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Doctor insights on: Does Taking Tamoxifen For Breast Cancer Treatment Cause Cancer Of The Uterus

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Does taking tamoxifen for breast cancer treatment cause cancer of the uterus ?

Does taking tamoxifen for breast cancer treatment cause cancer of the uterus ?

Yes: Tamoxifen has been shown to increase the risk of uterine cancer, not unlike estrogen replacement therapy, with an incidence of ~1:500. However, this is almost-always caught at its earliest stage, with very high cure rates. If you compare the benefit of tamoxifen for either treating or preventing breast cancer compared to this risk, the benefit far outweighs the risk. ...Read more

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Dr. Barry Rosen
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Breast Cancer (Female) (Definition)

Breast cancer results when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. The growth occurs initially inside the ducts but eventually breaks outside into the breast tissue and ultimately spreads both to the lymph nodes in the armpit and via the bloodstream to other parts of the body. Because of the promoting affect of estrogen almost all breast cancer occurs in women and is a rarity in men. The unregulated growth is due to both inherited and acquired genetic defects. It is the most common malignancy in women but it often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast on an annual basis. ...Read more


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Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

Maybe: There is a slight increased risk of endometrial cancer of 1 in 500 chance reported. The benefits of tamoxifen in treatment of breast cancer is much higher than the risk of endometrial cancer. Ask your oncologist and ob-gyn how best to follow or watch for this potential risk. ...Read more

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Does taking tamoxifen for breast cancer treatment induce development of cancer of the uterus?

Yes: The chance is about 1% and treatment is hysterectomy. With such a low chance then tamoxifen is worth the risk. A gynecologist needs to keep track of the patient and any unusual bleeding evaluated. There are also other hormone alternatives with less risk. Check with your medical oncologist to see which drug is best for a particular patient. ...Read more

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Does taking tamoxifen for breast cancer treatment induce cancer of the womb?

Does taking tamoxifen for breast cancer treatment induce cancer of the womb?

Small risk: Tamoxifen is asociated with a small (less than 5%) risk of uterine cancers, women on tamoxifen require regular gynecologic checkups every 6-12 months and high-risk women may need ultrasound screeenings too. ...Read more

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When is tamoxifen for breast cancer treatment?

When is tamoxifen for breast cancer treatment?

Chemotherapy: Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. Furthermore, tamoxifen has been shown to be effective reducing the chance of developing breast cancer in high-risk women ("chemoprevention"). ...Read more

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Is tamoxifen a must for er/pr negative menstruating woman for breast cancer treatment?

Is tamoxifen a must for er/pr negative menstruating woman for breast cancer treatment?

No: This and similar medicines are anti Estrogens that block the receptors. So if the patient has negative receptors there is little benefit from the medication. So it's not a must. ...Read more

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Is it okay for an oncologist to do breast cancer treatment without tamoxifen?

Is it okay for an oncologist to do breast cancer treatment without tamoxifen?

Yes!: Tamoxifen is only useful in breast cancers which are estrogen receptor positive(er+). So tamoxifen is of no use if the tumor is er negative. Check your tumor's hormone receptor status and you will have the answer to your question>. ...Read more

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How has breast cancer treatment improved over time?

How has breast cancer treatment improved over time?

Many ways: In many ways it has improved. First of all withearlier detection there is less need of less aggressive excisions and chemo and radiotherapy. Have many advances in chemotherapy, for example it is a lot more targeted to specific receptors on the cancer. ...Read more

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Is there a less toxic alternative to chemotherapy for breast cancer treatment?

Yes: In some cases hormonal treatment can be as effective as chemotherapy. However if there is benefit from chemotherapy then it would be in addition to hormonal therapy. You should ask what percent benefit chemotherapy would give your circumstance and then decide if it's worth it to you to not accept that benefit. ...Read more

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Are there negative effects of breast cancer treatment/ mammography after a year? What should I expect?

Are there negative effects of breast cancer treatment/ mammography after a year? What should I expect?

Mammo is low risk: Treatment effects can vary significantly depending on what is done (type of surgery, radiation, chemo). Mammography should not have any significant effects, especially after one year. Mammograms are low dose radiation, but any radiation can increase cancer risk over the long term (decades). The cancer risk from mammograms is extremely low. Note that you are below the recommended screening age. ...Read more

Dr. Barry Rosen
4,214 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more