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Doctor insights on: Does Taking Tamoxifen Benefit Women With Cdis

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Does taking tamoxifen benefit women with cdis?

Does taking tamoxifen benefit women with cdis?

Yes.: Women with a history of ductal-carcinoma-in-situ (dcis) may have a 50% reduction in developing a second breast cancer when taking tamoxifen for 5 years ("chemoprevention"). Furthermore, following a lumpectomy, the combination of tamoxifen and radiation therapy may have a decreased risk of cancer recurrence in the affected breast greater than either therapy alone. ...Read more

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Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


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Does taking tamoxifen really benefit dcis?

Does taking tamoxifen really benefit dcis?

Yes, for ER+ DCIS: The addition of tamoxifen to surgery and radiation therapy for dcis significantly reduced the risk of invasive cancer on the same beast by 40 % and risk for in situ breast cancer on the other breast by 60 percent. ...Read more

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What are the common benefits of tamoxifen?

What are the common benefits of tamoxifen?

Kill cancer cells: Tamoxifen is a very effective chemotherapeutic agent to treat breast cancers that have the estrogen receptor. Tamoxifen may also be prescribed to prevent breast cancer in high-risk women: a 5-yr regimen may reduce the lifetime risk of breast cancer by 50%. ...Read more

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Do pre-menopausal women usually gain weight on tamoxifen?

Do pre-menopausal women usually gain weight on tamoxifen?

No: There have been many studies that have compared tamoxifen to placebo, demonstrating it's effectiveness treating breast cancer; none of these studies, to my knowledge, ever showed any difference between tamoxifen and placebo regarding weight gain. Nevertheless, as many as 10% of women on tamoxifen do report weight gain. This may be due to post-chemotherapy effects or menopause, as well. ...Read more

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I read that premenapausal women can get osteoporosis from tamoxifen, but postmenapausal cannot, is this true?

I read that premenapausal women can get osteoporosis from tamoxifen, but postmenapausal cannot, is this true?

In certain group: Tamoxifen is preserving bone density/decrease bone loss in postmenopausal women and in women who developed chemotherapy-induced amenorrhea. However, in premenopausal women who continued to menstruate after adjuvant chemotherapy, tamoxifen usage was associated with bone loss. ( jco 2006). ...Read more

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Why d & c is needed if a woman does not have no bleeding and thinks she menopausal because of her advance age which is 54year. Currently on tamoxifen?

Why d & c is needed if a woman does not have no bleeding and thinks she menopausal because of her advance age which is 54year. Currently on tamoxifen?

Not sure: Tamoxifen increases your risk of uterine cancer. If you had an ultrasound that showed thickened uterine lyning, your doctor may want to do a d;c to check for precancerous condition of your uterus. Without an abnormal ultrasound and without postmenopausal bleeding, i can't think of any reason why you need a d;c. ...Read more

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Why women taking Tamoxifen suffer from the risk of developing other cancers of the reproductive tract in comparison to all other women ?

Why women taking Tamoxifen suffer from the risk of developing other cancers of the reproductive tract in comparison to all  other women ?

Hormone effect: In the breast tamoxifen blocks any estrogen activity but in the uterus it is just the opposite where tam stimulates the uterine lining just like estrogen. This can causes overgrowth of the lining (endometrial hyperplasia) which is a risk for cancer. The same risk is present with hormone replacement with estrogen only which is why progesterone needs to be given as well with HRT. ...Read more

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Oncologist started me on Effexor (venlafaxine) XR for the hot flashes from tamoxifen.Taking it for 1 week extremely tired & nausea.Will benefits outweigh sideeffect?

Oncologist started me on Effexor (venlafaxine) XR for the hot flashes from tamoxifen.Taking it for 1 week extremely tired & nausea.Will benefits outweigh sideeffect?

Probably not: Nausea and fatigue are common side effects of effexor (venlafaxine). They can resolve with continued use of the med but often require that the Effexor (venlafaxine) be stopped. There are other meds that can help the hot flashes. ...Read more

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A female has pcos taking clomophen and tamoxifen and metformin has elevated liver enzymes what is the cause?

A female has pcos taking clomophen and tamoxifen and metformin has elevated liver enzymes what is the cause?

Multiple reasons: It is possible that the metformin affected that. But...Many women with pcos have high insulins and sugars and this leads to chronic fatty liver which is the more common reason for those findings. An ultrasound of the liver would help. ...Read more

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Is combined tamoxifen plus hormonal therapy more effective in pre or postmenopausal women and why?

Is combined tamoxifen plus hormonal therapy more effective in pre or postmenopausal women and why?

Tamoxifen: We don't give tamoxifen in combination with hormone replacement in the us. Occassionally use vaginal very low dose estrogen cream for vag dryness and tell pts to use a little as they can to relieve symptoms. Blocking hormones and giving them at same time does not make much sense. ...Read more

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Will nolvadex (tamoxifen) in women affect their birth control?

Will nolvadex (tamoxifen) in women affect their birth control?

YES: Nolvadex (tamoxifen) is used for breast cancer patients it is antiestrogen type drug it will affect ovulation it will not be advisable to get pregnant because of potential carcinogenic effect. ...Read more

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Female, 32 years old, IDC with two tumors, one 1.4X1.7 and the other .5. Bx results ER+/PR-/HER2-. Ki67 is 50. Plan is mastectomy and tamoxifen for 5 years. Question is does the patient need chemotheraphy as well.

