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Doctor insights on: Diseases Of Tissues

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How does one identify Peyronie's disease scar tissue? Feel, look like?

How does one identify Peyronie's disease scar tissue? Feel, look like?

Site of curvature: Peyronie's disease occurs when the normally elastic tissue within the penis is replaced with non-elastic "scar" tissue ("plaque"). This can often be felt at the site where the penis is curving: it will be harder than the surrounding tissue. ...Read more

Tissue (Definition)

The body is composed of tissue that are classically described as beiing derived from three basic embyonic layers known as the endoderm, mesoderm and ectoderm that then differentiate into the structures that compose the body such as skin, soft tissues, bone, muscle, organs, etc. Stem cells are not differentiated and have the potential to ...Read more


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How would one identify Peyronie's disease scar tissue? How would it feel and look?

How would one identify Peyronie's disease scar tissue? How would it feel and look?

Hard plaques: Thick hard palpable plaques with notebale curvature of the penis when you have an erection. Consult your physician for a definitive exam. ...Read more

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How do I identify Peyronie's disease scar tissue or plaque? And what is the difference between the 'scar tissue' and 'plaque'?

How do I identify Peyronie's disease scar tissue or plaque? And what is the difference between the 'scar tissue' and 'plaque'?

Same, but ...: Plaque is a specific descriptive term to denote the shape of the scar of Peyronie's disease, and scar tissue is a general term to describe the common microscopic picture of healing/healed tissue after injury by various reasons, resulting in disruption of local circulation and cell arrangement. The plaque may widely vary in size & shape so some plaques are barely palpable, and others, obvious. ...Read more

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What do my celiac disease tissue transglutaminase test results mean?

What do my celiac disease tissue transglutaminase test results mean?

Depends...: If the test was performed to identify whether you have celiac disease, an unequivocally elevated ttg value is diagnostic for celiac disease. If you are IgA deficient, and the only ttg assayed was iga, you may miss a diagnosis of celiac disease due to a falsely negative result. If you have celiac disease, ttg can be used to assess how compliant you may be with strict dietary gluten avoidance. ...Read more

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My penis has a very severe curve downwards starting at the base. I read about a disease involving scar tissue and there is none and no pain. ?

 My penis has a very severe curve downwards starting at the base. I read about a disease involving scar tissue and there is none and no pain. ?

Injury or Peyronies: You did not say how long this bend has been there. Assuming no injury , you are also a little young for Peyronies disease. However your best move is to go to a Urologist. There are several more questions that need an answer and whatever treatment if nec. ...Read more

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What do my celiac disease tissue transglutaminase iga/igg results mean?

What do my celiac disease tissue transglutaminase iga/igg results mean?

Anti-transglutaminas: Antibodies that bind to transglutaminase could indicate the presence of celiac disease. This is a sugggestive test only. Negative testing does not definitively rule-out celiac dz and positive testing does not confirm the diagnosis. An intestinal biopsy would be the most helpful test. ...Read more

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Is hughes disease a vascular disease or connective tissue disease? I forgot to ask rheumatologist when recently diagnosed.

Is hughes disease a vascular disease or connective tissue disease? I forgot to ask rheumatologist when recently diagnosed.

All: Hughes disease or antiphaspholipid synrome, has sticky blood causes clotting in unwanted places and time, due to thrombosis depending on the site causes variety of symptoms , TIA pe , deep vein thrombosis miscarriage etc could be immunological, as antiphaspho lipid antibodies are found , some times lupus also found in hughes syn. Warfarin is used ...Read more

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Is it normal to have CT scan say stable increased lobulated density in anterior superior mediastinum may represent residual disease vs thymic tissue?

Is it normal to have CT scan say stable increased lobulated density in anterior superior mediastinum may represent residual disease vs thymic tissue?

Mediastinum: Of course it depends on many factors. It's normal to see thymic tissue until early 20s is seen in fewer than 50% of people over 40. This density can be possibly be anything including normal, reaction to infection, thymic cysts, or hyperplasia from systemic disease. Fortunately it is stable, but a conversation with your doc and radiologist would be the best thing moving forward. ...Read more

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I'm 35 chest x-ray-showed mild thoracic degenerative disease. Have connective tissue disease. Could that be cause? How to prevent further damage?

