Top
30
Doctor insights on: Does Inbreeding In Families Cause Hemophilia To Develop

Share
1

1
Does inbreeding in families cause hemophilia to develop?

Does inbreeding in families cause hemophilia to develop?

Not usually: Despite emphasis on hemophilia and royal families, rasputin's influence depended on common relatives among english/russian royalty. The well-known hemophilias are x-linked, passed through normal women with 2 xs to men with one. Inbreeding increases chances for matching up of rare, autosomal recessive mutations in spouses (e.g., cystic fibrosis, tay-sach's diseases). ...Read more

Dr. Susumu Inoue
123 Doctors shared insights

Hemophilia (Definition)

A disorder in which ...Read more


2

2
What caused hemophilia in the British royal family?

Queen Victoria: She was a new mutation, on the evidence. One of her X-chromosomes when transmitted to her male descendants resulted in their getting the disease. It wasn't just the British royal family; they were intermarried, and the Tsar's failure to produce a healthy heir prevented a constitutional monarchy run by reasonable people in Russia. Random events have grave consequences. ...Read more

3

3
What are some organizations that can help a family cope with a child's hemophilia?

Hemophilia groups: The hemophilia websites I find most valuable (and accurate) belong to the national hemophilia foundation and world federation of hemophilia. ...Read more

4

4
My sister has a son with hemophilia, but there is no family history other than that, is this just bad luck?

Perhaps: Hemophilia a & b are x-linked recessive while c is usually autosomal recessive. So, it's possible that the mother was a carrier. However, about 1/3 of a & b cases are due to spontaneous mutation. ...Read more

5

5
What type of mutation causes hemophilia?

What type of mutation causes hemophilia?

Hemophilia: A mutation on the x chromosome that affects the blood clotting factors viii or ix. ...Read more

6

6
Can you tell me how bleeding cause hemophilia?

Can you tell me how bleeding cause hemophilia?

It dosent: The bleeding is not the cause of this condition but the sign of the disorder. The person with hemophilia lacks some of the factors responsible for clotting. Thus any bleeding lasts for a longer time and is more profound as compared to a person with normal clotting mechanisms. ...Read more

7

7
What is the amino acid substitution that causes hemophilia?

What is the amino acid substitution that causes hemophilia?

It's not that simple: This isn't sickle cell anemia. A huge variety of different genetic mutations cause hemophilia A. The most common troublesome one is an inversion in intron 22. I'm sorry you had trouble finding an answer to this question, and perhaps you'll enjoy reading up on this complex but fascinating study. ...Read more

8

8
What type of mutations that cause hemophilia a?

Gene on X-chromosome: Hemophilia a is a hereditary bleeding disorder where there is a deficiency in clotting factor viii (factor viii is needed for blood clotting). It is inherited on the x-chromosome (sex-linked). Men only have 1 "x", so if their "x" is mutated, they will have the disease. Women have 2 "x's", so they can have 1 mutated "x" and 1 normal "x", and be a carrier of the disease, with mild or no symptoms. ...Read more

9

9
What causes hemophilia?

Genetic defect: Hemophilia is a bleeding disorder due to abnormal gene for clotting factor viii (hemophilia a) or ix (hemophilia b) that is on the x-chromosome and men inherit the defect from their mothers. Women are carriers and are rarely affected. ...Read more

10

10
What gene causes hemophilia a, how is it inherited?

What gene causes hemophilia a, how is it inherited?

Gene for Factor VIII: Hemophilia a is a hereditary bleeding disorder where there is a deficiency in clotting factor viii (factor viii is needed for blood clotting). It is inherited on the x-chromosome (sex-linked). Men only have 1 "x", so if their "x" is mutated, they will have the disease. Women have 2 "x's", so they can have 1 mutated "x" and 1 normal "x", and be a carrier of the disease, with mild or no symptoms. ...Read more

11

11
Can excessive use of antibiotics cause prolonged pt in patients with hemophilia?

Can excessive use of antibiotics cause prolonged pt in patients with hemophilia?

Yes: Some classes of antibiotics can prolong the prothrombin time, especially when taken with other medications. Your doctor should be aware of all of your medical conditions, all medications (including herbs and vitamins), and any subsequent symptoms. This can be dangerous and needs close monitoring and frequent lab work. ...Read more

12

12
My son is 3 and has mild hemophilia A, I took him to the hospital 2 weeks about cause he bumped his head and he got a lump, my concern is that it's not going down what can I do?

My son is 3 and has mild hemophilia A, I took him to the hospital 2 weeks about cause he bumped his head and he got a lump, my concern is that it's not going down what can I do?

Patience: If he was evaluated and the only residual is the goose egg, you may just need to wait it out. When kids form a blood pocket after such an injury, it is located between the skull and a dense layer of scalp that has no regular blood supply. The bleeding stops itself by having a limited space to expand. It can time for the blood to break down and be absorbed. It will sometimes form a calcium deposit. ...Read more

13

13
Bleeding cystitis for 2 weeks. I am also a symptomatic carrier of Hemophilia A. CT scan was clear, but with blood in bladder. Can this cause problems?

