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Doctor insights on: Dopamine Hypothesis

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Do only dopaminergic neurons release dopamine?

Do only dopaminergic neurons release dopamine?

Yes: Yes, only dopaminergic neurons release dopamine, but there are several dopaminergic pathways in the brain. Dopaminergic neurons in midbrain are the main source of Dopamine in the mammalian cns. Losing these is associated with parkinson's disease. Dopamine neurons are involved with voluntary movement and other behavioral processes such as mood, reward, addiction, psychosis, and stress. ...Read more

Dr. Martin Johnson
918 doctors shared insights

Dopamine (Definition)

Dopamine is an inotrope which is a kind of heart ...Read more


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What's feingold hypothesis?

What's feingold hypothesis?

Unproven ADHD / diet: The 1988 pop claim that food additives or whatever in the diet causes / exacerbates attention-deficit disorder. Since parents both administer the feingold diet and judge its effect, there may be natural to see faces in the clouds or a desired effect; why the many substances all happen to be synthetic doesn't fit with other food hypersensitivities, but some folks claim good results. ...Read more

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Do norepinephrine reuptake inhibitors suppress growth of brain?

Do norepinephrine reuptake inhibitors suppress growth of brain?

No: At this time, there is no evidence to suggest this. As one may imagine, few if any studies have been performed in humans to look for this. ...Read more

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Do antipsychotics affect motivation because it blocks dopamine receptors?

Do antipsychotics affect motivation because it blocks dopamine receptors?

Meds and motivation: Antipsychotic meds used primarily for serious psychiatric disorders can help motivation as they improve disordered thinking, delusions and hallucinations. People who no longer have psychotic symptoms tend to function better and are more motivated overall. I hope this helps. ...Read more

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Does exercise increase serotonin by stimulating the uptake of tryptophan by brain synaptosomes(sze py.1976)?

Does exercise increase serotonin by stimulating the uptake of tryptophan by brain synaptosomes(sze py.1976)?

Stress does: That paper describes increased uptake of tryptophan caused by glucocorticoids. If you stress yourself while exercising, you might get some increase in the uptake, however, direct connection between tryptophan uptake and exercise was not described. ...Read more

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Does coffee affects the levels of serotonin, noradrenaline and dopamine ?

Does coffee affects the levels of serotonin,  noradrenaline and dopamine ?

Yes: The caffeine in coffee blocks Adenosine receptors, which when activated make you tired and sleepy. This blockade also affects all major neurotransmitters, such as dopamine, acetylcholine, serotonin -- and in high doses, norepinephrine too. Dopamine effects are not in the exact same regions of the brain that other addictive substances affect, though. ...Read more

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A lack of GABA and dopamine in asperger's syndrome? What role does serotonin play in asperger's?

A lack of GABA and dopamine in asperger's syndrome? What role does serotonin play in asperger's?

Aspergers: Research is suggesting spectrum kids may be awash in serotonin in utero. There is speculation that ssri's may not be the best route in treating some of the difficulties associated with the spectrum because there may already be too much serotonin. Hopefully, future research will clarify. This is my take on the spectrum. http://www.youtube.com/watch?v=xg1ngp1ngds. ...Read more

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Since there's deep brain stimulation that stimulate neurons, is there deep brain "inhibition" that inhibits neurons?

Since there's deep brain stimulation that stimulate neurons, is there deep brain "inhibition" that inhibits neurons?

Yes: It is interesting that it is called " stimulation", in fact it inhibits the neuron depending upon the degree of stimulation applied. For example the involuntary movement of Parkinson's disease are controlled by "inhibition". Similarly " interstim" is the technique to stimulate to cause inhibition of bladder contractions to cure loss of urinaty control. The entire process is well understood. ...Read more

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What foods or supplements increase serotonin, norepinephrine, and dopamine?

What foods or supplements increase serotonin, norepinephrine, and dopamine?

St Johns wort: Is a very potent herb and should not be used with other anti-depressants. ...Read more

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Will rhodiola rosea herb decrease norepinephrine levels in brain?

Will rhodiola rosea herb decrease norepinephrine levels in brain?

Probably not: There are anecdotal reports that this native siberian plant increases brain norepinephrine, but, to my reading, this may be open to question. ...Read more

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What are GABA antagonists that lead to gaba-a receptor up-regulation?

What are GABA antagonists that lead to gaba-a receptor up-regulation?

Not safe: GABA antagonists are not routinely prescribed for GABA A receptor upregulation. The main one flumazenil (clonazepam) is used for overdoses from benzodiazepines in an ER setting. It may cause withdrawal seizures. Your best bet is to detox and enter a drug tx program for alcohol or sedative-hypnotic dependence issues. ...Read more

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Are all antipsychotics dopamine antagonist?

Are all antipsychotics  dopamine antagonist?

Yes: Although atypicals are more selective about the Dopamine receptors they block and also act on seratonin receptors. ...Read more

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Is Depakote a dopamine antagonist?

Is Depakote a dopamine antagonist?

No: According to our current understanding, Depakote work by altering calcium current, sodium channel, and the synthesis and breakdown of gaba, the main inhibitory neurotransmitter in the brain. ...Read more

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Does dopamite(dopamine supplement) increase more dopamine level or prescribed medicine like biperiden(dopamine reuptake inhibitor) does?

Does dopamite(dopamine supplement) increase more dopamine level or prescribed medicine like biperiden(dopamine reuptake inhibitor) does?

I'm curious: Why do you believe you need to take medication that claims to affect dopamine, especially OTC remedy which will NOT cross the brain-blood barrier? If you are depressed, you could see a psychiatrist, and if you have Parkinson's disease, a neurologist. ...Read more

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Does dopamine increase OCD symptoms?

Does dopamine increase OCD symptoms?

Dopamine, OCD Sympto: I feel your distress about OCD symptoms. A 2004 study in the "American Journal of Psychiatry" indicates a positive correlation between increased dopamine activity and people with OCD. The University of Utah notes that OCD is linked to increased levels of dopamine There is no conclusive research that dopamine increases OCD symptoms. See Psychiatrist for Diagnosis and treatment. ...Read more