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Doctor insights on: Diphenhydramine Vs Pseudoephedrine

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Is there a difference between Benadryl (diphenhydramine) and pseudoephedrine?

Is there a difference between Benadryl (diphenhydramine) and pseudoephedrine?

Benadryl (diphenhydramine) and Sudafed: Benadryl (diphenhydramine) is an antihistamine (blocks the histamine receptor) and sudafed is a decongestant. Basically sudafed grabs a hold of the blood vessels and squeezes them down for a period of time. Hence the reason that rebound congestion and high blood pressure are attributed to this medicine. ...Read more

Dr. John Chiu
1,047 Doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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Can you take pseudoephedrine with diphenhydramine?

Can you take pseudoephedrine with diphenhydramine?

Yes.: Psuedoephedrine is a sympathomimetic which may rev you up a bit. Diphenhydramine is an antihistamine (antiallergy) medication with some sedating properties as well. ...Read more

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Taking 120 mg pseudoephedrine every 12 hours, 10 mg loratadine in morning, and one Benadryl (diphenhydramine) at bedtime, is this ok?

Taking 120 mg pseudoephedrine every 12 hours, 10 mg loratadine in morning, and one Benadryl (diphenhydramine) at bedtime, is this ok?

Medication question: It is okay to take the pseudoephedrine with the loratadine. However, the nighttime Benadryl (diphenhydramine) would be considered a duplication of the loratadine which is a 24 hour medication. Without knowing more about your medical history, I would not suggest that you do that. Instead, I would suggest discussing the optimum management of your medications with your doctor. ...Read more

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What's the difference between Benadryl (diphenhydramine) and sudafed?

Medical questions: Benadryl (diphenhydramine) is an antihistamine, good for allergies and to lessen the drainage during an upper respiratory infection. Sudafed is a decongestant, good for helping you breath through a stuffy nose from a cold, bad allergies or sinus problems. Sudafed can also raise blood pressure, and shouldn't be taken on a regular basis. ...Read more

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Can you give a child Benadryl (diphenhydramine) and sudafed at the same time?

Can you give a child Benadryl (diphenhydramine) and sudafed at the same time?

Avoid decongestants: Pseudoephedrine (sudafed) can cause irritability and high blood pressure in children but doesn't seem to actually help with congestion until puberty. Sudafed-pe (phenylephrine) has the same issues but typically is very poorly absorbed into the body. These drugs should never be given to children given the potential harm and lack of benefit.
Benadryl should be limited to once a day during a cold. ...Read more

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What is the recommended doseage schedule when taking both Sudafed with Benadryl (diphenhydramine) together?

What is the recommended doseage schedule when taking both Sudafed with Benadryl (diphenhydramine) together?

Every 6 hours: It is OK to use both together. Do not use either one more than 4 times in a 24 hour period (every 6 hours). Of course, follow the directions on the box that indicates the number of pills (dosage) to take at one time. Sudafed is a decongestant and benadryl (diphenhydramine) is an antihistamine so they have two different effects. ...Read more

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I took regular sudafed a few hours ago. Can I take a Benadryl (diphenhydramine) before I go to bed?

Yes: Yes. Benadryl (diphenhydramine) ins an antihistamine, and sudafed is a decongestant. There is no problem taking them together at their recommended dosages, as long as you don't have any medical conditions in which these medications are not recommended (check with your doctor if you are unsure). ...Read more

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Can I take Benadryl (diphenhydramine) and sudafed while taking Wellbutrin?

Can I take Benadryl (diphenhydramine) and sudafed while taking Wellbutrin?

Not sudafed: It is okay to take benadryl (diphenhydramine) while taking Wellbutrin, although a less sedating anti-histamine such as Claritin or Zyrtec might be a better choice. Sudafed can result in increased heart rate and/or blood pressure, and these effects may be worsened while taking Wellbutrin. Try taking guafenesin in the form of Robitussin or Mucinex, it is very safe and may be very helpful for your congestion. ...Read more

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What happens when you take aspirin, benadryl, (diphenhydramine) sudafed and Mucinex all at the same time?

