Doctor insights on:
Does Monosodium Glutamate Cause Cancer
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
Possibly many ways.: This is the active ingredient in chili peppers that causes a burning sensation. It binds to the vanilloid receptor subtype 1 (vr1), which triggers a temperature oriented inflammatory reaction. Some of its effects on cancer are inconclusive, like stomach cancer. It appears to have proposed effects of other cancers, like breast cancer by causing apoptosis by affecting the egfr/her-2 pathway. ...Read moreSee 1 more doctor answer
Glutamate metabolism dysregulation is associated with cancer. What comes first, glutamate metabolism dysregulation or cancer?
Not simple: Cancer is ultimately a genetic disease, that is cancer cells have mutations not found in normal cells. Some mutations are in genes affecting metabolic pathways, including glutamate metabolism, and the abnormal metabolism may contribute to the progression to invasive cancer. So your question is sort of a chicken and egg one; ultimately it is the mutation that is what starts a cancer. ...Read more
Yes. Great Question!: The Amino Acid glutamate plays a central role in nitrogen metabolism & participates in multiple biochemical pathways. Disease examples: autoantibodies to the glutamate receptor kill neurons via activation of the receptor ion channel. Anti-nmda receptor encephalitis is a treatment-responsive inflammatory encephalopathic autoimmune disease associated with anti-nmda receptor antibodies. ...Read more
Not known so...: Msg has not been shown to cause or adversely affect hypertension. It is a rather common food additve/sweetener and fortunately relatively safe, in moderation of course. If you have problem with hypertension, obviously you should consult doc for eval and treatment. It is not necessary that you advoid msg, but too much of anything is not good. Consult your doc.Good luck. ...Read more
Can autoantibodies against glutamine synthetase and/or glutamate dehydrogenase cause glutamate metabolism disorders?
Still searching: Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. I am unble to find references in my search so far as to autoantibodies to these but see comment. ...Read more
Maybe: Whether alcohol abuse is an important risk factor for pancreatic cancer isn't clear; smoking clearly is. Abuse alcohol though and you're asking for chronic pancreatitis, a confusingly-named lifetime severe pain syndrome involving damage to the deep nerves of the area. You don't want that, or any of several other unpleasant sequelae. Best wishes; make smart decisions & drink moderately if at all. ...Read moreSee 2 more doctor answers
Which glutamate receptor(s) are affected negatively by monosodium glutamate: ampa, nmda, and/or kainate?
Not likely.: Neoprene is the trade name of polychloroprene, a rubber-like polymer made by chemically treating chloroprene (2-chloro-1, 3-butadiene) so that each molecule hooks up to another in long chains. Chloroprene is considered possibly carcinogenic to humans, but virtually all the chloroprene is used up in the conversion to the polymer. The amount left behind is probably too miniscule to pose any risk. ...Read more
How does subcutaneous alcohol injection kill certain tumors when alcohol is known to cause certain cancers? Seems strange
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