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Doctor insights on: Does Zoloft Make You Tired

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Does Zoloft (sertraline) make you tired?

Does Zoloft (sertraline) make you tired?

Yes,it can: This will usually, but not always, go away with time. Please discuss your options with your treating physician. Best wishes. ...Read more

Dr. Heidi Fowler
1,087 doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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I have been on Zoloft (sertraline) for 4 months. I have been on 200mg for 8 weeks. Only now am I experiencing super tiredness, dizzy,nausea, no appetite. This normal?

I have been on Zoloft (sertraline) for 4 months. I have been on 200mg for 8 weeks. Only now am I experiencing super tiredness, dizzy,nausea, no appetite. This normal?

Side effects: These are definitely in the realm of side effects. Did these side effects occur suddenly or slowly over time. Slowly over time would make more sense as the Zoloft (sertraline) begins to take effect. This medication may not be the right one for you if it starts to cause difficulties in other aspects of your life (with respect to side effects). If nothing else has changed or is causing this of course. ...Read more

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On day 6 of Zoloft (sertraline) and feel tired and kind of sick. I usually exercise a lot but have not been this week. Could it help if I start back exercising?

On day 6 of Zoloft (sertraline) and feel tired and kind of sick. I usually exercise a lot but have not been this week. Could it help if I start back exercising?

Zoloft (sertraline): Zoloft (sertraline) can cause side effects of tiredness and nausea, at least temporarily. Hopefully they will pass within a couple of weeks. If exercising in general helps you feel better, it may work this way at this time as well. ...Read more

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No sleep for days on Zoloft (sertraline) and not tired, I have to force myself to sleep?

No sleep for days on Zoloft (sertraline) and not tired, I have to force myself to sleep?

Don't know your: Diagnoses? Insomnia can occur with zoloft (sertraline) but you shouldn't have NO sleep. Do you have bipolar spectrum disorder? Please let you physician / psychiatrist know asap if you have stopped sleeping. ...Read more

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I just started taking Zoloft (sertraline) and everytime i. Feel tired why do Zoloft (sertraline) make you lethargic?

I just started taking Zoloft (sertraline) and everytime i. Feel tired why do Zoloft (sertraline) make you lethargic?

Side effect : Zoloft (sertraline) is an antidepressant that can cause side effects, including tiredness. In some instances, these side effects are temporary, where the side effect goes away with time. In other instances, it can be a side effect that lasts as long as you continue the medication. Best to discuss these with the prescribing physician. ...Read more

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I've been taking 100mg Zoloft (sertraline) for about 1 and 1/2 year but I feel tired, sluggish, an have little motivation. I want to stop taking it or try a diff ad?

I've been taking 100mg Zoloft (sertraline) for about 1 and 1/2 year but I feel tired, sluggish, an have little motivation. I want to stop taking it or try a diff ad?

Discuss with your Dr: You have some good points as you are on a relatively good dose of the sertraline, yet have the symptoms as described. For continuity of care and to assure the treating physician, who knows your case best, it is important for you to discuss these important issues and concerns with them. Best wishes. ...Read more

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Are Zoloft (sertraline) fatigue symtoms temporary?

Are Zoloft (sertraline) fatigue symtoms temporary?

FATIGUE EVAL: Normally will resolve as Zoloft (sertraline) doseAdjustment. If not you need full EXAM AND labs. CBC/CMP/B12/FOLATE /TFTS/VITD/CRP//SED RATE//IRON STUDIES/LYME TITERS. Start a. Gluten free diet Wholeapproach.com gutbliss.com. And high potency vitamins. Rejuvenation-science.com Then review results if no firm diagnosis is made, a sleep study may be necessary much subtle sleep disorders cause Fatigue ...Read more

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30yearold woman&have been tired for as long as I can remeber. At least since teens. What could this be? On bc&zoloft currently. B4 that other similar meds

30yearold woman&have been tired for as long as I can remeber. At least since teens. What could this be? On bc&zoloft currently. B4 that other similar meds

Get a full check up: Tiredness could be a symptom of many diseases including physical, emotional and hormonal to name a few. Get a full medical checkup to see if any underlying factors other than depression could be contributing to your symptoms. ...Read more

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I am constantly tired on zoloft (sertraline). I currently take it in the morning, is it possible if I switch to take it at night this will help with fatigue?

I am constantly tired on zoloft (sertraline). I currently take it in the morning, is it possible if I switch to take it at night this will help with fatigue?

It could: If zoloft (sertraline) makes you sleepy or fatigued, taking it at night may decrease this effect. Tiredness and fatigue can also be symptoms of depression, though. Not knowing how you were before beginning the medication, it's hard to know which is happening (ongoing depression or side effects from zoloft (sertraline)). Best to speak with your physician so s/he can advise you better. ...Read more

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I have been on zoloft for 3 years now. My doc changed me to serdep. I just really feel fuzzy and tired, it's been a week now, is this normal? Should i just wait it out? Appreciate the advice

I have been on zoloft for 3 years now. My doc changed me to serdep. I just really feel fuzzy and tired, it's been a week now, is this normal? Should i just wait it out? Appreciate the advice

Generic: Serdep is a generic of Zoloft. Essentially the same medication. If it does not agree with you ask your doc to have it changed. There are many other options. ...Read more

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Does Zoloft (sertraline) and buspirone cause fatigue?

Does Zoloft (sertraline) and buspirone cause fatigue?

No: In my practice, with my patients, I have not seen a patient with fatigue caused by either zoloft (sertraline) or buspirone, either along or together.
If you are taking them for depression and anxiety, fatigue may be caused from either underlying condition.
Please consult with your treating physician. ...Read more

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Took Zoloft (sertraline) 100mg 2 months, stopedcold. Only dizzy & very tired, how long will this last?