Bleeding cystitis for 2 weeks. I am also a symptomatic carrier of Hemophilia A. CT scan was clear, but with blood in bladder. Can this cause problems?

Yes: For sure you must be under the care of a hematologist. Blood in the urine in your case sounds like it is due to hemophilia. If excessive you can become anemic. Follow the instructions of the doctor who is monitoring you. Best wishes. ...Read more

14

14
Does hemophilia only affect men?

It is more likely: Hemophilia mostly affects men. It is rare but not impossible for a female to have hemophilia. Hemophilia is a sex-linked recessive disorder: the trait is carried on the x chromosome which a female has two of and a male only has one. This means a female would have to inherit two copies of the hemophilia gene to have the disorder. A male only has to inherit one copy. ...Read more

16

16
How do you get tests for hemophilia?

How do you get tests for hemophilia?

Blood test: If suspected any doctor can order a blood test for hemophilia. There are two major types with deficiceny of different clotting factors, hemophilia a has deficincy of factor viii and hemophilia b of factor ix. Most hospital labs can do the testing on blood sample to make the diagnosis. ...Read more

17

17
Can you advise me on a child with hemophilia?

Can you advise me on a child with hemophilia?

How to help?: Children with hemophilia can lead long productive lives. It is essential that a pediatric hematologist is working closely with you and your child to develop a plan. Hemophilia can range from very mild to severe. If you have a more specific question, ask again. Otherwise, make sure you have a good relationship with a pediatric hematologist. They can point you toward good resources for help. ...Read more

18

18
When does hemophilia arise in a person's life?

At conception: Hemophilia is a genetic disorder due to defective gene (s) on x chromosome. ...Read more

19

19
Suffering from hemophilia. Young and want kids?

Daughters will be: Carriers. All of your daughters will be carriers of the disease and will transmit the disease to half their sons. ...Read more

21

21
How many years till hemophilia becomes less severe?

Therapy...: If you are asking when will therapy arrive that can make treating hemophilia easier, I would answer it is starting now. There are new factor replacements that have a longer half-life so that you don't have to dose as frequently (a major plus). Thinking big picture, I would say within 10 years we may have effective gene therapy to effectively cure or dramatically lessen the disease. ...Read more

22

22
Any website that I can use to get info on hemophilia?

Mayo Clinic: Try the site below:
http://www. Mayoclinic. Com/health/hemophilia/ds00218. ...Read more

23

23
Is there a cure for hemophilia?

No: Not yet, however, the disorder can be managed with injections of recombinant coagulation factors. ...Read more

24

24
Is there a cure for hemophilia?

Control is achieved: Not a cure, but control of bleeding episodes is achieved by periodic infusion of purified, genetically engineered, human factor viii, defects of which cause the most common form of hemophilia. ...Read more

25

25
Is hemophilia linked to patau syndrome?

Is hemophilia linked to patau syndrome?

No, not linked.: Hemophilia a and hemophilia b are caused by mutations in genes f8 and f9, respectively, on the x chromosome. Patau syndrome results from trisomy 13 (the presence of an extra #13 chromosome). ...Read more

26

26
Could hemophilia occur due to a mutation?

Could hemophilia occur due to a mutation?

Yes, a gene mutation: Hemophilia "a" is a hereditary bleeding disorder where there is a deficiency in clotting factor viii (factor viii is needed for blood clotting). It is inherited on the x-chromosome (sex-linked). Men only have 1 "x", so if their "x" is mutated, they will have the disease. Women have 2 "x's", so they can have 1 mutated "x" and 1 normal "x", and be a carrier of the disease, with mild or no symptoms. ...Read more

27

27
Is a normal lifespan possible with hemophilia?

For many, yes: For those who have mild or moderate hemophilia, the answer is yes. For patients with severe hemophilia, the most recent data suggests about a 10 year shorter life span. It is important to remember, however, that the people analyzed for this study were initially treated in a much earlier era. Most likely this difference will become smaller the better we get at treating and preventing serious bleeds. ...Read more

28

28
How can hemophilia affect the integumentary system?

Bruising...: Hemophilia is a defect in your blood's ability to clot properly. If this coagulation system is not working well, as happens in hemophilia, a person can have excessive bleeding and bruising. The skin itself (part of the integumentary system) is fine, but hemophilia can manifest itself as large bruises under the skin and excessive bleeding from a cut in the skin. ...Read more

29

29
Can you have facial piercings if you have hemophilia?

Can you have facial piercings if you have hemophilia?

Not recommended: Even the association of professional piercers recommends that you should not get a piercing if you have hemophilia. Bleeding is a risk associated w piercing even if you do not have hemophilia. ...Read more

30

30
If I have hemophilia, are bug bites a serious concern?

No: A hemophiliac's platelets work normally and they are quite sufficient to close these, the nicks you may get shaving, paper cuts, small knife cuts and in fact all but rather severe or repetitive injury, even when the hemophilia is severe. ...Read more