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Doctor insights on: Does Prednisone Make You Tired

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Dr. Bennett Machanic
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Dr. Thomas Namey
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Prednisone (Definition)

Prednisone is a synthetic cortisone. The body makes cortisone, a natural hormone made in adrenal glands. The body converts it to Hydrocortisone to become active. 25 mg of cortisone has about same effect as 5 mgm prednisone. The average person would produce 3-6 mg of pred daily. So why use a substitute? The synthetic has more anti-inflammatory effect; but has less effect ...Read more


Dr. Bennett Machanic
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I feel very tired all the time. I am taking 5mg prednisone daily plus 2x seretide 500. Is tiredness a side effect?

I feel very tired all the time. I am taking 5mg prednisone daily plus 2x seretide 500.  Is tiredness a side effect?

Not likely . . .: Seretide is sold in states as serevent (salmeterol), which along w/prednisone, suggests that you have either COPD or asthma. Feeling tired all the time isn't really a side effect of these meds (if anything, it's opposite effect of what's experienced w/prednisone). Therefore you need to go see your family doc (or who prescribed these meds) and tell him/her what you wrote. Perhaps not enough o2. ...Read more

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Why does prednisone cause excessive urination and sugar craving and excess tiredness? I get this every time I take it. Anyway to curb sx?

Why does prednisone cause excessive urination and sugar craving and excess tiredness?  I get this every time I take it.  Anyway to curb sx?

Different Steroid: Steroids influence many of your bodies functions strongly and broadly. If you are having consistent problems with side effects from the prednisone. Talk to your doctor about other options when you require treatment with steroids. ...Read more

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Dr. Bennett Machanic
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Can prednisone make you tired?

Can prednisone make you tired?

Yes, but...: Different people have different reactions to prednisone. Prednisone can make a person tired, fussy, excited, irritable, etc... However, many illnesses can make a person tired, so one cannot simply blame tiredness on the Prednisone (the doctor can consider the various causes of the tiredness). ...Read more

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Can coming off prednisone make you tired and weak? Been tapering for 2 weeks. Last dose was Tuesday 5 mg. How long should this last for?

Can coming off prednisone make you tired and weak? Been tapering for 2 weeks. Last dose was Tuesday 5 mg. How long should this last for?

Reevalution: Prednisone is used to treat a variety of conditions. Worsening fatigue as Prednisone is tapered may be a sign that the original condition being treated may be flaring. Ante-evaluation would be in order. ...Read more

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Can prednisone make a person tired?

Yes but why on pred: It depends why you are on prednisone. That may be the reason for your fati gue. Prednisone can interfere with quality sleep and this can cause fatigue. You can discuss your fatigue with your physician. Often daytime fatigue is due to poor quality of sleep and a sleep study may help. ...Read more

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I feel tired and sad all the time since my diagnosis. Can mtx and prednisone make you feel this way?

I feel tired and sad all the time since my diagnosis. Can mtx and prednisone make you feel this way?

Treatment effect: Yes. Steroids can affect yr psyche and mental well being. Discuss with your doctor. At age 23, you don't need those 2 meds in my opinion. They can have some serious long term effects. ...Read more

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Non-fasting blood sugar was 162. Had been on prednisone. Could high blood sugar make someone feel tired a lot? Am not diabetic (yet?)

Non-fasting blood sugar was 162. Had been on prednisone. Could high blood sugar make someone feel tired a lot? Am not diabetic (yet?)

Not the right test: You need to have blood glucose tested after an 8 hour fast. Alternatively you could get an A1c test and either would be more useful in deciding the diagnosis of diabetes. Your tiredness is more likely due to the issue for which you are taking prednisone. ...Read more

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Can prednisone cause someone to become extremely tired out of nowhere?

Yes, talk to doc: High-dose prednisone can cause many side effects. You may get hyper or very tired, euphoric or depressed. When it is stopped, you may feel even more tired. If you have been on prednisone for many months, your adrenal gland may stop working leading to a transient adrenal failure. Note also that the disease condition for which prednisone is prescribed may be be a factor. Call your doc. ...Read more

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Dr. John Feola
865 doctors shared insights

Liquid Pred (Definition)

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Dr. Bennett Machanic
Board Certified, Neurology
46 years in practice
47M people helped
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