Doctor insights on:
Do Steriods From Chemo Cause Avascular Necrosis
Possibly but others: Although avascular necrosis can be related to corticosteroids it is important to know that there are other causes of avascular necrosis. There is a decrease in blood flow to the area involved. Although corticosteroids can be associated, it depends on dose and time and thus chemo steroids are less likely to be associated. Other causes: alcohol, joint injury and increased pressure ...Read moreSee 1 more doctor answer
Yes: This is a known complication of taking steroids, especially if you had to take prolonged courses during your chemo regimen (for acute lymphoblastic leukemia, for example). Depending on the location and extent, treatment ranges from physical therapy and waiting, to some orthopedic surgery procedures. If you are still on steroids, you and your oncologist will have the risk/benefit ratio of stopping. ...Read more
Does chemotherapy cause avascular necrosis? Does having cancer treatments such as chemo or radiation increase my risk of avascular necrosis?
Perhaps: Certain chemo and radiation can cause avn. Certain cancers and disease can as well. It is best to discuss this with your oncologist or internist. ...Read more
Does chemotherapy cause avascular necrosis? Does having cancer treatments such as chemo or radiation increase my risk of avascular necrosis? .
Possible: Certain therapeutics, although not chemotherapy, that are commonly used in cancer patients can be associated with avascular necrosis (avn). Examples of these agents include: zometa, xgeva (denosumab) and avstin that can be associated with osteonecrosis of the jaw. Dexamethasone and radiation therapy can also cause avn. ...Read moreSee 1 more doctor answer
Still unknown: Even though there is this very well-established connection between chronic Prednisone use and avascular necrosis, how this occurs remains unclear. Numerous hypotheses abound. Some argue that increased lipids seen with steroids cause vessels to joints to clog, leading to oxygen starvation & bone death. A more popular view is that vessel (venous) walls undergo thickening, leading to poor blood flow. ...Read more
Early avascular necrosis hip. No surgery while on immunosuppresant (SLE complications). What can I do to slow progress of the AVN? Not on steroids.
See your orthopedist: Lupus is a frequent cause of AVN, particularly if on steroids. Treatment usually consists of pain relief from NSAIDs and sometimes opiates. Some studies show that alendronate used with Ca and vitamin D may slow progression, but don`t use long term osteoporosis drugs as they stay there a long time and some hae even been implicated in AVN.See PT for gentle exercise and avoidance of injury. ...Read more
Avascular Necrosis: Due to effect on blood vessels, causing interruption of blood supply to the bone. ...Read more
Why is the " corticosteroid administration " can cause " avascular necrosis" ?
* i need the mechanism how does the " corticosteroid" work.
Not Known: While it is generally agreed that the key problem in avn is compromised blood flow to the bone, the mechanism by which corticosteroid use contributes to avn is not known. It is important to remember that this is a rare and not a common problem in corticosteroid users. ...Read more
I suffer from avascular necrosis in the hip joint and secondary osteoarthritis. Can i take creatine if i suffer from this?
Would vascular necrosis cause elevated LDH? I go soon for MRI hip to R/o FAI and necrosis. My LDH is 270 nobody knows why
Vascular necrosis: could cause LDH to rise, but LDH is not specific for any single diagnosis ...Read more
Can nicotine cause avascular necrosis as it constricts blood vessels? I know it stopped my recent bone graft in a spinal fusion from growing properly.
Maybe: Smoking is well-known to impair new blood vessel growth into areas of bone fusion and prevent good healing. There are thousands of chemicals in smoke. Nicotine alone has been well studied and tends to show poor bone formation and mineralization. So using nicotine as a supplement instead of smoking still is a risk for your spinal fusion. You have one spine -- take good care! Good Luck! ...Read moreSee 1 more doctor answer
Can aromatose inhibitors cause osteonecrosis of the jaw? I know bisphosphanates can, but what about other meds?
They do not!: Since they lower Estradiol levels, they can make osteoporosis more likely, but the do not cause osteonecrosis of the jaw! obviously used for estrogen receptor positive breast ca, Evista (raloxifene) would be a good trade for your tamoxifen, in the sense that it would prevent osteoporosis as well as breast ca! ...Read more
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