Doctor insights on:
Diseases Similar To Parkinson's Disease
Opposites: Parkinson's disease is a condition with loss of ability to initiate movements. (other than involuntary tremor in 70 %) One can see excessive involuntary movements with peak dose dyskinesias in treating it. Athetosis and choreaform movements are seen in Juvenile Rheumatoid Arthritis and Sydenham's chorea (from rheumatic fever) One can also see this with tardive dyskinesia and neuroacanthocytosis. ...Read more
Some ideas: Both Huntingtons and Parkinsons are disorders that affect movement. Cortical basal ganglia degeneration is an illness similar to these, based on the area of the brain that is affected. Sometimes a stroke affecting the basal ganglia can appear like Parkinsons (vascular Parkinsons). Sometimes MS can cause symptoms like these illnesses. Hope that helps ...Read more
Yes: Although the causes are multifactorial and sometimes poorly understood, there is a hereditary component. Keep in mind, that even though a parent may have it, it does not mean that it will be necessarily passed on. The tendency, however, may be there. ...Read more
Parkinsonism: Yes. There is evidence that certain chemicals and pesticides can cause parkinsonism. We are now experiencing an epidemic of parkinsonism but it is not clear why this is happening. ...Read more
In Parkinson's disease, does dopamine loss happen mainly in the striatum or does it occur in the s.Niagra too?
Parkinson: Basal ganglia, which includes both.Get a more detailed answer ›
Can you tell me in Parkinson's disease, does dopamine loss occur merely in the striatum or does it occur in the s.niagra too?
Pigmented nuclei: The dopamine loss involves predominantly the basal ganglia area, but also involves dorsal vagal nucleus, substantial nigra, and areas of any dopamine interaction within brain and brain stem. But, to be complete, Parkinson's is a multi-neurotransmitter degenerative deficiency syndrome with other neurotransmitter systems involved. ...Read more
Sometimes: Parkinson disease is the most common cause of parkinsonism, a symptomatic triad of tremor, muscular rigidity, and slow movement. Most of parkinson disease is caused by contributions of multiple genes, no one of which is necessary nor sufficient, aided by poorly defined environmental factors. About seven types of parkinson disease are inherited in an autosomal dominant or recessive pattern. ...Read more
It can be, yes: As a general rule, the younger the age of onset (<45yo is early onset), & the more affected relatives (especially close ones), then the more likely it is genetic & the higher the risk to blood relatives. Average age of pd onset is 58. The older you are @ disease onset, the less likely it is genetically inheritable. Look @ this link for help on genetics: http://www. Ncbi. Nlm. Nih. Gov/books/nbk1223/. ...Read more
There are some hereditary factors but they are seemingly minor.
If you have a first-degree relative with parkinson’s disease you are more likely to get it, but the risk is small (< 5 % according to mayo clinic reports). It can run very strongly in some families in rare situations of abnormalities of alpha-synuclein synthesis or protein disposal problems. ...Read more
Good Rx available!!: Dopamine meds are mainstay of treatment. Modern therapy recommends longer lasting, milder potency meds first: Azilect (mao-b selective inhibitor) & Dopamine agonists (requip xl/mirapex er/neupro). After they've been maximized & stronger meds are needed to adequately manage symptoms, then sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together) are begun. Tailor rx with side effects in mind for each person. ...Read more
Neurodegenerative: Parkinson’s results from destruction of dopamine-producing neurons in part of the brain (substantia nigra). A lack of these neurons causes decreased excitation of the motor part of the brain. This results in the classic signs of a resting tremor (“pill-rolling”), slowness of movement (shuffling steps), rigidity (resistance to being moved), and postural instability (balance issues). ...Read more
Not Parkinson's: Parkinson's disease is a disorder of the brain characterized by slowness of movement, rigidity of muscles and is caused by a deficiency of Dopamine in the brain. Many drugs such as the anti-psychotics can cause a parkinson's-like picture, as can some severe infections and metabolic disorders. I believe the term is more of a lay term than what is truly found in medical books. ...Read more
Parkinsons disease is often diagnosed by a history and a clinical exam. The history helps to evaluate if there are any medicines or other factors that can explain the symptoms. The exam should show evidence of muscular rigidity, postural instability or slowness of movement- these are clinical features that are needed to make the diagnosis.
