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Doctor insights on: Dornase Alfa

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Dr. Katharine Cox
4 Doctors shared insights

Dornase Alfa (Overview)

Dornase alfa is a lung agent.


Dr. C. michael Bowman Dr. Bowman
Pediatrics
42 years in practice
University of Wisconsin School of Medicine and Public Health
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How is dornase alfa helpful?

How is dornase alfa helpful?

Thinning mucus: Dornase alfa, called "pulmozyme", breaks down dna which is part of the material in thck chest mucus in patients with chronic lung disease such as cystic fibrosis. The medicine thins the mucus and makes it easier to cough out. It is used every day for months or years and gets into the lungs by inhaling the medicine in a mist. Treatments take 10-20 minutes. It's not used for colds or bronchitis.

Dr. Katharine Cox
4 Doctors shared insights

Dornase Alfa (Overview)

Dornase alfa is a lung agent.


Dr. C. michael Bowman Dr. Bowman
Pediatrics
42 years in practice
University of Wisconsin School of Medicine and Public Health
2

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Do you have idea about dornase alfa uses?

Thick chest mucus: Dornase alfa, called pulmozyme, (dornase alfa) is a medicine that makes lung mucus thinner and easier to cough up. It was developed for patients with cystic fibrosis and is used every day for months or years. It is not used for short-term colds or bronchitis. It gets into the lungs by breathing in a mist of the medicine from a nebulizer machine. Treatments usually take 10-20 minutes.

Dr. C. michael Bowman Dr. Bowman
Pediatrics
42 years in practice
University of Wisconsin School of Medicine and Public Health
3

3
How is dornase alfa helpful?

Thinning mucus: Dornase alfa, called "pulmozyme", breaks down dna which is part of the material in thck chest mucus in patients with chronic lung disease such as cystic fibrosis. The medicine thins the mucus and makes it easier to cough out. It is used every day for months or years and gets into the lungs by inhaling the medicine in a mist. Treatments take 10-20 minutes. It's not used for colds or bronchitis.

Dr. C. michael Bowman Dr. Bowman
Pediatrics
42 years in practice
University of Wisconsin School of Medicine and Public Health
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Where should dornase alfa be stored?

Where should dornase alfa be stored?

In the refrigerator: There should be specific instructions when you get a new prescription as to where to store it (what temperature and for how long), and whether light damages it. There should also be an expiration date to tell you when it will no longer work if you keep it too long. Don't use it afterthat date. If you have questions, ask your pharmacist or go to the web site shown in the package insert.

Dr. C. michael Bowman Dr. Bowman
Pediatrics
42 years in practice
University of Wisconsin School of Medicine and Public Health
5

5
Do you have idea about dornase alfa uses?

Thick chest mucus: Dornase alfa, called pulmozyme, (dornase alfa) is a medicine that makes lung mucus thinner and easier to cough up. It was developed for patients with cystic fibrosis and is used every day for months or years. It is not used for short-term colds or bronchitis. It gets into the lungs by breathing in a mist of the medicine from a nebulizer machine. Treatments usually take 10-20 minutes.

Dr. Amrita Dosanjh Dr. Dosanjh
Pediatrics - Pulmonology
32 years in practice
UC San Diego School of Medicine
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My sister makes herself throw up when she does her pulmozyme (dornase alfa). What can I do to help her?

My sister makes herself throw up when she does her pulmozyme (dornase alfa). What can I do to help her?

Mgt/CF: Some secretions can be swallowed and this can cause irritation of the stomach lining. She should speak with her PCP about the use of an antacid, following the Pulmozyme (dornase alfa) with nebulized saline to clear the secretions. Chest physiotherapy is an important part of her management. Does she wear a vest for CPT? A virtual consultation to review chest clearance and her medications can be booked online.

Dr. Aaron Milstone Dr. Milstone
Internal Medicine - Pulmonology
23 years in practice
Wayne State University School of Medicine
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Could pulmozyme (dornase alfa) use result in increased respiratory rate in non-cf patient with a tracheostomy?

Could pulmozyme (dornase alfa) use result in increased respiratory rate in non-cf patient with a tracheostomy?

Maybe: Side effects with Pulmozyme (dornase alfa) are various and can include irritation of the throat, nose and voice changes. It can also cause hoarseness. I use a fair amount in my patients and have not seen it increase respiratory rate. I guess if it was irritating the airway you could breath faster due to pain/discomfort. I don't think that increased resp rate is very common on this drug.

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Dr. Patrick Weix Dr. Weix
Obstetrics & Gynecology
years in practice
University of Texas Southwestern Medical School at Dallas
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Is it safe to take pulmozyme (dornase alfa) while pregnant or breastfeeding?

Is it safe to take pulmozyme (dornase alfa) while pregnant or breastfeeding?

Yes: Pulmozyme (dornase alfa) is a category b, deemed safe in pregnancy. Its safety in lactation is unreported, but should have minimal absorption, and I would consider the benefits vs risk for lactation on a case-by-case basis with my patients.

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Dr. Anthony LaBarbera Dr. LaBarbera
Pediatrics
24 years in practice
University of Pittsburgh School of Medicine
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I have a patient on Pulmicort and dornase, which one should I give first and why?

I have a patient on Pulmicort and dornase, which one should I give first and why?

See Below: I'm confused. If this is a patient, you need to discussing this with the patient's doctor.

