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Doctor insights on: Does Zoloft Cause Restless Leg Syndrome

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I can't stop moving my legs, can Zoloft (sertraline) cause restless leg syndrome.

I can't stop moving my legs, can Zoloft (sertraline) cause restless leg syndrome.

See below: Most selective serotonin reuptake inhibitors like zoloft (sertraline) can worsen or even initiate restless legs syndrome in some people. Have it evaluated by a sleep doctor, to check for other causes such as a low ferritin level. In some people it goes away after sometime and in some the RLS continues as long as zoloft (sertraline) is there. Discuss other options with your prescribing doctor. Also, avoid caffeine. ...Read more

Dr. Heidi Fowler
1,088 Doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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Zoloft caused restless leg syndrome and pgad (persistent genital arousal). If I stop taking zoloft will rls and pgad go away?

Zoloft caused restless leg syndrome and pgad (persistent genital arousal). If I stop taking zoloft will rls and pgad go away?

Yes: In general, findings of side effects related to medications are found in trials of reducing and/or stopping the medications to determine links between medications and side effects. There are many different antidepressants to discuss with your primary care provider as alternatives, but as always, discuss with your PCP and balance the benefits (reduced depression) vs. The harms (RLS and PGAD). ...Read more

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Zoloft (sertraline) is giving me restless leg syndrome, will it continue to do so or will it stop over time.

Zoloft (sertraline) is giving me restless leg syndrome, will it continue to do so or will it stop over time.

Side effect: If this side effect has persisted for several days to two weeks unfortunately it will likely persist

when antidepressants cause side effects consideration can be given to lowering the dose, changing medication, or adding a medicine to overcome the side effect. ...Read more

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If taking Zoloft (sertraline) can exacerbate my restless leg syndrome- does the time of day I take the meds matter? Currently taking it at bedtime.

If taking Zoloft (sertraline) can exacerbate my restless leg syndrome- does the time of day I take the meds matter? Currently taking it at bedtime.

Possible: Zoloft (sertraline) usually does NOT exacerbate RLS, but if so, you might take in morning and see if that helps. Also, you might benefit from use of a dopamine agonist at bedtime to control the restless legs. ...Read more

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Is restless leg syndrome a side effect of zoloft (sertraline)?

Is restless leg syndrome a side effect of zoloft (sertraline)?

Occasionally yes: Genetics, alcohol and caffeine, changes in exercise patterns, certain meds, iron deficiency, kidney problems, nerve damage can all cause or worsen restless legs syndrome. Zoloft (sertraline) can sometimes. It looks like you're on Mellaril which can worsen RLS too. ...Read more

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What's gabapentin is all use for? And what cause restless leg syndrome

What's gabapentin is all use for? And what cause restless leg syndrome

Many uses: Gabapentin can be used for multiple conditions. It's original indication was for seizure disorder, these days it is used for chronic pain syndromes, migraine, restless legs, post herpetic neuralgia (pain after shingles). The cause of restless legs is unclear but it is mostly thought to have a genetic basis and also seems to be associated with a Dopamine brain irregularity. ...Read more

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Can being on your period cause restless leg syndrome to be worse for the time being.

Can being on your period cause restless leg syndrome to be worse for the time being.

Yes: Yes. Iron deficiency symptoms are associated with restless leg syndrome. If your periods are heavy, get your iron level checked and discuss options to help improve heavy menstration. ...Read more

Emily Lu Dr. Lu
5 doctors agreed:
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Do antidepressants cause restless leg syndrome?

Emily Lu Dr. Lu
5 doctors agreed:
Do antidepressants cause restless leg syndrome?

Sometimes: Akisthesia (an inner restlessness that can manifest very much like restless legs syndrome) has been reported as a side effect of some antidepressants like prozac, Paxil (paroxetine) and tricyclic antidepressants. However, it is more commonly seen in patients that are on antipsychotic drugs like haldol. ...Read more

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Can a statin drug cause restless leg syndrome?

Can a statin drug cause restless leg syndrome?

Muscle spasms: A statin drug would not cause the condition known as "restless leg syndrome", but some pts taking a statin drug do report uncomfortable muscle spasms, you should consult the prescribing physician. ...Read more

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I'm taking lorazepam 1mg and tizanidne 4mg and ibproprine 800mg. Is this a safe combo? And would any of these cause restless leg syndrome?

Why?: None of these are meant to be used for a long length of time. Return to your doctor for discussion and re consideration of these medications ...Read more

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Can a car accident cause restless leg syndrome?

Can a car accident cause restless leg syndrome?

No: Restless leg syndrome generally developes insidiously (without trauma).There are good medications available for RLS. See your primary care physician. Best of Luck! ...Read more

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Diagnosed with adrenal adenoma. Can this cause restless leg syndrome? Seem to be restless all over, though, like an urge to run to shake it off.

Diagnosed with adrenal adenoma. Can this cause restless leg syndrome? Seem to be restless all over, though, like an urge to run to shake it off.

Very unlikely: Unfortunately no definite cause of RLS is known. It is suspected to be genetic. Dopamine agonist drugs like premipexole are very effective. ...Read more

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Have a sudden movement in my calf muscle at times in the night mostly cause? Restless leg syndrome?

Have a sudden movement in my calf muscle at times in the night mostly cause? Restless leg syndrome?

RLS...maybe: RLS is a common, terribly bothersome, sleep disruption that has unclear causes in most cases. Nocturnal recumbency leg cramps, on the other hand actually hurt ("Charlie horse cramp"), whereas RLS gives the sensation one just MUST move the leg/legs. Rarely, electrolyte imbalance can mimic RLS. Interestingly, some anti-Parkinson's disease meds at low doses, are highly effective for RLS. ...Read more

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Causes of restless leg syndrome? K+ deficiency?