Hope that helps! ...Read more
Mostly not inherited: The vast majority of people with Parkinson's seem to get it sporadically, that is without any clear inheritance from family. That being said, we've found around 12 genetic variants that seem to greatly increase the risk of developing pd in some families. Some of them are recessive (rarely crops up), and some are dominant (50% chance of getting it from 1 affected parent). ...Read more
History and exam: Parkinson's is usually diagnosed based upon it having very characteristic symptoms and exam findings - namely asymmetric (i.e. Usually starts on one side) tremor at rest, slowness of movements (bradykinesia), and stiffness (rigidity). There are some nuclear medicine tests that show the pathology of pd fairly reliably, but they are fairly new and considered experimental by most insurers. ...Read more
Yes: Parkinson-like symptoms can be an initial manifestation of Wilson's disease. Wilson's disease usually occurs in younger people, however. If there is any confusion in diagnosis, Wilson's disease can usually be diagnosed through a combination of blood tests, urine tests, and/or an eye exam. Hope this helps. ...Read more
Yes, many reasons: Sleep disturbances with resultant auto accidents, trauma from falling with fractures and subsequent complications, swallowing difficulties with aspiration pneumonia, blood pressure drops resulting in fainting or falling, associated dementia causing further complications. Since a disease of older adults, any of the above could be catastrophic. ...Read more
Modernize Treatment!: Dopamine meds are mainstay of treatment. Modern therapy recommends longer lasting, milder potency meds first: Azilect (mao-b selective inhibitor) & Dopamine agonists (requip xl/mirapex er/neupro). After they've been maximized & stronger meds are needed to adequately manage symptoms, then sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together) are begun. Tailor rx with side effects in mind for each person. ...Read more
Good History & Exam!: Physical symptoms can include tremor of limbs at rest>in posture or in action; slow movements & stiff (rigid) muscles causing quiet facial emotions, softer voice, bent forward head & neck posture, decreased arm swing, slow-shuffled walk, small/scratchy penmanship, etc. Non-physical symptoms can include cognitive decline, depression, anxiety, sleepiness, constipation, ed, low bp, acting-out dreams. ...Read more
Control what u can: Though there is no cure for patkinson's, strategies such as medications and remaining active (especially lots of walking, yoga, tai chi, etc) can help ameliorate symptoms, delay developing disability, and some meds (azilect) and exercise may even slow down the disease. Sometimes a support group can help. Also make sure your doctor addresses common non-movement issues in pd like depression. ...Read more
Several: The mainstays of parkinsons treatment are Dopamine agonists such as Requip and the drug l-dopa (sinemet). Others include comtan, (entacapone) amantadine, selegeline, cogentin. Even ECT can be used in severe cases and there is also experimental surgery. Talk to your neurologist to see what is right for you or your loved one. ...Read more
Honestly, none...BUT: Diagnosis of Parkinson's by clinical means. Aka, with a good history & exam by an experienced neurologist or pcp. No lab abnormalities or even unique MRI changes are seen in pd. But, we do now have dat scan from ge healthcare. This nuclear medicine imaging study tells us simply yes or no, whether a patient has true degenerative Dopamine deficiency. So, it rules out mimicry of vs true parkinsonism. ...Read more
Slowly: Once the diagnosis is made, the initial problems can be handled with Dopamine agonists and seem stable for 1-2 yrs, but then the progression requires l-dopa, which may help nicely for about 6-8 yrs, during which time additional meds may be added. By 10-12 yrs the medications are sharply losing efficacy, and the next step may require use of a deep brain stimulator device. ...Read more