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Doctor insights on: Does History Of Icp Cause Intrahepatic Cholestasis Of Pregnancy

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Could I have icp (intrahepatic cholestasis of pregnancy)? What are the risks?

Could I have icp (intrahepatic cholestasis of pregnancy)? What are the risks?

Icp causes itching: I have only had one patient with icp in 27 years of practicing obstetrics. Diagnosis is made by elevated bile salts (detectable by lab test) and the treatment is cholestyramine. Pregnancy outcome should be unaffected by the condition. So icp is rare and makes you miserable, but should not affect your baby. One case however hardly makes me an expert so second opinions welcome. ...Read more

Dr. Jeffrey Stevens
4 doctors shared insights

Pregnancy (Definition)

When your due date arrives, you will be more than ready to have your baby! Most women deliver the baby somewhere between 37 and 42 weeks. According to the American College of Obstetricians and Gynecologists, only 5% of babies arrive on the exact due date. Approximately 7% of babies are not delivered by 42 weeks, and when that happens, it is referred to ...Read more


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What is the result of liver function tests in intrahepatic cholestasis of pregnancy?

Cholestasis: You could elevated bilirrubin and alkaline phosphatase predominantly. Others sucn as transaminases can be elevated too. They will all normalize upon delivery. ...Read more

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What risks are associated with hemangioma of the liver during pregnancy?

What risks are associated with hemangioma of the liver during pregnancy?

Probably none: Unlike hepatic adenomas, the risk of pregnany related increase in size and associated bleeding is minimal to none. ...Read more

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How long does pruritus associated with intrahepatic cholestasis of pregnancy last?

Until pregnancy ends: Cholestasis of pregnancy is a considition which generally occurs in the 3rd trimester and is characterized by intense pruritis without rash and increase serum levels of free bile acids. The condition lasts until the pregnancy ends. The pruritis sometimes can be controlled with medications, such as ursodiol. ...Read more

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Is intrahepatic cholestasis of pregnancy painful?

Is intrahepatic cholestasis of pregnancy painful?

NO: Cholestasis of pregnancy does not generally cause pain. The most common symptoms is pruritis (itching). It almost always starts with itching on the palms of the hands and soles of the feet, and it is first noticed at night. The itching spreads to other parts of the body over time. Treatment with ursodiol (bile salts) can improve symptoms. Consultation with a high risk OB is recommended. ...Read more

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What is the possible cause of high sgpt/sgot with no signs of jaundice or any sickness?

What is the possible cause of high sgpt/sgot with no signs of jaundice or any sickness?

Sot and sgpt shows c: Look for causes of obst jaundice or hemolysis first. Cell death isindicated by high SGOT sgpt. Get a bilirubin, alk phos and an ultrasoundfor starters along with a hepatitis profile. ...Read more

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How long does abdominal pain associated with intrahepatic cholestasis of pregnancy last?

How long does abdominal pain associated with intrahepatic cholestasis of pregnancy last?

24-48 hrs: Usually all symptoms of intrahepatic cholestasis of pregnancy resolve within 24-48 hrs after delivery, in rare cases sx may continue to up to one week after and may signify retained placenta. But if you have this condition pregnancy needs to be monitored by obgyn very closely as poor outcomes for the baby are not uncommon if not monitored. ...Read more

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Can cholestasis of pregnancy cause long term inflammation to common bile duct? Can hormones affect liver enzymes and itching during period?

Can cholestasis of pregnancy cause long term inflammation to common bile duct?  Can hormones affect liver enzymes and itching during period?

Possibly: the itching is from the cholestasis as it causes the bike to go up and this causes the itching. The inflammation can persist, but can also resolve. External hormone use has to be processed by liver first, so they can place "pressure" on the liver, as can Tylenol, (acetaminophen) and any other medications typically. ...Read more

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What can cause sudden elevation of liver levels in a patient with biliary cirrhosis on meds?

What can cause sudden elevation of liver levels in a patient with biliary cirrhosis on meds?

PBC Elevated LFT's: Primary biliary cirrhosis (pbc) itself is a terminal cirrhotic state of liver, requiring liver transplant. There is not much ast & alt enzymes left in liver to go up. Certain insults, can expedite liver damage, by elevated lft's: medicines metabolized by liver, alcohol, an obstruction in porta hepatis, ? Malignancy, need to be considered. ...Read more

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What are the long-term effects of cholestatic jaundice?

