read more

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Radiology - in sclc is the primary tumor normally difficult to see on a CT scan? Heard that often only spread to nodes can be seen. Pet scan better?

Radiology - in sclc is the primary tumor normally difficult to see on a CT scan? Heard that often only spread to nodes can be seen. Pet scan better?

Small Cell Lung Ca: SCLC does metastasize early, often to nodes, which are often the presenting finding. Usu. The primary tumor is small even though symptoms have occurred.
CT has very high resolution so it has the best chance to find it, esp. If pt. Has been followed with serial screening CTs based on risk factors like smoking history.
PET is useful to find mets, but not a small primary.
...Read more

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My 74 year old father has stage four sclc metastic to multiple areas of the brain. He didn't call for help until he was immobile. Doc says 2 months?

My 74 year old father has stage four sclc metastic to multiple areas of the brain. He didn't call for help until he was immobile. Doc says 2 months?

It is just a guess..: I am sorry to hear of father being so ill. Based on the info your provided, he is indeed quite ill--the condition is very advanced and treatments won't be easy. When a doc provides a "time-to-live" is only an estimate based on similar conditions of other patients he/she had seen or reported in the literature. He may survive longer or shorter. Best is work with his doc and make plans. Good luck. ...Read more

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Endocrine issues + fatigue. Clear CT scan in Apr15. Symptoms persisted CT scan in Feb 16 clear. Could CT be missing SCLC. Is repeat scan necessary?

Endocrine issues + fatigue. Clear CT scan in Apr15. Symptoms persisted CT scan in Feb 16 clear. Could CT be missing SCLC. Is repeat scan necessary?

By SCLC, I presume: You mean small cell lung cancer...a type of lung cancer that is aggressive and is a neuroendocrine tumor which can produce ectopic hormones. But it certainly wouldn't be the first thing you would think of if you have "endocrine issues." The thyroid, pituitary, adrenal glands need full evaluation as well as other work-up. If lung CT "clear" would not pursue SCLC as cause. Best wishes:) ...Read more

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Due to positive anti-vgkc Dr. Ordered a CT lung scan to rule out sclc or thymona. CT found a 5mm nodule. Should I be worry for sclc n ask for testing?

Here is what I would: Your doctor did a test which may not have been indicated. But now thta he has done it AND FOUND SOMETHING WORRISOME TO YOU, HE/SHE MUST COUNSEL YOU AND GUIDE YOU FURTHER. EXCESSIVE TESTING LEADS TO MORE PROBLEMS WHICH LEADS TO MORE TESTING. IN ORDER TO BREAK THE CYCLE, I WOULD MONITOR WITHOUT FURTHER TESTING RIGHT NOW. BUT A REPEAT CT SCAN (OR CHEST X-RAY) IN 6 MONTHS FROM NOW, MAY BE USEFUL. ...Read more

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Imaging - is contrast enhanced ct useful for finding early small cell lung cancer? I understand low dose ct is not good for early sclc is this true?

Imaging - is contrast enhanced ct useful for finding early small cell lung cancer? I understand low dose ct is not good for early sclc is this true?

You need a good Doct: You are getting too deep into medical areas which are beyond your comprehension. You will benefit from seeing a medical doctor (Internist) who can counsel you and guide you further by educating you about your health concerns which appear to be way beyond reason. ...Read more

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Can small cell lung cancer cause malabsorption through zolinger Ellison syndrome. Would this be a presenting sign of sclc before it shows on ct scan?

Can small cell lung cancer cause malabsorption through zolinger Ellison syndrome. Would this be a presenting sign of sclc before it shows on ct scan?

Uncommon: Most Zollinger-Ellison / gastrinoma are from islet cell tumors of the foregut. Oat cell carcinoma can produce other paraneoplastic syndromes, famously the anti-nerve cell ones, before being visible on chest ray, but it announces itself fast enough. And what are you going to without a localized tumor? Take out both lungs? Look for some other cause for any suggestive symptoms. Good question Gill. ...Read more

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Neurologist or oncologist for paraneoplastic neurological syndrome? Maybe sclc? -smoked 10yr. Now: dysesthesias, fatigue, cold/heat intolerant, no hunger.

Neurologist or oncologist for paraneoplastic neurological syndrome? Maybe sclc? -smoked 10yr. Now: dysesthesias, fatigue, cold/heat intolerant, no hunger.

See neurologist: Neurologists deal with these things. There are blood tests which can some times help figure these things out. ...Read more

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Fatigue 1 year, muscle loss but central weight gain, low sodium (135), cortisol at top of range, could this be an early stage sclc. CT was negative.

Fatigue 1 year, muscle loss but central weight gain, low sodium (135), cortisol at top of range, could this be an early stage sclc. CT was negative.

Yes - but very rare: B"sd do you mean small cell lung cancer? Elevated cortisol can be related to stress or to pituitary, adrenal or rarely, ectopic ACTH as in lung cancer. The best screening test is late night salivary cortisol (or a blood cortisol - but this is inconvenient in late PM). Normal cortisol is highest in the AM and close to zero late in the day. This is complicated. Glad to discuss. ...Read more