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Doctor insights on: Double Stranded Dna Lupus Tests

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I had a negative ANA test but positive double stranded DNA test do I have lupus?

I had a negative ANA test but positive double stranded DNA test do I have lupus?

Not enough data: The diagnosis of luppus is made on the basis of clinical signs and symptoms confirmed by specific lab tests including the dna antibody. This antibody can also be positive in other auto immune diseases. Since you did not mention symptoms, there is no way to answer your question. ...Read more

Dna (Definition)

Dna are the coding molecules found in all living things on earth which contain the instructions on how to build living things. Its is comprised the nucleotide molecules which are ...Read more


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What definitive lab test can r/o or confirm lupus while prego? + hashimotos, also + ana, +double stranded DNA. How do I determine a true yes or no?

What definitive lab test can r/o or confirm lupus while prego? + hashimotos, also + ana, +double stranded DNA. How do I determine a true yes or no?

See details: First of all, see a rheumatologist if you have not done so already. While an ANA can often be positive in hashimoto's it is much more unusual for the dna to be positive. Since you do not list your symptoms, it is impossible to offer a more specific opinion. ...Read more

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Just diagnosed with lupus due to double stranded dna. My ch50 was 350 though. Usually this is low in lupus. What could this mean?

Just diagnosed with lupus due to double stranded dna. My ch50 was 350 though. Usually this is low in lupus. What could this mean?

See rheumatologist: Serologic lab results in patients suspected as having lupus can be tricky to interpret. If you have not done so already, see a rheumatologist for a full evaluation. He/she can review your entire picture including the history and physical and can discuss the significance of the various lab tests. ...Read more

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Is it possible that a person have lupus and CNS symptoms along with fatigue, pos ANA and double stranded dna? And not the classic symptoms?

Is it possible that a person have lupus and CNS symptoms along with fatigue, pos ANA and double stranded dna? And not the classic symptoms?

Yes: You need to see a rheumatologist to confirm you have lupus. The answer to your question is yes but it is not clear whether you have lupus of not. ...Read more

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I had a positive ana, double stranded dna, and I believe smith's antibodies. I also had a butterfly rash at the time. Besides lupus, what could it be?

I had a positive ana, double stranded dna, and I believe smith's antibodies. I also had a butterfly rash at the time. Besides lupus, what could it be?

Probably Lupus: A butterfly rash is often seen with lupus, but could also been seen with vitamin deficiency disorders like pellagra or connective tissue disases like dermatomyositis. However, the positive ANA and smith's antibodies most likely indicate it is lupus. You should see your physician to be properly diagnosed. ...Read more

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How common is it to get a false positive for lupus while pregnant. I also have hashimotos got a + double stranded DNA very high?

It certainly: Can occur and is also associated weakly with your prior diagnosis of hashimoto's check w/ your doctor for more info. ...Read more

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What can a double stranded DNA blood test indicate?

What can a double stranded DNA blood test indicate?

Lupus.: Systemic lupus erythematosus can be associated with dsdna antibodies, although these can be seen with other autoimmune disorder of overlap. ...Read more

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My double stranded DNA is 6 which is "indeterminate" what does "indeterminate" mean when it comes to this test?

My double stranded DNA is 6 which is "indeterminate" what does "indeterminate" mean when it comes to this test?

DNA: There is no such thing dna 6. Are you taking about human herpes virus 6 dna detection test. If so, indeterminate means antibody titer is neither positive nor negative. It is falling in the grey zone. ...Read more

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What does it mean if your double stranded DNA test comes back positive?

Hard to say: The results need to be evaluated in the context of the clinical picture. What symptoms led to the test being ordered in the first place? ...Read more

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Hi there, I have sjögrens syndrome and mild lupus but my double strand DNA was neg, my ANA was 1:640 with speckled pattern. How can it be mild lupus?

Questionable: No one knows what lupus really is, so it's defined in terms of a checklist. A certain total number of findings allows the diagnosis to be made. The real question is, "do we treat, and if so, how? " good luck -- sjogren's alone is quite a challenge, and often runs with lupus or lupus-like illness and gives its own positive ana. ...Read more

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ANA1:320 DNA neg CCP neg RF neg. My rheumatologist believes I have RA but testing for lupus due to symptoms but all these blood tests are confusing.?

