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Methotrexate cheaper: Generic Methotrexate is very inexpensive. If you get name brand pills it's more, but generic version of Arava (leflunomide) is more expensive than Methotrexate and Arava is the most expensive. In my experience, Methotrexate works better and has less frequent dosing (weekly instead of daily). I only use Leflunomide (arava) if Methotrexate can't be used for some reason. Side effects are similar. ...Read more
Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more
Dx:ra. Enbrel (etanercept) not effective after 6 mo. Humira 2x mo prescribed. Liver can not tolerate mtx. What medication can replace mtx to make humira work best?
Side effects: Usual side effects are stomach upset and rahshes. Occ headaches. Take the med at lower dose with food and if you can't tolerate tne maximum dose it may still be effective. Vision problems are very rare these s[ecialist and get an opthalmology referral quickly. ...Read moreSee 1 more doctor answer
On arava (leflunomide) 20mg, enbrel 50mg weekly, methotrexate 25mg. Any other rheumatologist prescribed this for psoriasis/psor. Arthitis?I'm worried about my liver.
Follow laboratory: You are correct that liver problems are risk with this regimen. Your physician needs to be certain that you are followed closely and correctly. Your own responsibility is to refrain from alcohol, and be certain no additional medicines you take do not worsen this risk. If you are concerned you need to discuss this with your physician. There are other therapy choices available. ...Read more
Yes.: No issue with both together.Get a more detailed answer ›
Yes: Cellcept (mycophenolate mofetil) is an immunosuppressant drug used to treat a variety if conditions. In rheumatology it is most commonly used to treat certain types of lupus. Cellcept (mycophenolate mofetil) has been used successfully to treat dermatomyositis. It can help lower and or eliminate the steroid dose. ...Read more
Plenty : XX oral dos: Methotrexate is a surprisingly effective drug for many forms of arthritis and the consensus 1st choice for RA by the acr and eular (european). The oral dosage is more problematic because of variable absorption and first-pass effect through liver. It is completely absorbed with sucutaneous injection and doesn't bolus liver. Hair loss can be a problem. Everyone should take 2mg of folic acid. ...Read more
Yes!: No issues!Get a more detailed answer ›
Is it safe to take Clenbuterol while using Imuran (azathioprine)? Taking Imuran (azathioprine) to treat chronic liver decease
Yes it is safe!: Not A PROBLEM!Get a more detailed answer ›
Drug interaction of humira (adalimumab) with niacin
can taking niacin affect the effectiveness of humira (adalimumab)?
No: Though interactions were reported in patients taking these two agents, Humira (adalimumab) and niacin, the patients were taking multiple other medications. It was not shown to be an interaction between the Niacin and humira (adalimumab). To test it individually, the Niacin could simply be stopped for a month assuming the Niacin was being used to treat hyperlipidemia. Ask your doctor if it is safe to hold the niacin. ...Read more
Mostly infusion rxns: Rituxan is given intravenously slowly at first to look for common immediate reactions like chills, fever, shakes, itching, hives, headache all of which could be prevented or lessened by giving premedications like Benadryl (diphenhydramine) and steroids. Reactivation of hepatitis b, lowering resistance to infections, rapid destruction of tumor cells causing i'll effects to organs (tumor lysis) can also occur. ...Read more
Watch for infections: Orencia (abatacept) is approved to treat moderate to severe rheumatoid arthritis. Typically it is prescribed when disease modifying anti rheumatic drugs (DMARDS) are not effective. The most common DMARD is methotrexate. Orencia (abatacept) is usually prescribed in combination with methotrexate but sometimes is given alone. Orencia (abatacept) is quite effective for many but not all people. It's main side effect: infections. ...Read moreSee 1 more doctor answer
Many: Methotrexate toxicity can take many forms, from extreme mucositis, low blood counts, and kidney damage. If Methotrexate is given intrathecally (into spinal csf) as is done to treat leukemia, it can sometimes cause toxicity to the brain, which can manifest itself as seizures. Methotrexate can also affect the liver and lungs. If you are having new symptoms, talk with the prescribing doctor. ...Read more
Standard therapy: Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA and other rheumatologist diseases. ...Read moreSee 2 more doctor answers
See details: What do you mean by sick? If you mean GI problems such as nausea and vomiting, it may last a few days. I would suggest that the Methotrexate be given by injection subcutaneously instead of by mouth. It is easy to do and will avoid GI issues. It may also be more effective this way. ...Read more
Many and quite safe!: Mtx is used in many autoimmune diseases with great effect. The drug is given IV in high doses to treat cancer. In much lower doses, given subcutaneously like insulin, with fewer side-effects than the same oral dose, does not go to the liver. And you absorb 100%, not the 40-90% when taken by mouth. Great drug. Ist line in ra! ...Read moreSee 1 more doctor answer
A mainstay for...: The treatment of rheumatoid arthritis and psoriatic arthritis, and other inflammatory conditions! i administer to my patients mtx by the subcutaneous route, thereby insuring 100% absorption and bypassing stomach and liver. When given with folic acid, i rarely see significant problems for my patients! ...Read moreSee 1 more doctor answer