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Doctor insights on: Does A Negative Parr Result Rule Out Lymphoma

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Does a negative parr result rule out lymphoma?

Does a negative parr result rule out lymphoma?

No?: Polymerase chain reaction (pcr) for antigen receptor rearrangements (parr) is not a test i would necessarily consider in initial lymphoma diagnosis. Lymphoma is diagnosed (ideally) by an excisional (not just needle) biopsy and/or bone marrow biopsy. There are many additional tests including molecular (eg, pcr) tests that can be used to further subclassify diagnosis. ...Read more

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Dr. Michael Thompson
1,746 doctors shared insights

Lymphoma (Definition)

A malignancy developing in the lymphocytes of lymph glands. They present as an enlarging node that continues to grow and then ...Read more


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Would a negative ANA rule out lymphoma? Does lymphoma cause a positive ANA test result?

Would a negative ANA rule out lymphoma? Does lymphoma cause a positive ANA test result?

It does not: At your age, if you have lymphoma it's probably Hodgkin's. ANA really has nothing to do with malignant lymphoma. If you're worried about big lymph nodest, trust me -- lymphoma nodes are obviously very abnormal. Best wishes, and I hope you'll always stay actively involved with your health. ...Read more

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Can 2 biopsies done at same time rule out cutaneous t-cell lymphoma completely? If symptoms point to ctcl but biopsy was neg when should we re-biopsy?

Can 2 biopsies done at same time rule out cutaneous t-cell lymphoma completely? If symptoms point to ctcl but biopsy was neg when should we re-biopsy?

Not Completely: The average number of biopsies to completely diagnose CTCL is about 6. That said, if the type of CTCL is the common type, mycosis fungoides(MF), and not mimics of MF, then 1 or 2 biopsies could be diagnostic especially if typical patches, plaques of CTCL. If the latter, ancillary tests including molecular clonality T cell test are crucial for diagnosis excluding mimics. Rebiopsy in about 3 mos. ...Read more

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Diagnosis. B.Cell non hodgkin, s lymphoma favor burkitt, s lymphoma. This us the result of biopsy taken during appendicectomy. D20 positive and tdt neg?

Diagnosis. B.Cell non hodgkin, s lymphoma favor burkitt, s lymphoma. This us the result of biopsy taken during appendicectomy. D20 positive and tdt neg?

CD20 is a B-Cell: Marker hence the assignment of a b-cell nhl. Tdt is an immunohistochemical stain used to classify blood cells. Burkitt's is a very aggressive process -- get started on a plan with a hematologist straight away. ...Read more

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Lymph node removed n biopsy result states "no definite evidence of lymphoma. Advised follow up to rule ojr hodgkins disease.Is it a problem?

Lymph node removed n biopsy result states "no definite evidence of lymphoma. Advised follow up to rule ojr hodgkins disease.Is it a problem?

May be: The pathology report has contradictory information. You should discuss it with your doctor to consider having a hematopathologist review the biopsy slides for a second opinion. ...Read more

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If tested for lymphoma previously and came up negative before due to having an aunt pass because of it could you still have a chance to develop it?

If tested for lymphoma previously and came up negative before due to having an aunt pass because of it could you still have a chance to develop it?

Why do you ask?: You're 23 years old. Your risk for lymphoma is very low; the highest risk is Hodgkin's which is usually curable nowadays. A person can develop lymphoma at any age, but it's not very likely. If you have fever, weight loss, or night sweats, look for some other case -- TB, endocarditis, other possible causes. ...Read more

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Please tell me, could my blood results mean lukiemia or lymphoma?

Please tell me, could my blood results mean lukiemia or lymphoma?

Hard to say...: Without knowing exactly what those results are, it is impossible to tell. Leukemia can be frequently diagnosed based on examination of the blood, lymphoma not so often. Please ask your physician to interpret the results of your blood tests for an adequate diagnosis. ...Read more

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Fnac report negative, but biopsy shows burkins lymphoma.Is it possible?Why?

Fnac report negative, but biopsy shows burkins lymphoma.Is it possible?Why?

Sampling error: Fine needle aspirate of lymph nodes are not ideal for ruling out abnormal findings. Especially, with lymphomas there may be areas within the ln that are not involved and sampling of these areas may be misleading. Excisional biopsy is the gold standard, as it allows for assessment of individual cells and architecture of lymph node and adequate tissue for specialty workup. ...Read more

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Can lymphoma be diagnosed with biopsy of lymphnodes? If so how long does it take to get results?

