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Doctor insights on: Does An Elevated Ca 125 Level Always Indicate That Ovarian Cancer Is Present

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Does an elevated ca 125 level always indicate that ovarian cancer is present?

Does an elevated ca 125 level always indicate that ovarian cancer is present?

No: Ca-125 may also be elevated in other cancers (i.e. Endometrial, fallopian tube, lung, breast and gastrointestinal cancers.) it can also be elevated with endometriosis or any inflammatory condition in the abdominal area. ...Read more

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Dr. Barry Rosen
4,224 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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My ca125 levels are slightly elevated and there is a solid mass on my ovary, should I be concerened that it is ovarian cancer?

My ca125 levels are slightly elevated and there is a solid mass on my ovary, should I be concerened that it is ovarian cancer?

Depends: Ask your gyn. A solid mass is concerning, but your age, menopausal status, and the ultrasound characteristics are important as well. Elevated ca-125 suggests ovarian cancer, but may be somewhat elevated in many benign conditions, as well, including endometriosis. All of this needs a discussion with your gyn and a possible referral to a gyn oncologist - who are the real experts in this area. ...Read more

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I have ovarian cysts on my both ovaries. still I am twenty. My CA 125 count is 478 . is it a ovarian cancer?

Unlikely but needs m: Any mass(even a cyst) if it is growing and gets to be over 5-6 CM has to be suspect for ovarian cancer. So you need a good gynecologist who can examine and check your ovaries periodically(like every 3 months). CA 125 can be high even in benign conditions unless it is rising rapidly and gets up to be.500 units. This should be checked periodically at 3 month intervals along with the Ultrrasound . ...Read more

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How accurate is ca125 test for ovarian cancer?

How accurate is ca125 test for ovarian cancer?

99% when cancer: Ca-125 is 99% accurate if an ovarian cyst or tumor happens to be cancer. The problem with this blood test is that it is very inaccurate when there is no cancer (called a false positive), sometimes up to 45%. This is why ob/gyns do not use this test as a screening test, or at patient request. ...Read more

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How reliable is the ca125 test for ovarian cancer?

How reliable is the ca125 test for ovarian cancer?

CA 125: Ca 125 is not a reliable test to look for ovarian cancer. It is used in follow up of a woman with ovarian cancer or similar cancers. ...Read more

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Can a woman have a normal ca125 blood test and still have ovarian cancer?

Can a woman have a normal ca125 blood test and still have ovarian cancer?

Ovarian cancer: Yes. Only 85% of ovarian cancers have an elevated ca 12 at presentation. Therefore, 15 of every 100 women with a diagnosis of ovarian cancer have a ca 125 within the normal range. Ca 125 is not a diagnostic test. But is used to follow the progress of chemotherapy. ...Read more

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In stage 4 ovarian cancer, what does it usually mean if your ca-125 goes from 600 to 222 then back up to 350?

Some response: If therapies are changed we look at the ca125 levels to guide the choice of chemotherapy. This would be compatible with a temporary response to type of therapy. ...Read more

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How precise is the ca-125 test for ovarian cancer?

Other conditions too: Ca25 test can be positive in many conditions pregnancy endometriosis uterine fibroids pancreatitis liver disease normal menstruation other malignancies like lung, breast.Pacreas and GI tract cysts of the ovaries so here you have it it is not a specific test for ovarian cancer, thogh it may be positive as well. ...Read more

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How accurate is the ca-125 test for an ovarian cancer?

Not very.: Ca 125 is touted as a screening tool for ov ca but is elevated in only 50% of those with early stage disease. Approx 1% of normals have a high ca 125. Since ovarian cancer is relatively uncommon, the ability of a positive test to predict ca is about 3%. There is general consensus that ca 125 is not a good screening tool for average risk females. Consider ca 125 for those with high risk. ...Read more

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Is it possible to have ovarian cancer and have a normal ca 125 blood test?

Is it possible to have ovarian cancer and have a normal ca 125 blood test?

Yes.: Ca125 can vary from person to person and can change under various circumstances not related to cancer. It is more useful as a way to track disease progression or treatment success. ...Read more

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Dr. Gurmukh Singh
481 doctors shared insights

Ovarian Cancer (Definition)

It is a cancer which arises from the ovary. This cancer is typically silent, producing little or no symptoms till it spreads, first into the pelvic area and later into the peritoneal cavity leading to fluid accumulation(ascites) which is often the first symptom. Despite its late presentation, there is a reasonable treatment for it, with some long term survivors even ...Read more


Dr. Milroy Samuel
125 doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more