Doctor insights on:
Does Iron Build Up In Hemochromatosis Impact The Lungs
No: They are usually spared unless the left ventricle of the heart fails and blood accumulates under pressure in the lungs. ...Read more
Deoxygenated blood enters the lungs from the right side of the heart and travels to the lungs. When you inspire, oxygen flows into the lungs, transverses the capilliares and attaches to hemoglobin down a gradient. At the same time, co2 diffuses into the capilaries and is expelled with exhalation. Oxygen rich blood then flows to the left side of the heart and into the ...Read more
Too much bodily iron: As a result of the inability to increase iron loss, iron overload is an inevitable response to increased iron entry into the body. This can occur by one of three mechanisms - nutritional intake, increased absorption, parenteral sources (i.e. Transfusions). Hemochromatosis is abnormally high absorption of iron as result of a genetic defect. Extra iron can be toxic. ...Read more
Transferrin sat: Your best screen is transferrin saturation. Many of us think that the current recommendation of 45% or more for women, 50% of more for men miss too many people. If you actually have evidence of liver troubles (elevated SGOT / SGPT, for example), think about getting a serum ferritin. With a family history, get the gene testing to know early. ...Read more
I have hemochromatosis but my iron levels are Ferritin 8 Iron 7 Transferrin 2.1 Transferrin Sat 13?
1 in 200: It's extremely common, and of all the common, serious diseases, it is the easiest to manage. If it's discovered relatively late, the person realizes they've had "the blahs" for years once phlebotomy removes the excess iron. ...Read more
Can be deadly: Over time, excesses of iron build up in major organs such as the heart, liver, pancreas, joints and pituitary. If the extra iron is not removed, these organs can become diseased, causing conditions like diabetes mellitus, irregular heart beat or heart attack, arthritis, cirrhosis of the liver or liver cancer, gall bladder disease, depression, impotence, infertility, hypothyroidism, hypogonadism. ...Read more
A few: Lack of energy, abdominal pain, memory fog, loss of sex drive, heart flutters, irregular heart beat. When symptoms are associated with hemochromatosis, these usually begin in men in their late 20’s to early 30’s. In women, symptoms usually start about 10-15 years after they stop having a period due to menopause, birth control pills or hysterectomy. ...Read more
Labs and Bx: Labs that include ferritin and transferrin saturation. All patients being evaluated for hhc should have c282y and h63d mutation analysis. This may help in determine risk for hhc but is not always diagnostic by itself. Lastly a liver biopsy with a iron index or MRI may help to confirm suspected cases. ...Read more
I have been diagnosed with hereditary hemochromatosis. I have had 8 phlebotomies and my iron level is still raising. Why?
Every time my son donates blood they tell him his iron is too high. This time it was 51. My uncle has hemochromatosis, should I be concerned.
I have been doing phlebotomy for hemochromatosis. I got my ferritin down to 50 then it went back up to 300! why?! do not drink low iron diet
In Hemochromatosis, your body absorbs too much iron. Even if your diet is low iron, as it should be, you can still over time accumulate iron in your tissues again since the underlying problem with iron metabolism is ever present.
Ferritin is also a marker of inflammation, and often rises during infection etc. If you have had any such issues lately, it could be a result of that as well. ...Read more
Can u have hemochromatosis if your blood tests show high iron and tsat levels in 2 out of 4 tests over 3 years - t'ferrin & ferritin levels are normal?
Proper testing: The transferrin saturation needs to be done on fasting blood samples. A cut-off of 45% is best used. If the ts > 45% on fasting specimens, although the ferritin might be normal, can be seen with some iron overload disorders including hemochromatosis. A normal fasting ferritin and tsast. ...Read more
Hi. I have been diagnosed with high iron level (244)and high saturation (79%)but normal ferritin (137)and no hereditary hemochromatosis. What do I have?
I have high iron levels (not hemochromatosis), can I take spirulina supplement? As it says it has 30x the iron of spinach.