Yes: Biopsy of lymph nodes is a standard procedure to rule out lymphoma. Pathology reports usually come back to the physician within several days, but it can depend on the lab and the quality of the biopsy. One week is a reasonable expectation. ...Read more

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Is an ultra sound scan enough to rule out lymphoma?

Swollen Glands: I am sorry that your medical team is not teaching you that swollen glands are evidence of immune health not evidence of lymphoma. An active immune system is working round the clock to fight off infections that you cannot even feel or know about. Worrying about lymphoma is common but extremely unnecessary. Lymphoma has other symptoms not 'swollen glands'. An U/S is unnecessary and not diagnostic. ...Read more

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Biopsy done and report says"no definite evidence of lymphoma. Advised follow up to rule out hodgkins desease". Is it a problem?

Biopsy done and report says"no definite evidence of lymphoma. Advised follow up to rule out hodgkins desease". Is it a problem?

Maybe: What kind of biopsy was it? Most of the time a fine needle biopsy is performed but sometimes the entire lymph node needs to be removed to determine whether or not lymphoma could be a problem. Please follow up as instructed and i'll keep my fingers crossed! best wishes! ...Read more

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Have you done a neck biopsy to rule out lymphoma? How hare is it?

I have HAD a neck: Node biopsy, and i did not have lymphoma, but that is why i had it done! it is a very typical procedure for an ENT or general surgeon to perfom as an outpatient undder local anesthesia. Getting the node (as opposed to aspirating cells) defines the archtecture and the composition of cell by a hematopathologist. Some nodes show other things, benign and malignant. ...Read more

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For a neck biopsy (to rule out lymphoma) how many nodes do they take out?

Maybe one: Usually only one lymph node can be sufficient for the pathologist to study, as all the lymph nodes in a region are expected to show similar findings. If there are more than one lymph node that are enlarged, then sometimes more are removed. ...Read more

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How long does it take for a Lymphoma blood work panel take to get results? Had 2nd set of lymphoma panel done Friday and was curious and nervous.

How long does it take for a Lymphoma blood work panel take to get results? Had 2nd set of lymphoma panel done Friday and was curious and nervous.

It varies...: "Lymphoma blood work" is not a specific term. Some blood tests take a few hours (standard chemistries or blood counts) whereas others may take a day or more. If the blood was sent out to an outside lab, then shipping and reporting may take longer than the test itself. Also note, surveillance of lymphoma typically depends more on physical exam and radiology studies than it does on blood tests. ...Read more

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Question had skin biopsy do they automatically do a cd3 on every skin biopsy & if cd3 is negative does that r/o lymphoma or do u still have to watch?

Question had skin biopsy do they automatically do a cd3 on every skin biopsy & if cd3 is negative does that r/o lymphoma or do u still have to watch?

Complex question!: Cd3 is on t cells. Your doctor is looking for t cells in your skin biopsy, which can be present for many reasons including allergy. It looks like you have autoimmune disease (positive ANA in the past), so your doctor may be checking to see if your skin lesions are related to that. Based on what you've told me, lymphoma does not come to mind! ask your doctor what he/she is thinking! don't worry! ...Read more

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Can you suggest any alternative methods to treating hodgkin's lymphoma patients who respond negatively to avbd treatment?

Adcetris (brentuximab vedotin) / Nivolumab: There are several classes of drugs that offer good options for patients with Hodgkin lymphoma who have not responded to ABVD. The standard of care in a younger patient is intensive salvage chemotherapy and stem cell transplant. Other options would include Brentuximab or a PD1 inhibitor such as Nivolumab or Pembrolizumab. ...Read more

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Can a Hematologist rule out Lymphoma by examining your blood under a microscope?

Can a Hematologist rule out Lymphoma by examining your blood under a microscope?

Not necessarily.: Only certain types of lymphoma peripheralize and can be seen in a peripheral blood smear. Many require biopsy of an involved node, organ, or bone marrow with evaluation by a hematopathologist to make the diagnosis. Hope this helps! ...Read more

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Is it standard when doing a skin biopsy to run cd3 and if it's negative can it still be turning into lymphoma?

Is it standard when doing a skin biopsy to run cd3 and if it's negative can it still be turning into lymphoma?

No, it is not: A skin biopsy would only be done if there is a visible lesion(s) over the skin.Then a microscopic exam will reveal if there is any abnormal cells in the skin biopsy which may look like a lymphoma , in which case lymphoma markers like cd3 and others like it may be tested. ...Read more