Stopping Zoloft (sertraline): If stopping zoloft, (sertraline) tapering is advised so that you have less of the kind of symptoms you're experiencing. Doing things the way you have, your symptoms can last for several weeks or even a couple of months. ...Read more

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My boyfriend won't take meds now cuz zoloft (sertraline) made him so tired. Now he gets paranoid and jealous. Is there hope cuz I love him so much...

My boyfriend won't take meds now cuz zoloft (sertraline) made him so tired. Now he gets paranoid and jealous. Is there hope cuz I love him so much...

Other medications,: That do not cause tiredness, are available that may be helpful for your boyfriend. If he was not paranoid or jealous while he was taking the Zoloft (sertraline) then another medication may help to control these problems without the same side effect. I suggest some intensive counseling to try to get to the root of his paranoia and jealousy, which may or may not be treatable with medication. ...Read more

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What withdrawal can I expect tappering Zoloft (sertraline) 50 mg a week from 200 mg a day it's day 5 fill very tired like my head is empty and got bad runs.

What withdrawal can I expect tappering Zoloft (sertraline) 50 mg a week from 200 mg a day it's day 5 fill very tired like my head is empty and got bad runs.

Slower tapering.: If your symptoms appeared when you started to cut your doses down, then go back to the previous dose which did not have the side effects and taper more slowly like cutting down by 25 mg. Doses a week at time. The symptoms are what they call "discontinuation syndrome" not the same as withdrawal from narcotics.If you continue to have problems go back to your psychiatrist. ...Read more

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R pupil larger off and on x years when tired. Started Zoloft (sertraline) 1 mo ago, now 2-3 mm larger consistently. Worse in am and dim lighting. Zoloft (sertraline) cause?

R pupil larger off and on x years when tired. Started Zoloft (sertraline) 1 mo ago, now 2-3 mm larger consistently. Worse in am and dim lighting.  Zoloft (sertraline) cause?

See a doctor: You should see an eye doctor to have this evaluated if you already haven't. Zoloft (sertraline) could worsen an existing condition with the pupil size but you need to make sure that this is benign before we assume so. ...Read more

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Took Zoloft (sertraline) 100mg for 2 months side effects were bad (I'm 17) stopped 4 days ago & I'm only a bit dizzy&very tired. How long will this last?

Took Zoloft (sertraline) 100mg for 2 months side effects were bad (I'm 17) stopped 4 days ago & I'm only a bit dizzy&very tired. How long will this last?

Did you stop cold: Turkey? Did you do this without discussing it with your medical provider? Do your parents know? Normally, ssri's are tapered. ...Read more

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Taking Zoloft (sertraline) 25mg for 4 days, already feel extremely tired, numb, zombie like. Can these side effects happen in only 4 days? Thought it took weeks

Taking Zoloft (sertraline) 25mg for 4 days, already feel extremely tired, numb, zombie like. Can these side effects happen in only 4 days? Thought it took weeks

Yes.: It is possible to experience sedating or activating side effects in the first few days after taking a ssri. Usually, the effects wear off after a few days. If you continue to experience fatigue and numbness, speak with your medical provider about possibly changing to a different med. ...Read more

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I take Zoloft (sertraline) it's been.3 months, I feel so tired and my mind is always blank i sometimes find it difficult to make a conversation is Zoloft (sertraline) the reason?

I take Zoloft (sertraline) it's been.3 months, I feel so tired and my mind is always blank i sometimes find it difficult to make a conversation is Zoloft (sertraline) the reason?

Adverse reaction: Would have some potential concern that your combination of Paxil (paroxetine) and Zoloft is causing low grade Seratonin syndrome. It would behoove you to discuss this in great detail with your doctor, as changing the therapy may make a lot of sense. ...Read more

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Which medication is more known for less fatigue, Zoloft (sertraline) or celexa? (it's for gad)

Fatigue from SSRI: It depends on the person. I have had patients complain of some sedation on both, depending on the dose, and also some anxiety from both. All in all, from my experience, I would say Celexa has slight more sedative effect than zoloft (sertraline). ...Read more

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On Zoloft (sertraline) — I won't sleep for days without fatigue or drowsiness? I know I need to sleep, I didn't have this problem before Zoloft (sertraline)

On Zoloft (sertraline) — I won't sleep for days without fatigue or drowsiness? I know I need to sleep, I didn't have this problem before Zoloft (sertraline)

Very Important !: Excessive energy and lack of sleep could be side effects of Zoloft (sertraline). It can sometimes trigger hypomania that presents as these symptoms. Immediately contact your psychiatrist or whoever has prescribed this medicine. It is important. ...Read more

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Slowly decreasing off zoloft (sertraline) for anxiety. Can a withdrawal symptom be depression? Tired and very unmotivated lately.

Zoloft (sertraline) Dose: I hope that your physician is supervising your Zoloft (sertraline) dose reduction because if you have been on it for any length of time, the titration to zero needs to be medically supervised so that you do not experience serotonin syndrome. Also, was any thought given to what antidepressant will replace the Zoloft (sertraline) once you are completely off of it? It sounds like you need an alternative antidepressant. ...Read more

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I am on Zoloft wellbutrin (bupropion) and ativan. I am still always low with no motivation or drive. I barely ever have a "good day" like 3 x a year maybe. Tired?

I am on Zoloft wellbutrin (bupropion) and ativan. I am still always low with no motivation or drive. I barely ever have a "good day" like 3 x a year maybe. Tired?

Depression: The treatment for depression often requires several trials and combinations to get the best result. Cognitive or talk therapy can augment or supplement the medications. See your psychiatrist monthly to gauge the effect of medication changes and dosages among the medications. ...Read more

Dr. Heidi Fowler
1,042 doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more