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Doctor insights on: Dopamine Restless Legs

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Do Dopamine agonists for Restless Leg Syndrome cross the Blood Brain Barrier? If not, why are side effects like psychosis possible?

Do Dopamine agonists for Restless Leg Syndrome cross the Blood Brain Barrier? If not, why are side effects like psychosis possible?

Clarification: Of course, dopamine agonists cross the brain-blood barrier and interact with appropriate receptors. I suggest you sit down face to face with your doctor and discuss all of your misgivings. ...Read more

Akathisia (Definition)

The best way to consider akathisia is to imagine the need to move. Patients with this condition have major problems sitting still. They have a need to move. This can be a side effect of medication, may be associated with disease such as parkinsons, or may be a normal variant. Most doctors use it it describe the ...Read more


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I read that low dopamine is a cause of restless legs--how does this happen?

I read that low dopamine is a cause of restless legs--how does this happen?

Restless legs: Studies have shown that more than 60% cases of RLS are inherited as an autosomal dominant inheritance, & that there is deficiency of Dopamine in the part of the brain known as substantia nigra. ...Read more

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Hi, I have really bad restless leg syndrome and I have problems with food, I binge. Would this be anything to do with low dopamine levels?

Hi, I have really bad restless leg syndrome and I have problems with food, I binge. Would this be anything to do with low dopamine levels?

Hard to say: There really isn't a test to determine if a person has abnormal Dopamine levels in the brain. The antidepressant medication buproprion can elevate Dopamine levels. You should see a psychiatrist and have an evaluation. Good luck. ...Read more

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If someone has depression & restless leg syndrome due to renal failure, what type of antidepressant is best. Dopamine agonist, ssri, benzo, or combo.

If someone has depression & restless leg syndrome due to renal failure, what type of antidepressant is best. Dopamine agonist, ssri, benzo, or combo.

Many choices: You need to talk to your physician because there are many other issues we cannot cover. Since you have both depression renal failure and restless legs each needs specific diagnostic evaluation help answer your question. ...Read more

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What is restless leg syndrome?

What is restless leg syndrome?

What is RLS?: Restless Leg is a condition where you have an uncomfortable sensation (burning, crawling, cramping, aching, tingling, etc.) in you legs that cause an urgent/irresistible need to move your legs (walking, moving legs, messaging, rubbing, etc.). This movement usually occurs when going to bed and can progress to the daytime and sometimes to the arms. See a movement disorder neurologist for Treatment. ...Read more

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What eases restless leg syndrome?

What eases restless leg syndrome?

Multiple: Dopamine agonists work best and include ropinorole, pramipexole, the new Neupro (rotigotine) patch. More traditional meds have included l-dopa, and clonazepam. If you have anemia or kidney disease, better treatment of these conditions may work. Check serum ferritin as some folks may have issues with iron metabolism. Rls is occasionally associated with ms>. ...Read more

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What causes restless leg syndrome?

What causes restless leg syndrome?

See below: Maybe genetic, but more often is sporadic without family history. May be related to problems with iron metabolism. ...Read more

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What causes restless leg syndrome?

What causes restless leg syndrome?

NOT FULLY KNOWN: But do find some patients with disruption of iron stores, so, can check ferritin levels. We do find some problem with dopamine issues, and find success in using dopamine agonists, but another approach using Horizant, affects different brain chemicals. May be some genetic links in a few families, and association with a sleep disorder in some also found. ...Read more

Dr. Michelle Zetoony
366 doctors shared insights

Restless Leg Syndrome (Definition)

Urge to move: irresistible, involves legs but may involve arms and trunk worse at rest relieved with movement (no symptoms during movement) but may recur once a person stops moving/walking worse in the ...Read more


Dr. Alan Wartenberg
231 doctors shared insights

Restless Legs Syndrome (Definition)

Restless leg syndrome is a disorder in which there is an urge or need to move the legs ...Read more