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Doctor insights on: Does Vitamin B12 Deficiency Cause Brain And Nerve Problems

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Does vitamin B12 deficiency cause brain and nerve problems?

Does vitamin B12 deficiency cause brain and nerve problems?

Yes: In the early 19th century, scientists noted weakness and numbness with B12 deficiency. Recently, B12 has been shown to upregulate neurotrophic factors (chemicals [cytokines] that help nerve cells grow) & downregulate neurotoxic factors (chemicals that break down nerve cells). In other words, B12 helps nerve cells grow and prevents their destruction by naturally occurring brain chemicals. ...Read more

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Dr. Mohammed Parvez
237 doctors shared insights

Vitamin B12 Deficiency (Definition)

B12 deficiency can be due to a lack of absorption or intake from diet. Since B12 is primarily found in animal products (e.g., dairy, egg, meat, etc.) vegetarians are more at risk. A deficiency is suspected when rbcs increase in size (e.g., high MCV and/or MCH in cbc) and can cause megaloblastic anemia. Symptoms can include fatigue and neuropathy. It is best corrected with ...Read more


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Been suffering with lhermittes for a month (mris brain&c ok). Could a 5 year addiction to nicotine gum (15x2mg daily) cause vitamin B12 deficiency?

Been suffering with lhermittes for a month (mris brain&c ok). Could a 5 year addiction to nicotine gum (15x2mg daily) cause vitamin B12 deficiency?

Unrelated. : I think you are saying you have been suffering with lhermitte's sign, and there are no findings on brain and c-spine mris to justify your symptoms. You know that b-12 deficiency can cause it, so you wonder if nicotine gum has caused that. No. Start by talking to your doc about whether you have a b-12 deficiency. Some people simply can't absorb b-12. Ssri discontinuation can also cause lhermitte's. ...Read more

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What would symptoms of brain damage be from a vitamin B12 deficiency?

What would symptoms of brain damage be from a vitamin B12 deficiency?

Why do you ask?: Numbness in the fingers and/or toes, and weakness in the legs are the symptoms usually reported in "vegetarian's myelopathy", which unfortunately is fairly common. How much damage to cognition has already happened isn't clear. In infants, permanent, severe mental disability has been produced by mothers who are b12-deficient and feeding only breast milk, neither supplementing. Please be smart. ...Read more

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Can a vitamin B12 deficiency cause permanent nerve damage?

Can a vitamin B12 deficiency cause permanent nerve damage?

If not treated: B-12 deficiency can cause peripheral neuropathy, problems with spinal cord dysfnctn (poor vibration and position sensations), and cognitive problems to the brain. Much may be reversible, but without timely treatment, problems will be persistent. 1000 mcg injections per month should suffice. ...Read more

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Can untreated vitamin B12 Deficiency cause nerve damage ? If yes,can it be seen through Nerve conduction study ?

Yes and yes: Yes solidly objective B12 deficiency (by formal laboratory test) (usually implying pernicious anemia) can cause nerve damage. Yes, it can be seen on electrodiagnostics except at very early stage. Note that in true B12 deficiency taking oral B12 does not work because the cause is a stomach abnormality that prevents B12 absorption. Solidly objective tests can confirm. ...Read more

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Can vitamin B12 deficiency cause Musculocutaneous nerve and ILiohypogastric nerve damage ?

Causes neuropathy: But unusual to have an isolated mononeuropathy over arm and abdomen. If indeed this pattern of isolated nerve involvement fits a mono neuritis multiplex, one would wonder about another responsible disorder such as diabetes or arteritis. Vit B-12 problems are typically symmetrical and distal. Might investigate all of this further with your neurologist. ...Read more

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I read that vitamin B12 deficiency can cause permanent nerve damage if left untreated for months.is it true.?

Yes: Besides for anemia maybe 12 deficiency can cause neurologic problems. This would be very unusual in somebody your age but this is something you need to discuss with your physician ...Read more

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How long does it take for vitamin b12 deficiency to cause permanent damage?Is it possible to reverse?26 years old with 5 years of cognitive problems

How long does it take for vitamin b12 deficiency to cause permanent damage?Is it possible to reverse?26 years old with 5 years of cognitive problems

Part reversible: Peripheral nerve damage is generally reversible and damage to central nervous system is usually not. Unless you have been a strict vegan, had stomach or small intestinal resection, Crohn disease for years, tape worm a few other things, it is unlikely that your disease is due to B12 deficiency. It would be prudent to consult a neurologist. ...Read more

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I read that vitamin B12 deficiency can cause nerve damage .and nerve damage can cause psychosis and depression.Is it true ?

I read that vitamin B12 deficiency can cause nerve damage .and nerve damage can cause psychosis and depression.Is it true ?

Yes: That's why vegetarianism is so dangerous if you do not know EXACTLY what you are doing. There are also other causes of B12 deficiency and not just pernicious anemia from stomach disease. However, this is not a common cause of depression in young people who do not have physical weakness / numbness. There are a host of other physical causes; a skilled psychiatrist will pick these up. ...Read more

Nerve (Definition)

The brain and spinal cord communicates with what is occurring in the internal organs and limbs by nerve fibers where are like electrical wires with insulation (myelin) and the "copper" (axon). Within brain and spinal cord these nerves connect to other nerves via synapses on both axons and dendrites. A nerve can carry information regarding sensations, and ...Read more


Cerebrum (Definition)

Cerebrum essentially refers to the majority of the brain. Embryologically, it develops from the telencephalon, and together with the diencephalon, ...Read more