Doctor insights on:
Do You Develop Drug Tolerance To Analgesia
Narcotics, yes: It's easy to develop tolerance to narcotic medications (morphine, demerol, dilaudid, vicodin, etc.) if they are taken for more than a few days. This means that it will take more and more drug to produce the same level of pain relief. Other types of analgesia, or pain relief, do not produce tolerance. These include local anesthetics, tylenol, (acetaminophen) or nsaids such as Ibuprofen or naprosyn. ...Read more
When one takes a drug, such as heroin or alcohol, repeatedly, 'tolerance' develops because more of the drug is needed to give the same effect on the body/brain; e.g. Liver enzymes r stimulated to metabolize the drug faster and faster. There may be a strong genetic predisposition to addiction, some studies suggesting that 1 of 10 people will become dependent on alcohol or some ...Read more
Yes: tolerance to opioids is not total - for example the small pupils that people get after use, or some side effects like constipation, may not develop any tolerance at all. But to the kinds of things that cause OD - respiratory depression, reduced level of consciousness, tolerance develops in most people who are taking a regular dose. This leads to the need for higher doses, but is protective for OD. ...Read more
The best way . . . : . . . . Is not to use it at all. Most chronic users report tolerance to the euphoric effects & need for increased frequency or increased amount of marijuana to get the same effect. Besides potentially inducing anxiety, panic, paranoia, and dysphoria, one's memory & motivation can be "off" even after the smoke is gone. Decreases in sperm count have also been seen, along with lung complications. ...Read moreSee 1 more doctor answer
How rarely do you have to take benzodiazepines such as Xanax (alprazolam) in order to not develop a tolerance?
Just not everyday: If you skip days fairly often, e.g., 2 or 3 times a week, you are unlikely to develop a tolerance over time. Any skipped day gives your body a chance to "reset". If you take it too many days in a row and then skip a day, you'll have withdrawal or rebound anxiety on the skipped day, and you'll know in the future to skip days more often. Psychological dependence is a different matter of course. ...Read moreSee 1 more doctor answer
If you develop a tolerance to benzodiazepines, can the tolerance be undone by stopping so they become effective again? Blow long do you need to stop?
Probably: As a rule tolerance will decrease if one stops being exposed to a chemical. However, this is not always the case. ...Read more
Can you tell me can I develop an opiate drug that does not have a tolerance level or form physical addiction?
Depends: If you are a chemist and work for pharm. Company you can try to develop the new drug following all regulations. At home it is illegal. ...Read more
Yes: Don't use them regularly.Get a more detailed answer ›
Why do some people become addicted to methadone if it is used to help quit a addiction to opiates?
More: Almost everyone will respond to medications in about the same way. Some local anesthetic types are broken down more easily (and therefore work less effectively) by one person than another. A good practitioner can almost always achieve good anesthesia by either changing the type, chemical mix or volume of the local anesthetic used without going into potentially toxic ranges ...Read more
Doctors, do you think I can develop a tolerance to potassium-sparing diuretic drugs over a long period of time?
No: Not unless your renal function deteriorates.Get a more detailed answer ›
Can you build tolerance to a pde5 inhibitor?How to reverse it/avoid it?What can I take to make it more effective?Will a detox help reverse tolerance?
Here are some...: What are your age and overall health background? Just like any drug, PDE-5i boosts up the marginal functional impairment so to enhance erectile dysfunction but would not stop continual accumulation of undesirable ill effects of aging. On top of that, as men age, esp. after 30, physiological replenishing ability gradually diminishes. So, nothing can reverse aging effect... ...Read more
If you develop a tolerance to Benzodiapemes can that tolerance be reversed by abstaining and if so how long does it take? Thanks
Benzo tolerance : yes, tolerance can be reversed however I don't know that there's good evidence to show how long that will take. However if you have been taking them for a long time frequently, then be aware that stopping them cold-turkey can cause withdrawl. Talk to your doctor about how to taper off, then see if it's healthy to consider using them again or finding an alternative ...Read more
Tolerance: Yes, sometimes higher doses of Cabergoline or bromocriptine are needed. It could be drug tolerance, or it could be another medication or condition that is increasing prolactin. Usually the prolactinoma will shrink with treatment. Sometimes, relatively high doses of Cabergoline are needed. Talk to your endocrinologist. ...Read more
Depends on med: It depends on the type of medication. Some medications will require that the dose be increased to obtain the same effects, such as pain medications. Other medications will require you to be changed to another medication in the same class or sometimes even a completely different class of medication. ...Read more
No: But you can not stop the medication abruptly, this can cause seizures, delirium and sometimes death. Decrease your dose slowly over time. Something like decreasing your total daily dose by 0.5mg every 3 days would be a place to start. If you can't do this on your own, then it's time to consider residential treatment. ...Read more
Take away? No: I don't believe you can absolutely remove the risk of abuse, addiction & habituation, some of which is genetically based. However, you can reduce the risk by using the lowest dose possible for the shortest amount of time necessary to achieve the goal. Most important, don't take it if you don't need it. Many times, ssris (class of antidepressants) can help mitigate need for benzodiazepine. ...Read more
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