Dr. Paul Turek Dr. Turek
Urology
30 years in practice
Stanford University School of Medicine
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Is it okay to masturbate while taking alfa blockers?

Sure: You make have backwards or retrograde ejaculation and notice a dry ejaculate when ejaculating on alpha-blockers. It is not harmful...You simply urinate the sperm from the bladder the next time you pee. Makes fertility a little hard sometimes. See: http://theturekclinic. Com/services/male-sexual-health/ejaculatory-disorders/.

Dr. Steven Ginsberg Dr. Ginsberg
Internal Medicine - Hematology & Oncology
33 years in practice
State University of New York Downstate Medical Center College of Medicine
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What're normal doses of procrit (epoetin alfa)?

What're normal doses of procrit (epoetin alfa)?

See below: Erythropoetin doses vary widely, depending on the patient's weight, and reason for treatment. As little as 50-100 units per kilogram of a person's weight, or up to 60, 000 units may be used with each injection.

Dr. Kelty Baker Dr. Baker
Internal Medicine - Hematology
24 years in practice
Baylor College of Medicine
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Do you need a script for epogen (epoetin alfa)?

Erythropoietin: Epogen (epoetin alfa) is a very expensive medication which can only be prescribed by a physician (usually a hematologist, oncologist, or nephrologist). Some insurance plans won't let the patient give it to themselves and instead insist that it be given in the doctor's clinic.

Dr. Videh Mahajan Dr. Mahajan
Internal Medicine
21 years in practice
Baba Farid University of Health Sciences Guru Govind Singh Medical College
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What would happen if I missed a dose of peginterferon alfa-2b?

What would happen if I missed a dose of peginterferon alfa-2b?

Interferon: It is typically used for treatment hepatitis c. Replapse may occur with missing a dose.

Dr. Robert Rahimi Dr. Rahimi
Internal Medicine - Hepatology
5 years in practice
University of Virginia School of Medicine
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Any long term side effects from pegasys (peginterferon alfa 2a)?

Usually not: In general, once you have finished your treatment with pegasys, (peginterferon alfa 2a) side effects/symptoms that you were having during treatment slowly disappear, but can take up to 6 months and in some instances 1 year although rare. It can result in autoimmune disorders, although this is also rare. I would discuss your concerns with your treating physician for other rare long term side effects.

Dr. Charles Turck Dr. Turck
Pharmacology
13 years in practice
Midwestern University Chicago College of Osteopathic Medicine
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What side effects are associated with interferon alfa-2b injections?

What side effects are associated with interferon alfa-2b injections?

Many; see below: Many of patients experience flu-like symptoms like fever, chills, headache, fatigue, and weakness within 1-2 hours of taking the medication. Symptoms like irregular heartbeat, chest pressure or tightness, hallucinations, irritability, insomnia, depressive mood, and suicidal thoughts may also occur. It’s important to report any of these to your doctor.

Dr. Lori Wagner Dr. Wagner
Internal Medicine
23 years in practice
Medical College of Georgia School of Medicine
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What are some common side effects of pegasys (peginterferon alfa 2a)?

What are some common side effects of pegasys (peginterferon alfa 2a)?

Flu-like symptoms: Although Pegasys (peginterferon alfa 2a) has been known to make psychiatric symptoms worse and cause some problems with bone marrow suppression (anemia, low white count, low platelets), the most common side effect is flu-like symptoms.

Dr. Swati Avashia Dr. Avashia
Internal Medicine & Pediatrics
19 years in practice
West Virginia University School of Medicine
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What are the drugs those can interact with pegasys (peginterferon alfa 2a)?

What are the drugs those can interact with pegasys (peginterferon alfa 2a)?

Many: There is a long list of drugs that may interact. The main ones are azathioprine, methadone, stavudine, telbivudine and theophylline. You should take to your doctor to make sure that your curent medicines do not interact with pegasys (peginterferon alfa 2a).

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Dr. Michael Dugan Dr. Dugan
Internal Medicine - Hematology
years in practice
Indiana University School of Medicine
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I take procrit (epoetin alfa) about every two weeks, is there an alternative?

Yes: Longer acting forms of erythropoietic agents have been produced. One is known as aranesp, (darbepoetin alfa) and is dosed every 3-4 weeks.

Dr. Jeffrey Crespin Dr. Crespin
Internal Medicine - Gastroenterology
24 years in practice
Washington University School of Medicine
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Can you tell me the difference between peginterferon alfa 2a & peginterferon alfa 2b?

Can you tell me the difference between peginterferon alfa 2a & peginterferon alfa 2b?

Drug names: Both are pegylated interferons. Peginterferon alfa 2a is made by roche branded Pegasys (peginterferon alfa 2a) and is a slightly larger molecule. Peginterferon 2B is made by schering and its dose is calculated based on body weight. The brand name is peg-intron. These drugs have similar efficacy and side effects.

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Dr. Jason Hemming Dr. Hemming
Internal Medicine - Gastroenterology
13 years in practice
Tufts University School of Medicine
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What is the usual procedure for preparing and injecting pegasys (peginterferon alfa 2a)?

What is the usual procedure for preparing and injecting pegasys (peginterferon alfa 2a)?

Simple Steps: Simple steps but all need to be done and it is best to have formal treating by a health care provider before starting. Basically it involves preparing the syringe and then drawing up the medication. Next you will need to find a spot on your abdomen or thigh and then inject into a pinched segment of skin.

Pulmozyme (Definition)

Pulmozyme ...Read more