What are the long-term effects of cholestatic jaundice?

Several: They depend on cause and age of patient. In preterm infants, it is frequently from prolonged use of TPN and late start of feeds. Majority resolve. In some cases it can cause gall bladder sludge, gall stones or inflammation/infection of the plumbing system of the liver (cholangitis). In extreme cases, these patients can develop cirrhosis and chronic liver failure and may need liver transplant. ...Read more

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What are the risks of pulmonary hypertension during pregnancy?

What are the risks of pulmonary hypertension during pregnancy?

Big: Very complex condition, if taking era drugs are toxic. Other no, will depend on the pressures, fc, etc.Talk with your ph expert soon or ger a ph center appt. ...Read more

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Have you noticed any links between the use of isotretinoin and the development of various liver/ biliary system disorders (i.E.: hepatic cholestasis)?

Have you noticed any links between the use of isotretinoin and the development of various liver/ biliary system disorders (i.E.: hepatic cholestasis)?

NO: Isotretinoin is one of the most researched medications on the planet. Roche , the initial company that made the medication, did tons of studies on this med. There have been reported cases of depression, ulcerative colitis, crohn's disease coming on while someone is on isotretinoin. Some of these cases were won in courts of law. Later studies suggested that these were probably coincidence. ...Read more

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MRCP "Persistent mild dilation of the central intrahepatic duct. There are areas of mild narrowing & irregularity of the intrahepatic ducts & proximal common duct. No dilation of common bile duct. Gallbladder sludge is present." What causes this?

MRCP "Persistent mild dilation of the central intrahepatic duct. There are areas of mild narrowing & irregularity of the intrahepatic ducts & proximal common duct. No dilation of common bile duct. Gallbladder sludge is present." What causes this?

Nonspecific: I believe that the ductal findings are nonspecific. Sludge in the gall bladder can cause abdominal distress and indigestion. A gastroenterologist would sit down with the radiologist and review the images and decide whether more imaging studies like an MRI or liver biopsy are advisable depending upon your symptoms or lack of symptoms. ...Read more

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What causes enlargement of the liver in someone with pre-eclampsia?

What causes enlargement of the liver in someone with pre-eclampsia?

Not fully understood: Preeclampsia and eclampsia are not fully understood. Neither are fully understood laboratory changes associated with it like changes in liver enzyme levels or platelet numbers nor why sometimes the liver is enlarged or the kidneys show signs of damage and at other times they don't. Effective treatment in almost all cases is removal of the placenta, with sooner or later recovery of the patient. ...Read more

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What are the early signs of hepatic encephalopothy?

What are the early signs of hepatic encephalopothy?

Confusion: It can vary in how it manifests which can be mild confusion to coma. ...Read more

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In cirrhosis does the presence of ascites always indicate decompensation and is this considered a serious complication and stage of the disease?

In cirrhosis does the presence of ascites always indicate decompensation and is this considered a serious complication and stage of the disease?

It is concerning: Ascites- buildup of fluid in the abdominal cavity- can be a sign of serious decompensation in the liver function. This is usually seen in the later stages of liver failure. If this is seen you should let your doctor know right away. This is associated with decreased survival. However if the cause of the liver damage is found early-& treated this can delay progression. Cirrhosis can't be undone. ...Read more

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Are the only causes of jaundice liver related?

Are the only causes of jaundice liver related?

Mostly: Severe hemolytic anemia overloads capacity of liver to process hemoglobin from ruptured blood cells. Disease of gall bladder, bile duct, pancreas can block the bile flow. Gilbert's disease can cause jaundice when liver function is otherwise normal. There are others. ...Read more

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Dr. Katherine Kohari
38 doctors shared insights

Cholestasis Of Pregnancy (Definition)

A condition where the flow of bile, a digestive fluid produced by the liver, slows or stops. As a result, the bile enters the bloodstream and causes "intense itching" in the mother on the palms and ...Read more


Dr. Sewa Legha
79 doctors shared insights

Cholestasis (Definition)

When the flow of bile (chole) is held back (stasis). It can be from the liver cells not moving it (often from medications), or from the biliary tree being plugged by ...Read more