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Doctor insights on: Does Cd19 Lambda 702 And Cd19 Kappa 132 Indicate An Abnormal Kappa Lambda Ratio

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How much increase in kappa lambda ratio Wud mean worrisome?

How much increase in kappa lambda ratio Wud mean worrisome?

Kappa/lambda: Hi, the normal Kappa/lambda is approximately 0.26 to 1.65. this ratio has to be interpreted along with Serum electrophoresis and also the free light chain values (kappa and lambda), if the free chain is elevated and the ratio is elevated then that could be due to plasma cell disorders like multiple Myeloma or Primary Amyloidosis if the symptoms present. Having said that it's not easy to draw ...Read more

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Can you get all amyloidosis if you have kappa rather than lambda light chains? I also have a kappa lambda ratio of 175

Can you get all amyloidosis if you have kappa rather than lambda light chains?  I also have a kappa lambda ratio of 175

Yes: Listen, Jane. I'm worried about you. You're already on cyclophosphamide and dexamethasone -- extremely potent medications -- yet you list no illness for which they are indicated. It's not for your thyroid cancer. You have a duty to find out exactly what is happening with you, including getting a 2nd opinion from a physician who's explain clearly. Amyloid is confusing; be proactive. ...Read more

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My haematologist says my kappa lambda ratio is seriously skewed. Kappa light chains @580 paraproteins 30. Does this imply a poor outcome?

My haematologist  says my kappa lambda ratio is  seriously skewed. Kappa light chains @580  paraproteins 30. Does this imply  a poor outcome?

Bad ratio: I am surprised you do not ask your oncologist questions about your outcome. Did you not ask? If you did, did you not get a response that you understood. You oncologist (o) knows your case best of all. Give your o a call and get your answer from the physician who knows you best of all. ...Read more

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Kappa Lambda ratio u 1.92(L) Free kappa LT chains ur 32.10 (H) Free Lambda LT chains ur 16.70 (H) 24 hour urine What does this mean?

Kappa Lambda ratio u 1.92(L) Free kappa LT chains ur 32.10 (H) Free Lambda LT chains ur 16.70 (H)  24 hour urine  What does this mean?

Nothing: In isolation, these mean nothing at all. If only one of the chains is being excreted, I'd worry about plasma cell myeloma. If you're leaking protein in your urine because of your diabetes, this is more concerning than light chain ratios. ...Read more

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I've just found out that 3 tests show low kappa/lambda ratio, with lambda light chain levels increased. Do these results mean a thing without m protein?

I've just found out that 3 tests show low kappa/lambda ratio, with lambda light chain levels increased. Do these results mean a thing without m protein?

Check with your doc: Kappa and lambda are parts of immunoglobulins which are proteins certain white blood cells make to fight infections. These are referred to as polyclonal since they come from different cells. Some blood disorders can produce lots of m (monoclonal) kappas or lambdas that come from a single, usually malignant cell. Ask your doctor who ordered the lab test to help interpret your specific results. ...Read more

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Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?

Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?

Clinical context : The use of light chains is limited in diseases other than monoclonal gammopathies, such as myeloma or amyloidosis. If this is the context that yours got checked the results do not suggest such a condition. With no gammopathy suggested by results the question regarding clonality has no grounds. As any other test, trending the results would help in integrating it in a meaningful clinical context. ...Read more

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Hemoglobin 8.4, kft, anemia profile, protein electroph, iron, b12, folate, (folic acid) m protein - all normal. Kappa lambda ratio 2.96 - means ?

Hemoglobin 8.4, kft, anemia profile, protein electroph, iron, b12, folate, (folic acid) m protein - all normal. Kappa lambda ratio 2.96 - means ?

?Find cause for Anem: You have anemia for which your doctors should find a cause. This requires doing a variety of tests which a good physician or a hematologist(blood specialist) can do. Unless already done, you need an examination of your bone marrow and more tests till we find the cause of your anemia. The light chains may be hinting at a possible cause which can be checked further with a bone marrow examination. ...Read more

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Kappa 132.97 lambda 60.97 ratio serum 2.18 what does this mean?

Kappa etc: hello ~ I dont know there's not enough information. I would make huge diagnostic mistakes if I assumed any of the absent information and you would not be pleased with anything except 100% accuracy. thanks ...Read more

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I had a IgA Heavy Light Chains (HLC), S test done. Ig K/L HLC Ratio, IgA Kappa, S and IgA Lambda, S were in normal range. What does this test mean?

I had a IgA Heavy Light Chains (HLC), S test done.  Ig K/L HLC Ratio, IgA Kappa, S and IgA Lambda, S were in normal range.  What does this test mean?

Nothing: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, The tests you mentioned have a high number of false positives and false negatives and are or questionable value. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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Sed rate of 28 kappa.67 lambda 3.17 ratio 1.47...What is going on?

Sed rate of 28 kappa.67 lambda 3.17 ratio 1.47...What is going on?

I suspect nothing: As far as this pathologist is concerned, a sed rate of 28 is fine especially for an adult female like yourself. It's worthless unless very high, and even then only to confirm systemic inflammation. The new work on intact and fragmented antibodies shows a huge variability in the ratios of kappa and lambda and i would draw no conclusions whatever. You're a person, not numbers. How do you feel? ...Read more