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Doctor insights on: Does Prednisone Make You Gain Weight

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Why does prednisone make you gain weight and how come diet and exercise won't help?

Why does prednisone make you gain weight and how come diet and exercise won't help?

Fluid retention : Steroids affect how your body stores fat and glucose so can literally cause you to gain weight on top of excessive appetite/water retention along with metabolic changes in fat and glucose metabolism. It also increase fluid retention. ...Read more

Dr. Thomas Namey
2,506 doctors shared insights

Prednisone (Definition)

Prednisone is a synthetic cortisone. The body makes cortisone, a natural hormone made in adrenal glands. The body converts it to Hydrocortisone to become active. 25 mg of cortisone has about same effect as 5 mgm prednisone. The average person would produce 3-6 mg of pred daily. So why use a substitute? The synthetic has more anti-inflammatory effect; but has less effect ...Read more


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I just lost 90 pounds and now i got put on prednisone and i'm gaining weight what can I do please help me?

People commonly: Eat more and gain weight when on prednisone, particularly at high doses. I'm assuming you lost the 90 pounds intentionally and are worried, and appropriately so, about the recent weight gain. You can still control your weight through restricting your intake and exercising more, but it is difficult until the dose of Prednisone is decreased or discontinued. ...Read more

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Can one gain weight on 5 mg prednisone daily for several months if they watch their diet and exercise? Can I still lose while on this?

Can one gain weight on 5 mg prednisone daily for several months if they watch their diet and exercise? Can I still lose while on this?

Work on it: Corticosteroids like the Prednisone do have a tendency to cause weight gain. You are on the right track if you can watch your calories and exercise. The medication may increase your appetite, so it will take discipline. Eat healthy. The provider prescribing the medicine may be able to advise you on diet and exercise to reduce the possibility of weight gain. ...Read more

Dr. John Feola
943 doctors shared insights

Liquid Pred (Definition)

Liquid Pred is a corticosteroid which is a kind of ...Read more


Dr. Louis Gallia
938 doctors shared insights

Deltasone (Definition)

Deltasone is a corticosteroid which is a kind of ...Read more