Doctor insights on:
Does Alpha Thalassemia Causes Leukemia
No: Alpha and beta thalassemia have not been reported to cause leukemia, which is cancer of the white blood cells. There is a study of beta thal. Major & intermedia patients in iran, where researchers found 5 leukemia cases in about 4, 600 patients. That is a higher rate of leukemia than in the general population there, but details were unavailable as to what other factors were present in the patients. ...Read moreSee 1 more doctor answer
Leukemia is a malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more
I had leukaemia (ALL) 11 years ago and now have been diagnosed with alpha-thalassemia - are the two linked? I'm white British so not typical for this
Probably not: Alpha thalassemia probably doesn't cause pvc's (premature ventricular beats, a type of extra heartbeat). However, some thalassemia patients have magnesium deficiency, which can make pvc's more likely to occur. Patients who get transfusions off and on may be drinking lots of coffee, using caffeine or phenols in coffee to decrease iron absorption, to hold off iron overload. Caffeine can cause pvc's. ...Read moreSee 1 more doctor answer
None to severe/fatal: Alpha thalassemia signs and symptoms: silent carriers have no signs/symptoms (and live a normal life); Alpha trait has mild anemia (and generally live a normal life); HGB h (moderate) may have weakness, pallor, less growth, and need some transfusions; bart's disease (severe) is usually fatal before birth. ...Read moreSee 1 more doctor answer
4 alpha genes...: It is a bit complicated given that there are 4 Alpha chain genes and Alpha thalassemia can involve mutations in one, two (in two different ways) or three genes (mutations in four genes is usually not compatible with life). For excellent website, see: http://www.Stjude.Org/stjude/v/index.Jsp?Vgnextoid=d966885309c6f110vgnvcm1000001e0215acrcrd. ...Read moreSee 1 more doctor answer
Conventional: As scientists investigated hemoglobin, the complicated compound in red blood cells that carries oxygen, they learned that it was made up of 5 parts; 4 of these are 2 copies each of 2 different proteins. They named these Alpha chains and beta chains. If you inherit a condition where the Alpha chains are produced in smaller amounts than normal, you have Alpha thalassemia. ...Read moreSee 1 more doctor answer
Not quite: People normally have 4 Alpha globulin genes. A mutation in 1, 2, 3, or all 4 genes leads to the 4 levels of Alpha thalassemia. The genetics of the disorder is not all-or-none, not dominant-recessive. Instead, the more mutations, the worse the disease. One mutation = silent carrier (no symptoms), 2 muta. = Alpha trait (mild symptoms), 3 muta. = HGB h (moderate symptoms), 4 muta. = bart's (deaths). ...Read moreSee 1 more doctor answer
None to severe/fatal: Alpha thalassemia signs and symptoms: silent carriers have no signs/symptoms; Alpha trait has mild anemia; HGB h (moderate) may have weakness, pallor, less growth, and need some transfusions; bart's disease (severe) is usually fatal before birth. ...Read moreSee 1 more doctor answer
Inherited defect: Our regular hemoglobin is composed of Alpha and beta chains that come together to form working hemaglobin. Alpha thalassemia trait occurs when a person inherits a defective Alpha chain gene from one parent & a normal Alpha chain gene from the other. This causes some reduction in Alpha chain production with resulting mild anemia. ...Read more
Hemoglobin problem: Alpha thal is caused by mutations that effect the production of a part of the hemoglobin molecule (Alpha chain). There are 4 genes involved in this production. Mutations can occur in 1 to 4 of these genes. The disease is more problematic the more genes are mutated. This disease is inherited from parents. ...Read more
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