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Doctor insights on: Does Pernicious Anemia Run In Families

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Does pernicious anemia run in families?

Does pernicious anemia run in families?

Rarely: Most cases of pernicious anemia are acquired due to immune destruction of the stomach cells which produce intrinsic factor. This results in poor absorption of B12 from food and patients get anemic as a result. Only rarely can children get this as a congenital causes. ...Read more

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Pernicious Anemia (Definition)

It is a decline in the amount of red cells in the circulation as a result of impaired production in the bone marrow resulting from a lack of vitamin b12. This is most commonly as a consequence of impaired absorption due to an autoimmune condition affecting the stomach lining. If untreated, it may also lead to brain and spinal cord problems. It is easily ...Read more


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Does hashimoto's run in families? And does it have potential to cause pernicious anemia?

Does hashimoto's run in families? And does it have potential to cause pernicious anemia?

Yes! To both!!: Both may be autoimmune diseases and frequently are hereditary! Both are very easily diagnosed by lab tests! See your physician if you think you have either of these illnesses! ...Read more

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I tested positive for ana, and have a family history of lupus and pernicious anemia. What do I do now?

Wait: Many normal people have low-titer positive ana's and they mean nothing by themselves. If you have symptoms suggestive of lupus, continue the workup and consider seeing a rheumatologist. If you have a family history of pernicious anemia, you'd do well to get a serum B12 assay every few years. ...Read more

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Is there a specific blood test to diagnose pernicious anemia? I have a family history. My doctor told me I have borderline B12 deficiency.

Is there a specific blood test to diagnose pernicious anemia?  I have a family history. My doctor told me I have borderline B12 deficiency.

Pernicious anemia: Yes your doctor can run a battery of tests including a cbc, peripheral blood smear, a serum b 12 level, and a reticulocyte count. These usually will help to diagnose the condition. Sometimes methylmalonic acid and homocysteine levels will be drawn to help with the diagnosis. ...Read more

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Can pernicious anemia be cured?

Can pernicious anemia be cured?

Not usually.: Classical pernicious anemia is caused by auto-antibodies against intrinsic factor-producing parietal cells of the stomach. Treatment is lifelong vitamin B12 administration, which is safer than using immunosuppressive medications that could lead to severe infections. Other kinds of B12 deficiency can possibly cured depending on the cause. ...Read more

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Is pernicious anemia life-shortening?

Is pernicious anemia life-shortening?

Typically not: Pernicious anemia when treated with life long B12 replacement confers a normal lifespan. There is an increased risk of stomach cancer in some cases which can affect survival times. ...Read more

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Could pernicious anemia shorten life?

Probably no: If you have pernicious anemia you do not absorb B12 effectively. That is easily fixed with either B12 injections or large B12 oral doses daily. Unfortunately, patients with B12 deficiency often have other associated autoimmune issues that develop. In general though, pa alone will not shorten life as long as you treat it correctly. ...Read more

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What are the symptoms for pernicious anemia?

They can be subtle.: Pernicious anemia is caused by vitamin B12 deficiency. The name refers to the fact that symptoms can come on so slowly that you might not be aware of them. If present, pa can cause fatigue due to anemia, mental changes that can include memory deficits or dementia, or nerve damage that causes numbness in the feet and possible gait disturbances. You can get all of them, or none and have pa. ...Read more

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What are the causes of symptoms in pernicious anemia?

What are the causes of symptoms in pernicious anemia?

Lack of vitamin B12: Pernicious anemia is due to a lack of vitamin b12. B12 is necessary for the normal function of the nervous system and the formation of red blood cells. ...Read more

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How to treat pernicious anemia?

How to treat pernicious anemia?

B-12 deficiency: Unless there is an intestinal parasite, we usually just do blood studies to confirm and supplement vitamin b-12 using 1000 mcg injected monthly, i.M. Some pts will absorb sufficient amounts by mouth or intranasal routes, but most efficient to inject. ...Read more

Dr. Steven Ginsberg
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Anemia (Definition)

Anemia refers to any condition where there is a decrease in the red blood cells in the body. There are numerous causes of anemia but they can basically be broken down into 3 categories: decreased production of red blood cells increased destruction of red ...Read more