Causes of restless leg syndrome? K+ deficiency?

RLS: It is a syndrome w/ symptoms of an urge to move the legs especially near bedtime, that improves w/ movement ; is worse @ rest. It typically has uneasy sensations. Besides its relation to low peripheral Dopamine levels ; some to genes, it is unclear why it occurs. Sometimes it may be secondary to other medical issues. It's recommended that you see a sleep medicine specialist to properly evaluate it. ...Read more

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Does restless leg syndrome cause a charlie horse in calf?

Does restless leg syndrome cause a charlie horse in calf?

No: Cramping or charlie horses in the calf are generally not part of restless leg syndrome. I would recommend that you see your doctor for further workup and treatment of what could be causing the cramping especially electrolyte disturbances. ...Read more

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What is restless leg syndrome? What are some symtons of restless legs syndrome and what cause it?

What is restless leg syndrome? What are some symtons of restless legs syndrome and what cause it?

Rapid leg movements: When asleep. Most people with the disorder do not know they have it, unless their bed partner complains of being kicked all night. Some soreness and aching in leg muscles may be present, but in my experience most patients only know they have it because they experience excessive sleepiness during the day. It interferes with normal and esp rem sleep. It is sometimes caused by iron deficiency. ...Read more

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What are possible causes of restless leg syndrome?

Often not clear: Some patients have low iron levels and those that do can have symptom relief when iron is supplemented. There is a genetic component to restless legs syndrome as it often runs in families. Many patients don't have an underlying cause. ...Read more

Dr. Alan Ali Dr. Ali
2 doctors agreed:
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Has the cause for restless leg syndrome been figured out yet?

Dr. Alan Ali Dr. Ali
2 doctors agreed:
Has the cause for restless leg syndrome been figured out yet?

RLS: Cause unknown in most cases, but it is noted to occur more in chronic kidney diseases, diabetes, iron deficiency, parkinson's disease, peripheral neuropathy, pregnancy, sedatives withdrawal & some medications such as caffeine/lithium/neuroleptics. ...Read more

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How can restless leg syndrome cause hypersomnia?

How can restless leg syndrome cause hypersomnia?

RLS: Rls can cause insomnia, or it can cause frequent minor waking up spells and non restorative sleep. ...Read more

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Could restless leg syndrome cause knee problems?

Could restless leg syndrome cause knee problems?

See below: What do you mean by knee problems? Although restless legs syndrome (rls) occurs in the calves ; feet, it is not unheard of for it to extend into the knees or arms. But it has to meet criteria to be rls, such as an urge to move that is worse @ night ; feels uneasy or discomforting. It is better w/ mov't ; worse w/ rest. If you have other symptoms it maybe something else. Please see you pcp for eval. ...Read more

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Can restless leg syndrome cause symptoms in the feet too?

Can restless leg syndrome cause symptoms in the feet too?

Yes: Stretching before and after exercise is important some labs may help determine/rule out metabolic causes. Drinking a glass of tonic water each evening often resolves this problem bc the quinine in the tonic water is helpful to stop cramping. ...Read more

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Can restless leg syndrome cause weakness of specially calve muscles and can it contribute low energy levels for daily life activities? What is the Rx

Can restless leg syndrome cause weakness of specially calve muscles and can it contribute low energy levels for daily life activities? What is the Rx

Restless leg: Restless leg syndrome (RLS) can be associated with such symptoms, although the actual muscle weakness on exam (not just by symptoms) is unlikely. See your doctor if the diagnosis hasn't been confirmed. If it has, iron supplementation (ferrous sulfate) usually is rapidly effective (a few days) in relieving symptoms. Sometimes, but not always, there is also iron deficiency anemia. ...Read more

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What causes restless leg syndrome?

What causes restless leg syndrome?

See below: Maybe genetic, but more often is sporadic without family history. May be related to problems with iron metabolism. ...Read more

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What causes restless leg syndrome?

NOT FULLY KNOWN: But do find some patients with disruption of iron stores, so, can check ferritin levels. We do find some problem with dopamine issues, and find success in using dopamine agonists, but another approach using Horizant, affects different brain chemicals. May be some genetic links in a few families, and association with a sleep disorder in some also found. ...Read more

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What exactly causes restless leg syndrome?

What exactly causes restless leg syndrome?

Dopamine lack: I think restless leg syndrome is probably caused in susceptible people (tends to be familial) by a relative lack of sufficient Dopamine and is often associated with fatigue, dopamine-blocking medicines, chronic illness, and the end of gestation. Medications that increase Dopamine are frequently helpful as can be Neurontin (gabapentin) and Klonopin (clonazepam).. ...Read more

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What is the cause for restless leg syndrome? Experiencing it night and day! Also having lower back pain.

What is the cause for restless leg syndrome? Experiencing it night and day! Also having lower back pain.

Not known: No known cause for restless legs syndrome exists. Researchers suspect the condition may be due to an imbalance of the brain chemical dopamine. This chemical sends messages to control muscle movement.
Rls runs in families in at least half the people with rls, especaily early age.
Rls sometimes accompanies other conditions.
Pregnancy
peripheral neuropathy.
Iron deficiency.
Kidney failure. ...Read more

Dr. Michelle Zetoony
380 Doctors shared insights

Restless Leg Syndrome (Definition)

Restless leg syndrome is a condition where there is a need or urge to move the leg because of some perceived unpleasant sensations. Restless leg ...Read more


Dr. Heidi Fowler
1,043 Doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more