Is it true that hemochromatosis patients have eyebrows that look empty towards the ends? (source: iron disorders institute)
Not worth pursuing: Your source misquotes the idi's book which mentions the hair loss due to endocrine disruption. It mentions loss of pubic hair as well; these are nonspecific changes and would be worthless in ruling hemochromatosis in or out. Routine chemical profiles pick common hemochromatosis up. Eyebrow-gazing isn't going to be productive for you or anyone else. Glad you're iron-alert though! ...Read more
Iron blood panel showed this: UIBC- 109 (low), Iron serum- 170 (high), Iron Saturation 63% (high). Is this hemochromatosis?
Suspicious: Further testing is necessary to definitively diagnose hemochromatosis. The elevated transferrin level makes it much more likely but the test should be repeated and you should have genetic testing for the C282Y gene. I suggest you see a hematologist or general internist for definitive testing. Thanks for trusting HealthTap! ...Read more
My serum iron was elevated at 241, however my ferritin, TIBC, and transferrin count were in the normal reference ranges. Is this hemochromatosis?
What you described is not necessarily hemochromatosis. There is a genetic for it that you may wish to get in consultation with your doctor. If you are otherwise healthy consider donating blood, it will reduce your iron and you will do a good deed. See this site for more info.
https://www. Nlm. Nih. Gov/medlineplus/ency/article/003488.htm ...Read more
My brother has hemochromatosis. My ferritin level is 169, iron is 243, tibc is 379, iron saturation 64. I'm 39 and still menstruating. Do I have hemochromatosis?
After phlebotomies for hereditary hemochromatosis ferritin is 3, sat is 14%, but iron 40 - is this id anemia?
Iron: Hereditary hemochromatosis is a condition where inherited mutation on the gene/s that regulates iron metabolism- this makes your body accumulates too much iron and as the result iron associated organ failure can develop. Therapy is phlebotomy to keep your ferritin around 20. I don't think we need to keep the iron to the level that you have. Discuss with your hematologist in detail. ...Read more
Is it possible for a person to get iron overload from eating a lot of meat but doesn't have gene for hemochromatosis?
Does hemochromatosis ever cause compensatory hyperventilation? Does this signal that heart damage from iron overload is already done?
The heart!: The heart is one of the last organs to be significantly damaged from hemochromatosis. Lfts indicationg liver damage, pancreatic, and gonadal dysfuction would occur first, as would joint issues caused by secondary hemochromatosis. Also, a female would never have this issue at 19! ...Read more
Isn't the diagnosis for hemochromatosis based on irish hemochromatosis? Other races like far east have different gene for iron overload
Let me help: Most hemochromatosis worldwide is caused by mutations at the hfe gene locus; most europeans with a worrisome mutation here have c282y, but there are other alleles at this locus, and several other less common loci. Further, having the gene won't give you the disease unless you actually get iron-overloaded, which is how we pick it up. Any primary care doc can diagnose & rx is easy. Stay proactive. ...Read more
Total iron binding capacity is high. Transferrin is high. Iron serum normal. Hemoglobin count low 12 any significance. Is it hemochromatosis?
If a person eats meat every day, about 8-10 oz of steak, but takes no iron supplements, could he end up with hemosiderosis or hemochromatosis?
Hemochromatosis is always hereditary or congenital? I have cirrhosis in the liver and moderate iron accumulation, which one caused the other one?
