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Doctor insights on: Do Steriods From Chemo Cause Avascular Necrosis

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Do steriods from chemo cause avascular necrosis?

Do steriods from chemo cause avascular necrosis?

Possibly but others: Although avascular necrosis can be related to corticosteroids it is important to know that there are other causes of avascular necrosis. There is a decrease in blood flow to the area involved. Although corticosteroids can be associated, it depends on dose and time and thus chemo steroids are less likely to be associated. Other causes: alcohol, joint injury and increased pressure ...Read more

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Dr. Charles Glueck
461 doctors shared insights

Osteonecrosis (Definition)

-death of bone. This is due 2 loss of blood supply 2 a certain bone part. Common after some injuries such as fractured navicular in the wrist, dislocation of the hip. Some R due 2 drugs , especially steroids, also alcoholism, in these cases it's usually ...Read more


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Could using steriods from chemo cause avascular necrosis?

Could using steriods from chemo cause avascular necrosis?

Yes: This is a known complication of taking steroids, especially if you had to take prolonged courses during your chemo regimen (for acute lymphoblastic leukemia, for example). Depending on the location and extent, treatment ranges from physical therapy and waiting, to some orthopedic surgery procedures. If you are still on steroids, you and your oncologist will have the risk/benefit ratio of stopping. ...Read more

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Why does steroids cause avascular necrosis?

Why does steroids cause avascular necrosis?

We are not sure: We are not sure but there is a linkage seen whether it may be more related ti the underlying problem for which the steroids are given as treatment in the first place. ...Read more

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Why do steroids cause avascular necrosis of the femur head?

Why do steroids cause avascular necrosis of the femur head?

Unknown: No one really knows for sure. However, it has been shown that steroids cause elevation of lipids. In rabbits, steroids cause collections of lipids called an embolism. The emboli caused avascular necrosis of the femoral heads in the studied rabbits. ...Read more

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Does chemotherapy cause avascular necrosis? Does having cancer treatments such as chemo or radiation increase my risk of avascular necrosis? .

Does chemotherapy cause avascular necrosis? Does having cancer treatments such as chemo or radiation increase my risk of avascular necrosis?

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Perhaps: Certain chemo and radiation can cause avn. Certain cancers and disease can as well. It is best to discuss this with your oncologist or internist. ...Read more

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Does chemotherapy cause avascular necrosis? Does having cancer treatments such as chemo or radiation increase my risk of avascular necrosis? . .

Possible: Certain therapeutics, although not chemotherapy, that are commonly used in cancer patients can be associated with avascular necrosis (avn). Examples of these agents include: zometa, xgeva (denosumab) and avstin that can be associated with osteonecrosis of the jaw. Dexamethasone and radiation therapy can also cause avn. ...Read more

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How does prednisone cause avascular necrosis?

How does prednisone cause avascular necrosis?

Still unknown: Even though there is this very well-established connection between chronic Prednisone use and avascular necrosis, how this occurs remains unclear. Numerous hypotheses abound. Some argue that increased lipids seen with steroids cause vessels to joints to clog, leading to oxygen starvation & bone death. A more popular view is that vessel (venous) walls undergo thickening, leading to poor blood flow. ...Read more

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Early avascular necrosis hip. No surgery while on immunosuppresant (SLE complications). What can I do to slow progress of the AVN? Not on steroids.

See your orthopedist: Lupus is a frequent cause of AVN, particularly if on steroids. Treatment usually consists of pain relief from NSAIDs and sometimes opiates. Some studies show that alendronate used with Ca and vitamin D may slow progression, but don`t use long term osteoporosis drugs as they stay there a long time and some hae even been implicated in AVN.See PT for gentle exercise and avoidance of injury. ...Read more

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Why is avascular necrosis caused by steroid use and/or alcohol use?

Why is avascular necrosis caused by steroid use and/or alcohol use?

Avascular Necrosis: Due to effect on blood vessels, causing interruption of blood supply to the bone. ...Read more

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Why is the " corticosteroid administration " can cause " avascular necrosis" ? * i need the mechanism how does the " corticosteroid" work.

Why is the " corticosteroid administration " can cause " avascular necrosis" ?
* i need the mechanism how does the " corticosteroid" work.

Not Known: While it is generally agreed that the key problem in avn is compromised blood flow to the bone, the mechanism by which corticosteroid use contributes to avn is not known. It is important to remember that this is a rare and not a common problem in corticosteroid users. ...Read more

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I suffer from avascular necrosis in the hip joint and secondary osteoarthritis. Can i take creatine if i suffer from this?

I suffer from avascular necrosis in the hip joint and secondary osteoarthritis. Can i take creatine if i suffer from this?

Avascular necrosis: You need to find out if your avascular necrosis is secondary (alcholism, big dose long term corticosteroids) or primary (coagulation disorder, enos mutation). Once the etiology is known, then medical therapy approaches can be put in place. Would not use cretine now. ...Read more

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Can coffee cause avascular necrosis?

Can coffee cause avascular necrosis?

No: Although caffeine isn't good for bone density, regular consumption of coffee doesn't cause avascular necrosis. ...Read more

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Can the cortef (hydrocortisone) steriod for a brain tumor cause me to get osteonecrosis?

Can the cortef (hydrocortisone) steriod for a brain tumor cause me to get osteonecrosis?

Maybe: Corticosteroids are known to cause avn (osteo necrosis). The hip is the most common site. Even with this association however, not everyone on steroids gets avn. If you start to have pain while on this treatment notify your doctor. ...Read more

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Can nicotine cause avascular necrosis as it constricts blood vessels? I know it stopped my recent bone graft in a spinal fusion from growing properly.

Can nicotine cause avascular necrosis as it constricts blood vessels? I know it stopped my recent bone graft in a spinal fusion from growing properly.

Maybe: Smoking is well-known to impair new blood vessel growth into areas of bone fusion and prevent good healing. There are thousands of chemicals in smoke. Nicotine alone has been well studied and tends to show poor bone formation and mineralization. So using nicotine as a supplement instead of smoking still is a risk for your spinal fusion. You have one spine -- take good care! Good Luck! ...Read more

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Can topical steroid ointments for eczema have any affect whatsoever on tendon disorders? Recovering from levaquin-induced bilateral Achilles damage.

No direct linkage: Topical steroids act locally for the most part. Ask your physician who prescribed the specific medication to make sure there is no known tendon-related side effects, especially since you have already had Levaquin (levofloxacin) induced tendon trouble in the past. ...Read more

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Can aromatose inhibitors cause osteonecrosis of the jaw? I know bisphosphanates can, but what about other meds?

Can aromatose inhibitors cause osteonecrosis of the jaw? I know bisphosphanates can, but what about other meds?

They do not!: Since they lower Estradiol levels, they can make osteoporosis more likely, but the do not cause osteonecrosis of the jaw! obviously used for estrogen receptor positive breast ca, Evista (raloxifene) would be a good trade for your tamoxifen, in the sense that it would prevent osteoporosis as well as breast ca! ...Read more

Dr. Pietro Seni
220 doctors shared insights

Avascular Necrosis (Definition)

Also known as osteonecrosis, it is the death of bone from interruption of blood supply. This can result in tiny bone fractures and eventual destruction ...Read more


Necrosis (Definition)

Necrosis is the the death of cells and tissue. In dentistry, root canals are often needed when the pulp tissue inside a ...Read more