Doctor insights on:
Does Sickle Cell Trait In A Parent Cause Pyelonephritis
This is a genetic disorder in which hemoglobin is abnormally made., more common in people of african descent. This abnormality causes red blood cells to become stiff and fall apart. This can cause very specific symptoms: pain, pneumonias, strokes, spleen problems, and many other problems. Some have mild disease, some ...Read more
99+% yes: The answer is yes, but there is always a chance of a new mutation (rare). In which case one of the parents might not have trait. There is also hemoglobin c which can combine with hemoglobin s to give a very similar clinical disease (hemoglobin sc disease). You can also have sickle beta thalassemia which is very similar to sickle cell disease. But only one parent has to have sickle trait. ...Read more
Do both parents have to have the actual sickle cell trait in order for the child to have sickle disease sc?
One has S/One has C: Parents have 2 genes at a given gene location in their dna. They have a carrier state if one gene is normal and one abnormal.In sickle trait the pair is sn, in c trait the pair is cn. For a child to have sc (sickle c) they get the s from one and the c from the other. If one parent is sc and the other sn(sickle trait), you could have ss, sn or sc. ...Read moreSee 1 more doctor answer
Do both parents have to have the actual sickle cell trait in order for the child to have sickle disease sc or not?
Sort of: Sickle cell disease can include at least 3 different conditions. 2 parents with sickle trait can have a child with sickle cell anemia. 1 parent with sickle trait and 1 with hemoglobin c trait, another abn hgb, have a 1/4 chance of a child with sc disease, while 1 with sickle trait and 1 with thalassemia trait have a 1/4 chance of a child with sickle/thalassemia. All are called sickle cell disease. ...Read moreSee 2 more doctor answers
Varies: Sickle cell disease is a recessive disease. That means you have to have two of the disease genes to create the disease. Because you both have the trait (ss) that means there are 3 possibilities for your baby. 1) ss sickle cell disease - 25% 2) ss-sickle cell trait-50% risk 3) ss-no sickle cell mutation-25%. Hope this helps. ...Read more
Highly unlikely...: It is theoretically possible for someone to acquire a new mutation (de novo mutation) that is not inherited from a parent, but this has not been described for the sickle cell mutation. Statistically speaking, if you have sickle cell trait, one your biological parents also has to have it. ...Read moreSee 1 more doctor answer
New mutation: Sickle cell trait is almost always caused by a gene passed down from one parent. The parent may not even know he or she has it. Rarely, a new mutation can also occur-- a child's gene changes on its own, meaning that they didn't get it from a parent. I could not find the exact rate of these new mutations. It's rare, but it can at least theoretically happen. ...Read moreSee 1 more doctor answer
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