Need more info: How was diagnosis made? ferritin >200 in a female, with % iron bound >50%? Unfortunately, the liver bx is unreliable for determining amount of iron accumulation, as one area may be normal and another area may be very high. Were you found homozygous for specific predisposing genes? If not homozygous, it is not likely genetic. Have they started therapy? Look up N-acetyl cysteine in Wikipedia. ...Read more
I have hemochromatosis h63d, ferritin levels474 all iron teats show normal. Can I still take my buffer vit. C? Also aat level is at 70 any suggestions?
ferritin best shows your iron level, not serum iron. Yours is abnormally high, over 300 for males. You report h63d, a mutation with no effect if you have one normal gene, and a majority of homozygotes never develop symptoms. How was Alpha-1 Antitrypsin
measured? Deficiency may cause liver damage,
high ferritin, and increased risk of cancers. Are PFTs normal? Suggest GI consult. ...Read more
Should people with hemochromatosis avoid alcohol? I hear that alcohol can increase iron absorption.
If I have the single gene mutation (heterozygote) and am a "silent carrier" for hemochromatosis, will I become iron overloaded?
No: Hereditary hemochromatosis develops when you inherit two mutations, one on each of your hfe genes. You have just one. About 1/10 folks with northern european ancestry is a carrier. Carriers don't get iron overload. In fact, most folks with two hfe mutations do not get sick at all, even though for many we can see that they are accumulating a lot of iron. A mystery? Rather. But we're working on it. ...Read more
My iron sat increased from 20% to 44% in 2 years. ALT mildly elevated (64, 76)for 6 months and mild hepatomegaly. Doc said it may be hemochromatosis?
Get genetic test: The change in iron saturation suggests disturbance in iron metabolism, which in a young patient like you may be a sign of hereditary hemochromatosis. The rise in ALT suggests mild liver injury. You need a follow-up with genetic testing and more detailed liver and iron profiles ...Read more
My doc says 44% iron saturation is considered elevated and wants to test for hemochromatosis. Had iron studies due to elevated ALT. Is 44% bad?
Presuming you are talking about Transferrin saturation- 44% would be considered High Normal;
Ferritin levels would be more useful
There are multiple reasons to have elevated Transferrin saturation- only one of which is Hemochromatosis.
Liver dysfunction is one of the others- which may explain elevated ALT.
Discuss with ur doctor.
Good Luck ...Read more
Ferritin high 425 ug/l but iron & UIBC normal - has fatty liver disease - could this be hemochromatosis or is it the inflammation from liver disease?
Hemochromatosis: Nope. No connection.Get a more detailed answer ›
CBCs past 3 yrs show steady increase of iron, serum. Now outside normal range. Abdominal discomfort left side under bottom ribs. Hemochromatosis? Or?
Probably not: But hemochromatosis is fairly common, so the best thing to do is ask your PCP to check liver enzymes if you are experiencing abdominal pain, nausea, or lack of appetite. if the liver tests are abnormal, then imaging by way of an ultrasound may be indicated. If they are normal, it may be best to monitor your labs and symptoms over time ...Read more
I'm concerned I may have hemochromatosis. I have chronic fatigue, anxiety, occasional depression, symptoms that seem to suggest the "iron fist" & more?
I suspect you have looked this up on the web.
Make a list of your symptoms and concerns and see your doctor.
Your medical history will be recorded, you will be examined and appropriate labs will be ordered.
I hope everything turns out OK. ...Read more
If I have the double gene mutation (homozygous) for hemochromatosis but am not clinically iron overloaded (have high iron levels on lab results) at this time, can I develop iron overload later, such as in 2, 5, or 10 or more years later?
Hemachromatosis: The single gene carrier will likely not develop any symptoms or problems from increased iron absorption. You will still need to have regular blood work to check for increased iron, and not use any supplements with iron. If you have two genes, your chance is good that you will have high levels of iron, and possibly get damage from the extra iron. Timing is unknown, too many variables. ...Read more
Being predisposed to hemochromatosis, is it okay to take iron supplements for incredible fatigue possibly due to anemia?
Do not guess: Get checked out for anemia first and verify need for iron supplementation before taking any. Do not just guess. Also get thyroid checked out. Make sure to check free T3 (liothyronine) and reverse t3 (liothyronine). Ft3 (liothyronine) should be in upper range and rt3 (liothyronine) in lower range. ...Read more
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