I'm 35 chest x-ray-showed mild thoracic degenerative disease.  Have connective tissue disease. Could that be cause? How to prevent further damage?

Disks vs spine: If you have degerative disk disease, loosing weight, staying well hydrated, good posture, and maybe some otc joint supplement could help. Degeneration of the spine may be osteoporosis and needs evaluation but calcium and vitamin d can reduce that risk. ...Read more

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How does Alzheimer's disease affect the brain tissue?

How does Alzheimer's disease affect the brain tissue?

Multiple ways: Deposits of amyloid (plaques) and tau (tangles). Disruption of synaptic function. Loss of neurotransmitters such as acetylcholine. Neuronal death. ...Read more

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Thyroid disease and now connective tissue disease as well, what's going on with my body?

Thyroid disease and now connective tissue disease as well, what's going on with my body?

Autoimmune condition: Hashimoto's and graves' are two thyroid diseases caused by the body's immune system attacking thyroid gland. In hashimoto's, the attack causes thyroid underfunction, while in graves', the attack causes overfunction. People with autoimmune thyroid disease are more prone to autoimmune connective tissue disease (lupus, rheumatoid arthritis, etc) when immune system attacks joints, skin, muscles, etc. ...Read more

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What is a "connective tissue disease"? Had punch biopsy on rash, suggestive of early connective tissue disease. What is "connective tissue?"

What is a "connective tissue disease"? Had punch biopsy on rash, suggestive of early connective tissue disease. What is "connective tissue?"

Connective tissue: This is a constellation of disease affecting the supporting tissue throughout the body. It involves fat, cartilage,bone.there are different types with names such as Eleros Danlos , Marfans syndrome, Osteogensis imperfecta, they are all a result of gene dysfunction.ie are inheritable disorders. Most are fairly uncommon. The treatment varies depending on the specific areas involved ...Read more

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Is Palmar fibrosis a autoimmune disease or Mixed connective tissue disease?

Is Palmar fibrosis a autoimmune disease or Mixed connective tissue disease?

No: It's neither. It's an overgrowth of fibrous tissue that's poorly understood. Sometimes an injection can break it, or surgery's an option. Best wishes. ...Read more

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If autonomic dysfunction caused by connective tissue disease.Would treating connective tissue disease control the autonomic disease sx? Ie prednisone?

If autonomic dysfunction caused by connective tissue disease.Would treating connective tissue disease control the autonomic disease sx? Ie prednisone?

Very possible: Autonomic dysfunction is a frustrating condition. If you did every measure that your doc suggested but to no avail, treating connective tissue disease with steroid may possibly help. ...Read more

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Skin biopsy shows early connective tissue disease. What is connective tissue disease? Why would it cause a chest rash? Or flushing w/ stress, emotion?

Skin biopsy shows early connective tissue disease. What is connective tissue disease? Why would it cause a chest rash? Or flushing w/ stress, emotion?

Get 2nd pathologist: "Connective tissue disease" was an obsolete word for the lupus / scleroderma / dermatomyositis family decades ago. Unless this is a second-hand report of a biopsy that showed nonspecific inflammatory changes that anybody can have, I would ask that the case be reviewed by another pathologist if the rash might be a real problem. Lots of folks flush with stress ("stress urticaria"); it's normal. ...Read more

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Do you think there are specific new connective tissue diseases not recognized yet (but lumped into undifferentiated) but will be named in the future?

Do you think there are specific new connective tissue diseases not recognized yet (but lumped into undifferentiated) but will be named in the future?

No: First, i personally do not believe in the concept of undifferentiated connective tissue disorders and I do not believe in mixed connective tissue disorders. Followed long enough, most turn out to be lupus. ...Read more

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Have undiff conn tissue disease and on methotrexate x 3 months.Went from daily bad days to 1-2 bad days/month. Is this still considered uncontrolled?

Have undiff conn tissue disease and on methotrexate x 3 months.Went from daily bad days to 1-2 bad days/month. Is this still  considered uncontrolled?

See below: It sounds like have improved considerably but still have some disease activity. As a doctor we would like to have you as close to 100% improved. Hope that helps. ...Read more