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Doctor insights on: Do You Develop Drug Tolerance To Analgesia

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Do you develop drug tolerance to analgesia?

Do you develop drug tolerance to analgesia?

Narcotics, yes: It's easy to develop tolerance to narcotic medications (morphine, demerol, dilaudid, vicodin, etc.) if they are taken for more than a few days. This means that it will take more and more drug to produce the same level of pain relief. Other types of analgesia, or pain relief, do not produce tolerance. These include local anesthetics, tylenol, (acetaminophen) or nsaids such as Ibuprofen or naprosyn. ...Read more

Tolerance (Definition)

When one takes a drug, such as heroin or alcohol, repeatedly, 'tolerance' develops because more of the drug is needed to give the same effect on the body/brain; e.g. Liver enzymes r stimulated to metabolize the drug faster and faster. There may be a strong genetic predisposition to addiction, some studies suggesting that 1 of 10 people will become dependent on alcohol or some ...Read more


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Help can building tolerance to opiates also allow you to tolerate higher doses before od?

Help can building tolerance to opiates also allow you to tolerate higher doses before od?

Yes: tolerance to opioids is not total - for example the small pupils that people get after use, or some side effects like constipation, may not develop any tolerance at all. But to the kinds of things that cause OD - respiratory depression, reduced level of consciousness, tolerance develops in most people who are taking a regular dose. This leads to the need for higher doses, but is protective for OD. ...Read more

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Would having tolerance to dextromethorphan grant tolerance to oxycodone?

Would having tolerance to dextromethorphan grant tolerance to oxycodone?

maybe: Dextromethorphan is an unusual opioid that does not cross into the brain significantly. However, if someone was abusing dextromethorphan in large doses, it is possible to develop some degree of tolerance. ...Read more

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How do you avoid developing tolerance to marijuana?

How do you avoid developing tolerance to marijuana?

The best way . . . : . . . . Is not to use it at all. Most chronic users report tolerance to the euphoric effects & need for increased frequency or increased amount of marijuana to get the same effect. Besides potentially inducing anxiety, panic, paranoia, and dysphoria, one's memory & motivation can be "off" even after the smoke is gone. Decreases in sperm count have also been seen, along with lung complications. ...Read more

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How rarely do you have to take benzodiazepines such as Xanax (alprazolam) in order to not develop a tolerance?

How rarely do you have to take benzodiazepines such as Xanax (alprazolam) in order to not develop a tolerance?

Just not everyday: If you skip days fairly often, e.g., 2 or 3 times a week, you are unlikely to develop a tolerance over time. Any skipped day gives your body a chance to "reset". If you take it too many days in a row and then skip a day, you'll have withdrawal or rebound anxiety on the skipped day, and you'll know in the future to skip days more often. Psychological dependence is a different matter of course. ...Read more

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How much time do you have to take an antibiotic drug to become resistance to that drug?

How much time do you have to take an antibiotic drug to become resistance to that drug?

Antibiotic resistant: You do not become resistant. The bug does. And it can start with the first dose. So the drug kills 99% but 1% lives and keeps growing you can quickly end up with an antibiotic resistant bug. It is survival of the fittest even for germs. ...Read more

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Can you tell me can I develop an opiate drug that does not have a tolerance level or form physical addiction?

Can you tell me can I develop an opiate drug that does not have a tolerance level or form physical addiction?

Depends: If you are a chemist and work for pharm. Company you can try to develop the new drug following all regulations. At home it is illegal. ...Read more

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Why do some people become addicted to methadone if it is used to help quit a addiction to opiates?

Why do some people become addicted to methadone if it is used to help quit a addiction to opiates?

PAin and personality: Methadone is a powerful pain relieving medication. It does not have as much of the euphoria you see with other opioids , but still can make people feel better. Peopel who get addicted to Methadone have usually been addicated to other medications. ...Read more

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What can they give you if you have tolerance to local anesthesia?

What can they give you if you have tolerance to local anesthesia?