ANA positive: A lot depends upon what is going on. With a person's signs and symptoms and the suspected disorder, ANA testing may be used along with or followed by other autoantibody tests. Lupus is only one thing that may be ANA positive. Others are sjogrens and other autoimmune. Many symptoms overlap/positive ana further testing may be ordered. Speak to your DR Its what rheumatologists know a lot about! ...Read more

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Do I have lupus? Ana screen came back as positive/abnormal. Ana titers are 1:320. Dna test came back as normal. My mchc is low and so are my iron stor

Connective tissue dz: This finding show that you have some kind of connective tissue disease and could be lupus. But you should discuss with your pcp and make further plan for treatment. ...Read more

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SM 5 RNP 9 SSA 14 SSB 7 SCL-70 10 JO-1 7 Histone 3 Centromere 3 CCP 1 ANA 1:320 DNA neg. Do these blood tests indicate lupus?

+ ANA: This may indicate Lupus, you need to f/u with your Rheumatologist to get a complete explanation of all of your results. It looks like you definitely have some kind of autoimmune disorder. Are you having any kind of pain in your joints? What is your RA factor? Let your Dr. Know about this. Good Luck ...Read more

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Hi, I'm worried about Lupus. Waiting to see specialist. Double Strand DNA is 5, noted as indeterminate. ANA is 1:640. And eGFR is 85. Joint pain.

Hi, I'm worried about Lupus. Waiting to see specialist. Double Strand DNA is 5, noted as indeterminate. ANA is 1:640. And eGFR is 85. Joint pain.

Lupus is possible.: The specialist will be able to help you to see if your symptoms, in combination with that blood test results, would be consistent with lupus. Lupus is a rather nebulous diagnosis, with many nonspecific symptoms in combination. Joint pain alone does not give us that diagnosis, and blood testing is not considered diagnostic but more circumstantial. ...Read more

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The only pos blood test I have is ANA of 1:320. Neg RF CCP DNA and SM antibody was low of 10. Extreme joint pain 6 mnth. RA, lupus, or neither?!

+ ANA: There are other spondyloarthropathy that can cause a lot of pain and will require treatment. Did they do an HBLA27 test? Make sure you f/u with your rheumatologist. If you have RA you can get these results. You may need to start a biologic medication. Good luck and feel better soon) ...Read more

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Joint pain, moves around, stiff after sleeping or sitting, but once moving gets better. Weak. Fatigue. +ANA Homogeneous 1:160 ds DNA negative. Lupus? What test next?

Joint pain, moves around, stiff after sleeping or sitting, but once moving gets better. Weak. Fatigue. +ANA Homogeneous 1:160 ds DNA negative. Lupus? What test next?

Incomplete history: Lupus requires meeting at least 4 criteria. Your information suggesting meeting the immunological criteria and at least one symptom criteria. Definitely need follow up with your Rheumatologist. Any skin lesions or abnormal renal or blood count results? Good luck ...Read more

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Positive ana, anti double stranded DNA of 6 and sjogrens ant ss b of 2.7? Normal?

Depends: Depends on normal range for those tests and positive ANA is meaningless without knowing the titer. ...Read more

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Would bloods for autoimmune screen ANA double stranded DNA ENA anca still show positive if there had been an autoimmune response even 6 years ago?

Would bloods for autoimmune screen ANA double stranded DNA ENA anca still show positive if there had been an autoimmune response even 6 years ago?

See below: You also have to take in account that these panels frequently have false positives and assays vary from lab to lab. It is has been estimated that up 30% of all anas drawn are false positives. Only your doctor or your rheumatologist can interpret these results in context with your history and symptoms. ...Read more

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Dna marker came back not confirming lupus but not saying I had it? What did my dr mean by this.

Dna marker came back not confirming lupus but not saying I had it? What did my dr mean by this.

Negative lab test: SLE is diagnosed by a list of clinical and lab criteria. The anti double stranded DNA is only one if the tests used. A negative test does not mean you don't have SLE. A positive test died not mean you have SLE. From what you wrote I am guessing your test was negative. A rheumatologist can help you track this down and tell you if you do or don't have SLE. ...Read more

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Does ANA 1:320 with symptoms indicate lupus even if the DNA was neg and SM was low? RF neg and CCP neg.