What happens when you take aspirin, benadryl, (diphenhydramine) sudafed and Mucinex all at the same time?

Nothing serious: Nothing serious iat 31 yrs age if there is no asthma or ulcer. Just dryness or fatigue can occur. ...Read more

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Just took Sudafed (nondrowsy small round red pill). I meant to take Benadryl (diphenhydramine) (pink oblong pill) for relief from an itchy rash. Can I stil take benadryl (diphenhydramine)?

Just took Sudafed (nondrowsy small round red pill). I meant to take Benadryl (diphenhydramine) (pink oblong pill) for relief from an itchy rash. Can I stil take benadryl (diphenhydramine)?

Yes you can: Plain sudafed doesn't contain an antihistaminic, just a decongestant, but mind you if have elevated blood pressure be cautious with decongestants in general including sudafed, good luck ...Read more

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Can u mix Claritin with Benadryl (diphenhydramine) & sudafed sinus headache?

Can u mix Claritin with Benadryl (diphenhydramine) & sudafed sinus headache?

Too many pills: Pne time ok, either claritine orbenadryl plus palin sudafed. See an allergist and or neurologist if headache cont. Good to find the cause. ...Read more

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I have VERY bad sinus problems. Is it okay to take Sudafed and Benadryl (diphenhydramine) together? I also take birth control and fluoxetine for prescriptions. Thanks!

I have VERY bad sinus problems. Is it okay to take Sudafed and Benadryl (diphenhydramine) together? I also take birth control and fluoxetine for prescriptions. Thanks!

Short term: You may take Sudafed and Benadryl (diphenhydramine) together for sinus congestion. The recommended dose of Sudafed in 30 mg three times a day for 5 days. You can take up to 50 mg of Benadryl (diphenhydramine) at a time, but it is likely to make you tired. There are no major interactions with your birth control and fluoxetine. As always, consult with your doctor if you have ongoing problems. ...Read more

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I have a horrible headache from sinus pressure I tried afrin nose spray and Benadryl (diphenhydramine) at night. I feel terrible? Would I benefit more from sudafed?

I have a horrible headache from sinus pressure I tried afrin nose spray and Benadryl (diphenhydramine) at night. I feel terrible? Would I benefit more from sudafed?

Maybe: It would be better to see some one for your problem. Afrin spray and benadryl (diphenhydramine) or not the best remedies for sinus complaints. Sudafed may help better, but you should see your physician to make sure that you are treating the right problem. ...Read more

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I had runny nose/congestion for 4 days, took Benadryl + Sudafed, runny nose gone now, but still need Sudafed at night to breathe. Should I be worried?

I had runny nose/congestion for 4 days, took Benadryl + Sudafed, runny nose gone now, but still need Sudafed at night to breathe. Should I be worried?

No: No, probably just a common cold, sometimes symptoms can last 10-14 days. Try not to use sudafed every night though. It is a decongestant and will work quickly to help you breathe, but can also cause side effects. Natural remedies like using a humidifier, nasal saline rinses, and drinking tea with honey before bed can help. ...Read more

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I currently take flonase, benadryl, sudafed PE, &zyrtec, yet my allergies are not controlled. Avoid food sensitivities/worse after URI. Y nt controlled?

I currently take flonase, benadryl, sudafed PE, &zyrtec, yet my allergies are not controlled. Avoid food sensitivities/worse after URI. Y nt controlled?

Allergy triggers: You might be a candidate for allergy desensitization shots. Are you able to avoid allergens? Make your bedroom as allergen free as possible. Here is an article from the American College of Allergy Asthma and Immunology:
http://acaai. Org/allergies/allergy-treatment/environmental-trigger-avoidance ...Read more

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Took 2 reactine e.s 24 hours ago. Safe to take 2 benadryl (diphenhydramine) now?

Yes: As long as you are aware that this may make you drowsy- perhaps that's what you want in the first place. ...Read more

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


Dr. Louis Vernacchio
404 Doctors shared insights

Pseudoephedrine (Definition)

Pseudoephedrine is a decongestant which is a kind of antihistamine type drug (common ...Read more