Doctor insights on:
Does Inbreeding In Families Cause Hemophilia To Develop
Not usually: Despite emphasis on hemophilia and royal families, rasputin's influence depended on common relatives among english/russian royalty. The well-known hemophilias are x-linked, passed through normal women with 2 xs to men with one. Inbreeding increases chances for matching up of rare, autosomal recessive mutations in spouses (e.g., cystic fibrosis, tay-sach's diseases). ...Read moreSee 1 more doctor answer
Is there a mutation with certain grandparents that can cause Asperger syndrome in their grandchildren?
See below: This question should be redirected to a pediatrician or medical genetics specialist. ...Read more
Can mutations in hla genes cause people to be predisposed to possibly developing an autoimmune condition?
Yes: Hla controls the immune system and mutations in hla and other genes in the same area may predispose to autoimmune disorders, especially complement deficiency. ...Read more
Genetica: This is certainly a dilemma faced by prospective parents every day. Those decisions are based on religious beliefs, what the genetic abnormality is and what the long and short term prognosis is. When one gets this kind of diagnosis a consultation with a certified genetics counselor is always recommended so that an educated decision can be made. ...Read moreSee 2 more doctor answers
Can grandparents carry a mutation to cause Asperger syndrome in grandchildren, skipping a generation?
Not that simple: For the most part what are inherited are genes coding for (snp)single nucleotide polymorphisims-different forms of enzymes that do not digest certain proteins. It is possible to be the contributor of (at most 1/4 total)genes that might contribute to certain symptom patterns. ...Read more
What genetic diseases most commonly occur in a child born from incest (between sibs or between parent & child)?
Varies considerably: The issue is like playing russian roulette. All of us carry recessive genes in our dna that do not express disease because they are balanced by normal genes. Things like cystic fibrosis are carried by 1/20, sickle cell 1/12. All of us carry an estimated 4 defects. Parent child/sib-sib pairings all may have a normal outcome or a bad outcome for any pregnancy. ...Read more
GENETIC: There is thought to be a familial component. It usually inherited as autosomal dominant. ...Read more
Does my child have to inherit the same exact mutation from both parents in order to develop cystic fibrosis?
Lots!: Generally, if you have fewer or more genes or chromosomes than you're supposed to have, intelligence may well be affected. Other genetic/metabolic diseases can damage the brain because of the toxic build up of by products from dysfunctional metabolism which the body may have difficulty disposing of. ...Read more
Why do some people develop autoimmune diseases/disorders after viral exposures, while some people do not? Could hla gene mutations be responsible?
Yes! To both!!: Both may be autoimmune diseases and frequently are hereditary! Both are very easily diagnosed by lab tests! See your physician if you think you have either of these illnesses! ...Read more
Homework project?: Timing death's unpredictable. Duchenne's, xeroderma pigmentosm, ehlers-danlos iv, tuberous sclerosis, mild recessive polycystic kidney, canavan's, many sicklers, krabbe's & other leukodystrophies, moderate gaucher's, hunter's, hurler's, ataxia-telangiectasia & other cerebellar degenerations, bloom's; very-common schizophrenia kills indirectly (suicide, accidents) and has a strong genetic component. ...Read more
Genetic hearing loss: Yes, a genetic mutation in mitochondrial RNA has been shown to predispose individuals to hearing and balance problems when they receive amino glycoside antibiotics. This can happen even at low doses typically acknowledged to minimize the risk of toxicity. At high doses, however, amino glycosides can exhibit toxicity in the ear even in individuals without this mutation. ...Read moreSee 1 more doctor answer
Proper care needed: As long as they are under proper medical attention there should be no problem. ...Read more
Any research on why some people get guillain-barre syndrome , when most don't? Does gbs tend to occur more in families with migraines/epilepsy?
Probably autoimmune: Preceding infection, such as flu, seems to trigger the event. The only variant with genetic predisposition is acute motor axonal neuropathy, in japan and china. Antibodies to gangliosides play a role. It is not more prevalent in families with migraines or epilepsy. ...Read moreSee 1 more doctor answer
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