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Doctor insights on: Does Inbreeding In Families Cause Hemophilia To Develop

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Does inbreeding in families cause hemophilia to develop?

Does inbreeding in families cause hemophilia to develop?

Not usually: Despite emphasis on hemophilia and royal families, rasputin's influence depended on common relatives among english/russian royalty. The well-known hemophilias are x-linked, passed through normal women with 2 xs to men with one. Inbreeding increases chances for matching up of rare, autosomal recessive mutations in spouses (e.g., cystic fibrosis, tay-sach's diseases). ...Read more

Dr. Susumu Inoue
121 doctors shared insights

Hemophilia (Definition)

Hemophilia is congenital deficency of factor 8,9 ,11 ...Read more


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What caused hemophilia in the British royal family?

Queen Victoria: She was a new mutation, on the evidence. One of her X-chromosomes when transmitted to her male descendants resulted in their getting the disease. It wasn't just the British royal family; they were intermarried, and the Tsar's failure to produce a healthy heir prevented a constitutional monarchy run by reasonable people in Russia. Random events have grave consequences. ...Read more

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What are some organizations that can help a family cope with a child's hemophilia?

Hemophilia groups: The hemophilia websites i find most valuable (and accurate) belong to the national hemophilia foundation and world federation of hemophilia. ...Read more

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My sister has a son with hemophilia, but there is no family history other than that, is this just bad luck?

Perhaps: Hemophilia a & b are x-linked recessive while c is usually autosomal recessive. So, it's possible that the mother was a carrier. However, about 1/3 of a & b cases are due to spontaneous mutation. ...Read more

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What type of mutation causes hemophilia?

What type of mutation causes hemophilia?

Hemophilia: A mutation on the x chromosome that affects the blood clotting factors viii or ix. ...Read more

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Can you tell me how bleeding cause hemophilia?

Can you tell me how bleeding cause hemophilia?

It dosent: The bleeding is not the cause of this condition but the sign of the disorder. The person with hemophilia lacks some of the factors responsible for clotting. Thus any bleeding lasts for a longer time and is more profound as compared to a person with normal clotting mechanisms. ...Read more

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What is the amino acid substitution that causes hemophilia?

It's not that simple: This isn't sickle cell anemia. A huge variety of different genetic mutations cause hemophilia A. The most common troublesome one is an inversion in intron 22. I'm sorry you had trouble finding an answer to this question, and perhaps you'll enjoy reading up on this complex but fascinating study. ...Read more

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What type of mutations that cause hemophilia a?

Gene on X-chromosome: Hemophilia a is a hereditary bleeding disorder where there is a deficiency in clotting factor viii (factor viii is needed for blood clotting). It is inherited on the x-chromosome (sex-linked). Men only have 1 "x", so if their "x" is mutated, they will have the disease. Women have 2 "x's", so they can have 1 mutated "x" and 1 normal "x", and be a carrier of the disease, with mild or no symptoms. ...Read more

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What causes hemophilia?

Genetic defect: Hemophilia is a bleeding disorder due to abnormal gene for clotting factor viii (hemophilia a) or ix (hemophilia b) that is on the x-chromosome and men inherit the defect from their mothers. Women are carriers and are rarely affected. ...Read more

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What gene causes hemophilia a, how is it inherited?

What gene causes hemophilia a, how is it inherited?

Gene for Factor VIII: Hemophilia a is a hereditary bleeding disorder where there is a deficiency in clotting factor viii (factor viii is needed for blood clotting). It is inherited on the x-chromosome (sex-linked). Men only have 1 "x", so if their "x" is mutated, they will have the disease. Women have 2 "x's", so they can have 1 mutated "x" and 1 normal "x", and be a carrier of the disease, with mild or no symptoms. ...Read more