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Does Inbreeding In Families Cause Hemophilia To Develop
Not usually: Despite emphasis on hemophilia and royal families, rasputin's influence depended on common relatives among english/russian royalty. The well-known hemophilias are x-linked, passed through normal women with 2 xs to men with one. Inbreeding increases chances for matching up of rare, autosomal recessive mutations in spouses (e.g., cystic fibrosis, tay-sach's diseases). ...Read more
Queen Victoria: She was a new mutation, on the evidence. One of her X-chromosomes when transmitted to her male descendants resulted in their getting the disease. It wasn't just the British royal family; they were intermarried, and the Tsar's failure to produce a healthy heir prevented a constitutional monarchy run by reasonable people in Russia. Random events have grave consequences. ...Read more
It dosent: The bleeding is not the cause of this condition but the sign of the disorder. The person with hemophilia lacks some of the factors responsible for clotting. Thus any bleeding lasts for a longer time and is more profound as compared to a person with normal clotting mechanisms. ...Read more
It's not that simple: This isn't sickle cell anemia. A huge variety of different genetic mutations cause hemophilia A. The most common troublesome one is an inversion in intron 22. I'm sorry you had trouble finding an answer to this question, and perhaps you'll enjoy reading up on this complex but fascinating study. ...Read more
My sister has a son with hemophilia, but there is no family history other than that, is this just bad luck?
Yes: Some classes of antibiotics can prolong the prothrombin time, especially when taken with other medications. Your doctor should be aware of all of your medical conditions, all medications (including herbs and vitamins), and any subsequent symptoms. This can be dangerous and needs close monitoring and frequent lab work. ...Read more
Gene on X-chromosome: Hemophilia a is a hereditary bleeding disorder where there is a deficiency in clotting factor viii (factor viii is needed for blood clotting). It is inherited on the x-chromosome (sex-linked). Men only have 1 "x", so if their "x" is mutated, they will have the disease. Women have 2 "x's", so they can have 1 mutated "x" and 1 normal "x", and be a carrier of the disease, with mild or no symptoms. ...Read more
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