Top
20
Doctor insights on: Diseases With Low Antibody Levels

Share

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


2

2
Why are cu and ceruloplasmin levels paradoxically low in wilson's disease?

Why are cu and ceruloplasmin levels paradoxically low in wilson's disease?

Minor mystery: Copper is low because ceruloplasmin is low; most copper in the blood is carried on the protein. Nobody really knows why ceruloplasmin tends to be low in Wilson's, and I hope that you also know that in about 30% of Wilson's patients it is not low at all, making is a very poor screening test. ...Read more

See 1 more doctor answer
4

4
Elevated levels of antinuclear antibodies and bilirubin go with what disease?

Elevated levels of antinuclear antibodies and bilirubin go with what disease?

Autoimmune disease: Elevated ANA associated with autoimmune diseases. Elevated bilirubin associated with gall bladder and pancrease (pancrelipase). Not aware of how the two can be related. ...Read more

5

5
For what reason serum cu and ceruloplasmin levels are paradoxically low in wilson's disease?

For what reason serum cu and ceruloplasmin levels are paradoxically low in wilson's disease?

Not paradoxical: The problem is that copper can't get out of certain cells. The reason for ceruloplasmin being low is under study; since it carries copper, this metal also tends to be low. Checking serum copper and serum ceruloplasmin as a screen for wilson's misses up to a quarter of cases, especially if the person is already sick with anything. ...Read more

6

6
What are possible causes of highly elevated ImM levels with low ImG levels with no monoclonal gammopathy present?

What are possible causes of highly elevated ImM levels with low ImG levels with no monoclonal gammopathy present?

May not be a problem: This may depend on your genetic background and not be a medical problem. We would need an explanation of your problems, blurred vision, night sweats. Why are you on opiates ...Read more

See 2 more doctor answers
7

7
Have borderline low C3 and C4 complement levels and low 1:80 titre positive ANA speckled. With symptoms relating to sle and sjorgrens - atypical ?

Have borderline low C3 and C4 complement levels and low 1:80  titre positive ANA speckled. With symptoms relating to sle and sjorgrens - atypical ?

Atypical for what?: Rheumatic disease generally requires a cluster of suggestive symptoms which is supported by lab studies. I do not know your symptoms, but your labs are not particularly suggestive of anything. ...Read more

9

9
Does low c3c combined with low phosphate levels always mean you have kidney disease?

Does low c3c combined with low phosphate levels always mean you have kidney disease?

No: Often c3 complement levels are a nonspecific marker of other possible problems like infection or autoimmune inflammation or lupus perhaps. But if you have normal kidney function otherwise that may not be the case. You might need to have your kidney function looked at more closely to be sure of this with other tests first. ...Read more

11

11
Can u have platelet dysfunction with petechiae but normal CBC / low normal plts, low rdw, low immunoglobulin, lack of antibody formation to vaccine?

Can u have platelet dysfunction with petechiae but normal CBC / low normal plts, low rdw, low immunoglobulin, lack of antibody formation to vaccine?

Yes, but what you: Described is a complicated situation that would require in person evaluation for a proper diagnosis and treatment. All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. ...Read more

12

12
Lab results as follows: ANA w/titre and pattern 1:320 and thyroid peroxidase ab 484.0....Are the two related? Would hashimoto's cause high ANA level?

Lab results as follows: ANA w/titre and pattern 1:320  and thyroid peroxidase ab 484.0....Are the two related? Would hashimoto's cause high ANA level?

No: You have an elevated thyroid peroxidase (tpo) antibody because you have a tendency towards autoimmunity. The elevated tpo causes hoshimoto's. The tendency towards autoimmunity causes the high ANA level. ...Read more

13

13
Recent diagnosis of collagenous colitis with high platelets, high IgE and eos. What do the elevated blood levels mea?

Recent diagnosis of collagenous colitis with high platelets, high IgE and eos. What do the elevated blood levels mea?

IgE: How high is high? 100s or 1000s is the ige? You need to be seen by an allergist and you need to have some tests done. Did they find eosinophils in the colon biopsies? ...Read more

14

14
Can high blood protein levels or Sjogren's syndrome cause elevated liver enzymes test results?

Can high blood protein levels or Sjogren's syndrome cause elevated liver enzymes test results?

Sjogren possible: But not likely with high serum protein. There is a condition called primary biliary cirrhosis that is associated with Sjogren and certain drugs used for Sjogren can potentially affect liver as well. Best thing to do is to see/talk to a rheumatologist. ...Read more

15

15
In blood work, does elevated gamma globulin (m-spike) often cause the total serum globulin to be elevated as well?

Tt could: Since, total globulin level usually includes all kinds of globulins (alpha, m spike etc). An immunoelectrophoresis can further characterize the m spike. ...Read more

See 1 more doctor answer
16

16
Can you have low TSH with Hashimoto's (antibodies are present)?

Can you have low TSH with Hashimoto's (antibodies are present)?

Yes, transiently: Hashimoto's thyroiditis can go through a phase of thyroid hyperactivity early in the course of disease and that would be associated with low TSH. Sooner or later enough thyroid is destroyed that thyroid functions declines and TSH rises. ...Read more

17

17
What condition(s) causes someone to have high total serum protein, high albumin, normal globulin and high total calcium levels?

What condition(s) causes someone to have high total serum protein, high albumin, normal globulin and high total calcium levels?

Dehydration.: There are no diseases that specifically increase albumin. Therefore in order to get an elevated concentration there must be a decrease in the amount of water in the system. This would also account for the normal globulin. Calcium is bound to Albumin so that elevated Albumin will elevate your calcium levels as well. ...Read more

18

18
I have antiphospholipid syndrome(aps), with anticardiolipin antibodies igg/gpl extremely high. Others are normal. What problems arise with a high igl?

I have antiphospholipid syndrome(aps), with anticardiolipin antibodies igg/gpl extremely high. Others are normal. What problems arise with a high igl?

Antiphospholipid syn: Antiphospholipid syndrome (aps) is a disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss. Some patients with aps have no evidence of any definable associated disease, while, in other patients, aps occurs in association with sle or another rheumatic or autoimmune disorder. Traditionally, these have been referred to as primary or secondary aps, respectivel. ...Read more

See 1 more doctor answer
19

19
Why does one have low cortisol and high potassium levels in addison's disease?

Why does one have low cortisol and high potassium levels in addison's disease?

See below: Addison's disease is a state of low cortisol or hypocortisolism. In addition to cortsiol, the adrenal galnd also produces a very important hormone called aldosterone. The latter is responsible for reabsorbing sodium from the urine in exchange for potassium. If such hormone is not produced in sufficient quantity (either isolated or in conjunction with cortisol), potassium levels go up. ...Read more

See 1 more doctor answer
20

20
Hi: What is significance of high IGM, (twice top reference range level), very high IGE, with low IGG, low IGG subclasses, and low IGA? Thanks much!

Hi: What is significance of high IGM, (twice top reference range level), very high IGE, with low IGG, low IGG subclasses, and low IGA?  Thanks much!

More info needed: The question asked can be intreperted in many ways. Normally these are levels in relation to a disease. A high IGM means recent infection, a high IGE means something allergic is bothering you and low IGG means less memory antibodies for an old infection. Low IGA is antibody for your gut/intestines. Hopefully this helps. See your doctor for more answers. ...Read more