More: Almost everyone will respond to medications in about the same way. Some local anesthetic types are broken down more easily (and therefore work less effectively) by one person than another. A good practitioner can almost always achieve good anesthesia by either changing the type, chemical mix or volume of the local anesthetic used without going into potentially toxic ranges ...Read more

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How to know if some of us are prone to drug addiction and alcohol dependence?

How to know if some of us are prone to drug addiction and alcohol dependence?

Drug and alcohol : Addictions tend to have a strong hereditary component as well as a learned behavior. If you have grown up in a family that has a tendency to have drug and alcohol problems be cautious and pay attention to your drinking. ...Read more

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Can you build tolerance to a pde5 inhibitor?How to reverse it/avoid it?What can I take to make it more effective?Will a detox help reverse tolerance?

Can you build tolerance to a pde5 inhibitor?How to reverse it/avoid it?What can I take to make it more effective?Will a detox help reverse tolerance?

Here are some...: What are your age and overall health background? Just like any drug, PDE-5i boosts up the marginal functional impairment so to enhance erectile dysfunction but would not stop continual accumulation of undesirable ill effects of aging. On top of that, as men age, esp. after 30, physiological replenishing ability gradually diminishes. So, nothing can reverse aging effect... ...Read more

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How long do you have to be off narcotic pain medication before you can drive?

How long do you have to be off narcotic pain medication before you can drive?

Narctoics & driving: The answer entirely depends on which narcotic and how it is taken. The different meds have different 1/2 lives listed and that reflects the 1/2 time for clearence. But clearence also is affected by an individuals live and kidney function. ...Read more

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If you develop a tolerance to Benzodiapemes can that tolerance be reversed by abstaining and if so how long does it take? Thanks

Benzo tolerance : yes, tolerance can be reversed however I don't know that there's good evidence to show how long that will take. However if you have been taking them for a long time frequently, then be aware that stopping them cold-turkey can cause withdrawl. Talk to your doctor about how to taper off, then see if it's healthy to consider using them again or finding an alternative ...Read more

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Can prolactinomas build tolerance to medication?

Tolerance: Yes, sometimes higher doses of Cabergoline or bromocriptine are needed. It could be drug tolerance, or it could be another medication or condition that is increasing prolactin. Usually the prolactinoma will shrink with treatment. Sometimes, relatively high doses of Cabergoline are needed. Talk to your endocrinologist. ...Read more

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What do you do when you build a tolerance to medication?

What do you do when you build a tolerance to medication?

Depends on med: It depends on the type of medication. Some medications will require that the dose be increased to obtain the same effects, such as pain medications. Other medications will require you to be changed to another medication in the same class or sometimes even a completely different class of medication. ...Read more

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Do you have to go to drug rehab to get off of klonopin (clonazepam)?

Do you have to go to drug rehab to get off of klonopin (clonazepam)?

No: But you can not stop the medication abruptly, this can cause seizures, delirium and sometimes death. Decrease your dose slowly over time. Something like decreasing your total daily dose by 0.5mg every 3 days would be a place to start. If you can't do this on your own, then it's time to consider residential treatment. ...Read more

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So can you modify benzodiazepine dosages to take away addiction and habituation potential?

So can you modify benzodiazepine dosages to take away addiction and habituation potential?

Take away? No: I don't believe you can absolutely remove the risk of abuse, addiction & habituation, some of which is genetically based. However, you can reduce the risk by using the lowest dose possible for the shortest amount of time necessary to achieve the goal. Most important, don't take it if you don't need it. Many times, ssris (class of antidepressants) can help mitigate need for benzodiazepine. ...Read more

Analgesia (Definition)

Analgesia is the decrease or absence of pain sensibility without a loss of consciousness. Experiencing pain relief may happen without a person ...Read more


Dr. Satvinder Dhesi
1,456 doctors shared insights

Pain Management (Definition)

Pain management is the control of pain through medication, ...Read more