Diagnosis: Of lupus is based on meeting the criteria for diagnosis. Positive ANA is part of the criteria, is sensitive but not specific. Double stranded DNA is specific. Follow up with your Rheumatologist or Internist ...Read more

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Do you need to be positive for BOTH ANA and ANTI DNA to be diagnosed with lupus? What is the criteria?

No: You can still have lupus if one, both or neither are positive. There are eleven diagnostic criteria. Goigle the topic and read it for yourself. ...Read more

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Can you be diagnosed with lupus if you have only positive ANA and symptoms? Even if DNA was negative.?

Can you be diagnosed with lupus if you have only positive ANA and symptoms? Even if DNA was negative.?

Yes: You may have lupus in the absence of a positive anti DNA antibody test. Among other possibilities you may suffer from seronegative lupus. In time the test may become positive. ...Read more

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Dr said ihave lupus. What does all of this mean my ANA direct was + my anti DNA 48 what does all this mean?

See details: Lupus is an autoimmune disease with many possible clinical manifestations I see you are already on Plaquenil (hydroxychloroquine) and Methotrexate which is often a very effective combination. The best thing you can do is by under the care of a rheumatologist and stay on your meds. It is always better to be preemptive with this disease. ...Read more

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How does anti DNA antibody come from lupus?

Anti-DNA antibody: People with lupus develop abnormal substances in their blood called antibodies. These antibodies attack various organs of the body and cause the signs and symptoms of the disease. Anti-dna antibody is one such substance. The exact reason why people develop these antibodies is not known but there is often a genetic component (family history). ...Read more

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Neg ana. Anti ds DNA indeterminate (value 6) 0-4 neg, 5-9 indeterminate, 10+ pos. All other labs normal. Possible lupus? No real other symptoms.

Neg ana. Anti ds DNA indeterminate (value 6) 0-4 neg, 5-9 indeterminate, 10+ pos. All other labs normal. Possible lupus? No real other symptoms.

Lupus not likely: Unless ANA is a false negative, it's unlikely to be lupus. Lupus is a clinical diagnosis, but without a positive ANA it's very unlikely. Diagnosis can only be made by a rheumatologist. ...Read more

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With a family history of lupus and 7 out of 11 symtoms, can you still have lupus if after 2 positive ANA and anti DNA you have a negitive result?

Yes: I agree with dr. Namey on this issue. I would not disregard the previously positive tests even if the current studies are negative. Have you seen a rheumatologist? ...Read more

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My rheumatologist confirmed that I am + anti DNA antibodies but he will not confirm it as lupus, what else could it be?

Many things: 1. Positive antibodies can proceed the onset of disease. 2. It could be a false positive. 3. Low titers, especially if IgA can be seen in healthy populations. Accuracy also depends on the type of test that was used whether it was ELISA or ria. No test in medicine is 100% and rheumatology tests are worse than most. ...Read more

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I had a positive ANA of 1:40 Nucleolar pattern and an anti DS DNA come back high at 6 along with multiple Lupus symptoms. Does this mean I have Lupu?

May be: A number of criteria need to be met to diagnose lupus.
You may consult this site that lists the various criteria and the number needed for the diagnosis.
http://www. Lupus. Org/answers/entry/lupus-diagnostic-criteria
Wish you good health! ...Read more

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Anti ds DNA ranging 24-34, low platelets 133k, low c3, normal C4 but no physical symptoms. Dr says not lupus, but what would cause it?

Too early: Your labs suggest a connective tissue disease that has not yet manifested itself. At this point the best thing would be regular follow ups with your pcp and a rheumatologist. ...Read more

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My mother is 45 y/o, she been diagnosed with lupus in the joints. Dna is (-) but her ANA is high. Doc want to give penlesta inj. Should I let her take t?

My mother is 45 y/o, she been diagnosed with lupus in the joints. Dna is (-) but her ANA is high. Doc want to give penlesta inj. Should I let her take t?

Probably: This question is impossible to answer without knowing the severity of the disease and her previous therapies. That said, Benlysta (belimumab) is a very effective therapy for many people with lupus. ...Read more

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Ana 320, borderline anti ds DNA, joint pain upon pressure in the palms of the hands for three weeks. My dr said it is not lupus, can he be mistaken?

Possibly, but unlike: Possibly, but unlikely. Joint pain on pressure is an unusual symptom. Rheumatologic evaluation my clarify. ...Read more