Female, 32 years old, IDC with two tumors, one 1.4X1.7 and the other .5.  Bx results ER+/PR-/HER2-.  Ki67 is 50.  Plan is mastectomy and tamoxifen for 5 years.  Question is does the patient need chemotheraphy as well.

What is nodal status: This is an area of controversy. If lymph nodes contain tumor, the answer is universally yes. If they do not have tumor, many oncologists would say with young age, tumor over 1 cm in size, and multifocal tumors, YES to chemotherapy. Remember that each cancer is unique, and only the doctors that have all of the information can give you the best recommendation. Good luck! ...Read more

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On tamoxifen having several issues with ovarian cysts and pelvic pain. No chance of having children. Would i benefit from removal of my ovaries?

On tamoxifen having several issues with ovarian cysts and pelvic pain. No chance of having children. Would i benefit from removal of my ovaries?

Not necessarily: There are multiple issues in your question and it would be best for you to discuss your symptoms with the doctor presribing your tamoxifen in conjuction with your gynecologist. ...Read more

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I have been on tamoxifen for almost five years. My ankle is very sore and a bit swollen. Am a 51 year old female. Should I be concerned of blood clot?

I have been on tamoxifen for almost five years. My ankle is very sore and a bit swollen.  Am a 51 year old female. Should I be concerned of blood clot?

Yes: Tamoxifen while use in ER+ patients is an excellent anti-estrogen blocking the receptors for allowing cell proliferation acts elsewhere as an estrogen. It is known to cause blot clots in the legs of some patients and endometrial profiferation in others that can lead to endometrial Ca. You should probably have been taking some mild bold thinners and notify your physician about the swelling. ...Read more

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Is combined tamoxifen plus hormonal therapy better for breast cancer in pre or postmenopausal women?

Estrogen supression: In general, aromatase inhibitor is only indicated for postmenopausal women ;not for premenopausal; while on the other hand, tamoxifen can be given either in pre or postmenopausal. Only thing is that tamoxifen can cause a little bit higher risk for complication -i.e. Risk for blood clots and risk for develping uterine cancer- when used in older population- age of -65 Y.O. Or above. ...Read more

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43 yo female 1.5 CM stage 1 breast ca, idc, er/pr+, node neg, lumpectomy with neg margins, no lvi, oncotype score 11. Chemo+rt+tamoxifen or no chemo?

43 yo female 1.5 CM stage 1 breast ca, idc, er/pr+, node neg, lumpectomy with neg margins, no lvi, oncotype score 11. Chemo+rt+tamoxifen or no chemo?

ARR - non-binary: Using adjvuant online! and making some assumptions for missing data: there is a 25% risk of relapse, tamoxifen absolute risk reduction (arr) is 9%, chemo arr 14%, combo (chemo+tam) is 18% arr. Combo-chemo is 18-14% is 4% absolute benefit from chemo. This low benefit is confirmed with oncotype DX recurrence score (low risk). So, the decision is non-binary, but rather about the arr benefit. ...Read more

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Is tamoxifen a must for er/pr negative menstruating woman for breast cancer treatment?

Is tamoxifen a must for er/pr negative menstruating woman for breast cancer treatment?

No: This and similar medicines are anti Estrogens that block the receptors. So if the patient has negative receptors there is little benefit from the medication. So it's not a must. ...Read more

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Is tamoxifen safe and can I take it? I am a 67-year-old white female living alone. Last year i had early catch stage-1 breast cancer. I next had a lumpectomy and only one treatment of chemotherapy. I was scheduled for four treatments. The side affects

Is tamoxifen safe and can I take it? I am a 67-year-old white female living alone.  Last year i had early catch stage-1 breast cancer.  I next had a lumpectomy and only one treatment of chemotherapy.  I was scheduled for four treatments.  The side affects

If : If your breast cancer was estrogen receptor-negative then you will not benefit from hormonal adjuvant therapy like tamoxifen (actually women who are past their menopause should be on Arimidex (anastrozole) not tamoxifen) either way you will not benefit from those since your mass is estrogen receptor negative. At 67 you should probably still get radiation as you still have a long life ahead of you...Especially with stage 1 cancer. You have to discuss these options with a breast surgeon... ...Read more

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My mom 66 just diagnosed with breast cancer, metastasis to bones, stomach&lung t3n2m1. Put on tamoxifen for 2 mnths.Can she benefit from surgery?Whats her survival rate in years?How to extend her life?

My mom 66 just diagnosed with breast cancer, metastasis to bones, stomach&lung t3n2m1. Put on tamoxifen for 2 mnths.Can she benefit from surgery?Whats her survival rate in years?How to extend her life?

Need more than that: Yes if primary tumor is not removed , yes she will debunking will help , needs more than tamoxifen , speak to the oncologist for chemotherapy . Recent advances in chemotherapy changing the survival rate from 23% for better . Good luck. ...Read more

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Who should avoid taking tamoxifen?

Blood clots: Pts with a history of blood clots and/or a history of abnormal pap smears should not take tamoxifen. If there is a family history of clotting disorders or uterine cancer, tamoxifen should not be used. ...Read more

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