Doctor insights on:
Does Methotrexate Work Well To Help With Psoriasis
An autoimmune disease involving the skin, nails, and occasionally the joints. It is not contagious. There are several types of skin lesions, most common variety being large red scaly itchy plaques on extensor surfaces such as elbows and knees. Psoriasis can be controlled by a wide variety of medications, but a cure has ...Read more
Psoriasis+psor. Arthritis. Methotrexate 15mg for 2 mos. Already+humira weekly. Dr say stelera no good for arthr... Says remicade (infliximab) or enbrel maybe. Ok?
Humira and Methotrexate are not working for my psoriasis. I asked the doctor about Stelara (ustekinumab). Dr. hasn't seen good results w/other patients on Stelera so doesn't use it. What would you recommend?
Well if you have no improvement with Humira (adalimumab) and methtrexate, then there is no harm in trying stelera. Discuss with your doctor that it is not working, so what is the harm in trying if stelera will work for you
otherwise you can get a second opinion from another dermatologist. ...Read more
Yes. Agree, but....: Methotrexate can be very effective. However, the first studies raising the specter of liver disease came from psoriasis patients on daily low dose oral mtx!. The first pass effect is dangerous for the liver. Mtx cannot be adjudicated aqs an oral drug. Absorption is variable (40-90%), causes GI upset, and hits the liver first. I only use subcutaneous mtx once weekly. This is the safest! ...Read more
I am on methotrexate for severe psoriasis. Can I come off it as I have read of serious side effects. Thanks?
My Dr. wants me back on methotrexate b/c of inflammation levels in my body. What's your opinion on inflammation in the body & psoriasis?
My age is 29yrs. For psoriasis, I'm taking methotrexate 7.5 mg since 7yrs. Using this, what are the side effects to me in long term. Plz suggest?
I was taking methotrexate a year for psoriasis & it helped a ton. When I stopped taking it my psoriasis went into overdrive & little spots all over?
Hi, see a Rheumatologist or Dermatologist for newer treatment options.
Good luck. ...Read more
Started methotrexate on feb.1st for psoriasis. No luck yet! Any other suggestions that might help. I have MS ... So I'm stuck :(?
Consider BG-12: Bg-12 is set to be released this month for the treatment of multiple sclerosis. It has been approved in germany since 1994 for the treatment of psoriasis. It's advantage lies in action which is immunomodulatory and not immunosuppressive. Hence, the side effect profile is a bit more favorable. Ask your neurologist and coordinate with the rheumatologist to see if this is an appropriate choice. ...Read more
I am on 20mg of methotrexate for psoriasis. My rheumatoligist told me to stay on it or if I wish to come off it. Is it safe to do so thanks?
Talk to doctor: This is an issue which needs be addressed by your doctor. ...Read more
I've had psoriasis for 22yrs, tests came back I have inflammation in my body. What harm could inflammation do in my body if I refuse methotrexate?
Humira (adalimumab) every 2 weeks stopped working&got a bad psoriasis flare-up... Now on humira (adalimumab) weekly w/15mg methotrexate but still have bad psoriasis. U recommend?
Psoriasis: While Humira is an excellent therapy for severe psoriasis, there are times when it stops working. Another option for you may be stelara (ustekinumab) which is also an injectable treatment which works a little differently than does Humira and is extremely effective in many patients. ...Read more
With close monitorin: With close monitoring.Get a more detailed answer ›
I am on 20mg Methotrexate for Psoriasis for the last 10 years. Can I give it up without weaning off without side effects. Thanks?
Both: Both can be effective, personally I feel Enbrel (etanercept) is safer. There are other options. Talk it over with your dermatologist. ...Read more
Does methotrexate help with psoriatic psoriasis.stiffness in the joints, I am on 20mg weekly. Thanks?
It can: Typically, at any particular dose of methotrexate, it will take about 8 to 12 weeks to see what the level response will be with that dose. About 2/3rds of people will get a 20 to 50% decrease in joint pain/swelling within 3 months once the best/ the safest dose is determined. Sometimes even a better response! If you get < 20% improvement your MD may discuss options of a higher dose vs other meds. ...Read more
On enbrel 50mg weekly for 3 mos, methotrexate 25mg weekly 3mos, arava (leflunomide) 20mg 1 month, still have psoriasis lesions. Is this possible&willl psor. Ever clear?
Still a bit early:
So many of these medications requires several weeks or months to start working. Enbrel and Arava usually works around 3 months after starting it, and Methotrexate can take as long as 6 months before working.
I would give it another month, then reconsider. There are other good medicines that could work for you including stelara (ustekinumab). ...Read more
Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more
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