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Doctor insights on: Does Exposure To Sulfasalazine Cause Congenital Abnormalities

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What environmental chemicals known to cause cancer and birth defects?

What environmental chemicals known to cause cancer and birth defects?

Too many to list: A large number of environmental chemicals are carcinogenic, e.g., arsenic, benzene, pcb, aflatoxin, radon, alcohol and radioactive isotopes. Mercury, acutane, alcohol, lead etc cause birth defects. ...Read more

Dr. Richard Roberts
63 doctors shared insights

Congenital Malformation (Definition)

Congenital malformation is aphysical defect present in a baby at birth that can involve many different parts of the body, including the brain, heart, lungs, liver, bones, and intestinal tract. Congenital malformation can be genetic, it can result from exposure of the fetus to a malforming agent (such as alcohol), or it can ...Read more


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What cardiac diseases or conditions that can be caused by Anemia ? How long does it take for anemia to affect the heart ?

What cardiac diseases or conditions that can be caused by Anemia ? How long does it take for anemia to affect the heart ?

Unusual to affect he: Anemia rarely causes any heart damage although the Heart has to work harder in patients who have more than mild Anemia and that too if they have chronic Anemia like in patients with Sickle cell disease or other hemolytic anemias for which there is no cure. Most times this does not mean that the heart is damaged or diseased due to anemia. ...Read more

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Does congenital heart defects lead to growth changes?

Does congenital heart defects lead to growth changes?

They can/some don't: Congenital heart defects include a number of conditions that vary greatly in their impact on final growth. The more severe the defect, the more likely it will require multiple surgeries and impair the bodies strength & growth. The cyanotic or blue baby group of defects are more likely to do this.Some defects, like the common small VSD self correct & seldom if ever alter the patients life. ...Read more

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Does azathioprine cause cause birth defects in men?

Does azathioprine cause cause birth defects in men?

Data presented on : This site http://www.Ncbi.Nlm.Nih.Gov/m/pubmed/15023170/ suggest an ?ed risk of congenital abnormalities. Since affected progeny had the same disorders as their fathers, a causal association with an immunosuppressant could not be proven. Please consult your wife's ob-gyn & request a pre-pregnancy visit with a prenatal genetic counselor to assist you in decision-making. ...Read more

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How does Rheumatic Heart Disease lead to rhythm issues? Which ones are common with RHD? How does RHD present on echocardiogram?

How does Rheumatic Heart Disease lead to rhythm issues? Which ones are common with RHD? How does RHD present on echocardiogram?

Atrial arrhythmia : Rheumatic heart disease results in one or multiple valves becoming stenotic or obstructed thereby leading to increased intracardiac pressures in the upstream chambers. That in turn causes dilatation of the atria And electrical instability (arrhythmia). Valve morphology on echo would be highly suggestive of RHD as it has a tell tale pattern well described. Treat valve disease to heal ...Read more

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Can congenital heart defects or certain drugs result in increased cardiac output? What else causes it? Mine is 7.2lmin squared.

Can congenital heart defects or certain drugs result in increased cardiac output? What else causes it? Mine is 7.2lmin squared.

CO = HR x SV: Cardiac output (co) is the volume of blood pumped per minute, and related to heart rate (hr) and stroke volume (sv) (volume per heart beat). It can be affected by many bodily activities. An increase in either hr or sv can result in inceased co. So any drug that increases hr (caffeine, etc) can result in incresed co. Certain congenital heart defects (such as septal defects) can alter co. ...Read more

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Could exposure to formaldehyde cause birth defects?

Could exposure to formaldehyde cause birth defects?

No: According to the national institute of health and our government who reviewed all the literature. The answer was there is little evidence of reproductive or developmental toxicity. ...Read more

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How does hypersensitivity due to multiple sclerosis be reduced?

How does hypersensitivity due to multiple sclerosis be reduced?

Numerous ways: First, make certain that modern potent meds are being used, not the older self-injectables. Supplement with vitamin d. The sensitivity may respond to gabapentin, lyrica, (pregabalin) cymbalta, or a series of patches, even localized blocks. Various rehab approaches including acupuncture may work well. ...Read more

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Does radiation poisoning cause birth defects?

Does radiation poisoning cause birth defects?

