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Doctor insights on: Does Methotrexate Work Well To Help With Psoriasis

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Dr. Thomas Namey
1,030 doctors shared insights

Psoriasis (Definition)

An autoimmune disease involving the skin, nails, and occasionally the joints. It is not contagious. There are several types of skin lesions, most common variety being large red scaly itchy plaques on extensor surfaces such as elbows and knees. Psoriasis can be controlled by a wide variety of medications, but a cure has ...Read more


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How well does methotrexate work on psoriasis?

How well does methotrexate work on psoriasis?

Psoriasis : Methotrexate is a terrific therapy for severe psoriasis. It works well, is very inexpensive and is relatively safe when its effects are carefully monitored. ...Read more

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Psoriasis+psor. Arthritis. Methotrexate 15mg for 2 mos. Already+humira weekly. Dr say stelera no good for arthr... Says remicade (infliximab) or enbrel maybe. Ok?

Psoriasis+psor. Arthritis. Methotrexate 15mg for 2 mos. Already+humira weekly. Dr say stelera no good for arthr... Says remicade (infliximab) or enbrel maybe. Ok?

Nod to others:: Humira is a tnfa antibody, and is similar to envbrel. Remicade (infliximab) is an antibody to the tnfa receptor, so it works differently. But I would have tried you on leflunomide, and oral drug, before starting biologics. ...Read more

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Humira and Methotrexate are not working for my psoriasis. I asked the doctor about Stelara (ustekinumab). Dr. hasn't seen good results w/other patients on Stelera so doesn't use it. What would you recommend?

STELERA/HUMIRA/METHT: Well if you have no improvement with Humira (adalimumab) and methtrexate, then there is no harm in trying stelera. Discuss with your doctor that it is not working, so what is the harm in trying if stelera will work for you
otherwise you can get a second opinion from another dermatologist. ...Read more

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Can methotrexate treat psoriasis?

Can methotrexate treat psoriasis?

Yes. Agree, but....: Methotrexate can be very effective. However, the first studies raising the specter of liver disease came from psoriasis patients on daily low dose oral mtx!. The first pass effect is dangerous for the liver. Mtx cannot be adjudicated aqs an oral drug. Absorption is variable (40-90%), causes GI upset, and hits the liver first. I only use subcutaneous mtx once weekly. This is the safest! ...Read more

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What are the side effects of methotrexate for psoriasis worth taking the risk?

What are the side effects of methotrexate for psoriasis worth taking the risk?

Worth the risk: For more severe psoriasis, Methotrexate is definitely worth the risk and really has fairly low risk. Side effects include GI irritation, hair loss, reduced blood counts and liver inflammation. All of these are uncommon. ...Read more

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I am on methotrexate for severe psoriasis. Can I come off it as I have read of serious side effects. Thanks?

Yes, but: The risk of methotrexate toxicity is fairly low and your psoriasis will flare if you discontinue it. Before doing anything you should discuss this with your dermatologist. ...Read more

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My Dr. wants me back on methotrexate b/c of inflammation levels in my body. What's your opinion on inflammation in the body & psoriasis?

My Dr. wants me back on methotrexate b/c of inflammation levels in my body. What's your opinion on inflammation in the body & psoriasis?

MTX in psoriatic: Arthritis is a proven treatment
http://www.ncbi.nlm.nih.gov/pubmed/24566842
there is toxicity wtih it but it requires years to decades of MTX use. The newer antibody treatments are probably stronger and less toxic. ...Read more

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My age is 29yrs. For psoriasis, I'm taking methotrexate 7.5 mg since 7yrs. Using this, what are the side effects to me in long term. Plz suggest?

My age is 29yrs. For psoriasis, I'm taking methotrexate 7.5 mg since 7yrs. Using this, what are the side effects to me in long term. Plz suggest?

Probably not much: This is a small dose of methotrexate. Assuming you have blood tests to screen for medication toxicity and these tests are normal, the long term risk is small. Make sure blood is screened for liver toxicity and reduced blood counts every 3 months. ...Read more

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Started methotrexate on feb.1st for psoriasis. No luck yet! Any other suggestions that might help. I have MS ... So I'm stuck :(?

Started methotrexate on feb.1st for psoriasis. No luck yet! Any other suggestions that might help. I have MS ... So I'm stuck :(?

Consider BG-12: Bg-12 is set to be released this month for the treatment of multiple sclerosis. It has been approved in germany since 1994 for the treatment of psoriasis. It's advantage lies in action which is immunomodulatory and not immunosuppressive. Hence, the side effect profile is a bit more favorable. Ask your neurologist and coordinate with the rheumatologist to see if this is an appropriate choice. ...Read more

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Humira (adalimumab) every 2 weeks stopped working&got a bad psoriasis flare-up... Now on humira (adalimumab) weekly w/15mg methotrexate but still have bad psoriasis. U recommend?

Psoriasis: While Humira is an excellent therapy for severe psoriasis, there are times when it stops working. Another option for you may be stelara (ustekinumab) which is also an injectable treatment which works a little differently than does Humira and is extremely effective in many patients. ...Read more

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I am on 20mg Methotrexate for Psoriasis for the last 10 years. Can I give it up without weaning off without side effects. Thanks?

Talk to derm: It is best for you to work with your doctor on getting your off of methotrexate and discuss potential options should the psoriasis recur. ...Read more

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What's more effective for pustular psoriasis, methotrexate or enbrel (etanercept)?

Both: Both can be effective, personally I feel Enbrel (etanercept) is safer. There are other options. Talk it over with your dermatologist. ...Read more

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Does methotrexate help with psoriatic psoriasis.stiffness in the joints, I am on 20mg weekly. Thanks?

Does methotrexate help with psoriatic psoriasis.stiffness in the joints, I am on 20mg weekly. Thanks?

It can: Typically, at any particular dose of methotrexate, it will take about 8 to 12 weeks to see what the level response will be with that dose. About 2/3rds of people will get a 20 to 50% decrease in joint pain/swelling within 3 months once the best/ the safest dose is determined. Sometimes even a better response! If you get < 20% improvement your MD may discuss options of a higher dose vs other meds. ...Read more

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On enbrel 50mg weekly for 3 mos, methotrexate 25mg weekly 3mos, arava (leflunomide) 20mg 1 month, still have psoriasis lesions. Is this possible&willl psor. Ever clear?

Still a bit early: So many of these medications requires several weeks or months to start working. Enbrel and Arava usually works around 3 months after starting it, and Methotrexate can take as long as 6 months before working.

I would give it another month, then reconsider. There are other good medicines that could work for you including stelara (ustekinumab). ...Read more

Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


Dr. Robert Lowe
341 doctors shared insights

Rheumatrex (Definition)

Rheumatrex ...Read more