Yes: It depends on the amount of exposure and the timing in the pregnancy. Early on in the pregnancy, radiation poisoning will likely lead to a miscarriage. Later on in the pregnancy, radiation poisoning can lead to death or growth disturbances or congenital malformations. ...Read more

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What conditions or changes could cause marijuana to have adverse effects?

What conditions or changes could cause marijuana to have adverse effects?

Age, strain,genetics: Marijuana is hazardous for young people- regular users will have lower iq til about age 17. Some people become very anxious from it- this is related to your genetics/constitution but can also be influenced by the strain as diff. Strains have varying ratios of thc, cbd etc, thus some are more calming ; agitating. Like all medicines, what helps some can harm others ; it is not for everybody! ...Read more

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How does genetic diseases cause a person to be more susceptible to cancer?

How does genetic diseases cause a person to be more susceptible to cancer?

Profound question!: Some (not all) inherited traits affect genes that have to do with the control of cell division, cell growth, and programmed cell death. Others regulate the repair of dna damage that occasionally happens when cells divide. Those messed up genes can result in cancer development. Great question, thanks. ...Read more

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Does hashimoto's run in families? And does it have potential to cause pernicious anemia?

Does hashimoto's run in families? And does it have potential to cause pernicious anemia?

Yes! To both!!: Both may be autoimmune diseases and frequently are hereditary! Both are very easily diagnosed by lab tests! See your physician if you think you have either of these illnesses! ...Read more

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Which stage in human fertilisation/conception/pregnancy period does susceptibility to environmental factors that may contribute/cause defects start?

Which stage in human fertilisation/conception/pregnancy period does susceptibility to environmental factors that may contribute/cause defects start?

Before conception: The woman is born with all the eggs she will ever have and they mature over her lifetime until either released or lost.All exposure to chemicals/radiation/illnesses during a woman's life impact the egg quality.Once released to conception, the environmental influences on outcome are continuous.Some are time specific (thalidomide-5-7 wks) some are continuous (alcohol). ...Read more

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Can autoimmune cause a higher succeptibility to infection?

Sometimes: Some autoimmune diseases carry an increased risk of infection, most others do not. ...Read more

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What is a heart mumur? Can it be detected during an ultrasound? What causes it? can zofran (ondansetron) be the cause? If no family Hx of heart diseases or defects?

What is a heart mumur? Can it be detected during an ultrasound? What causes it? can zofran (ondansetron) be the cause? If no family Hx of heart diseases or defects?

Heart murmur: Heart murmur is simply a noise heard by an examiner originating in the heart. The common denominator among all causes is turbulent blood flow. This may be normal (children, pregnancy), physiologic (anemia, fever, XS thyroid) or pathologic (valve or architecture abnormality). Zofran (ondansetron) is not a cause. Echocardiography (heart ultrasound) is the test of choice to evaluate. ...Read more

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Can genome sequencing help to reveal the cause of an intellectual disability? How can an 'unknown cause' of it be eventually clarified?

Can genome sequencing help to reveal the cause of an intellectual disability? How can an 'unknown cause' of it be eventually clarified?

Yes: Causes of Intellectual Disability are: Chromosomal-30%, CNS malformations-15%, Congenital syndromes-5%, Metabolic-5%, Acquired-15%, Unknown-25-38%. Genetic testing revealed cause in 50% of these cases. Notably numerous other tests are important to diagnosis as well. Recent advances in cytogenetic & molecular genetic testing will lead to improved diagnosis & lower the % of unknowns in future. ...Read more

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A dr. said thyroid abnormalities can cause adults over 35 to grow taller. Which ones cause that? Hypothyroidism? Do any other rare genetic disorders?

A dr. said thyroid abnormalities can cause adults over 35 to grow taller. Which ones cause that? Hypothyroidism? Do any other rare genetic disorders?

Myth: Perhaps you are citing that PHD in electrical engineering that posts health claims on the web. You do not grow taller after your growth centers (late teens to early 20's). ...Read more

Dr. Nikolaos Zacharias
841 doctors shared insights

Congenital Abnormalities (Definition)

Abnormalites that are present at birth. Also known as birth defects. For example- cleft palate is a congenital abnormalities. Another example congenital heart disease is the presence of a ...Read more


Dr. Nikolaos Zacharias
480 doctors shared insights

Birth Defects (Definition)

A physical or biochemical abnormality that is present at birth- it may be inherited or ...Read more