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Doctor insights on: Diphenhydramine Sedating Antihistamine

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Is loratadine like benadryl (diphenhydramine)?

Is loratadine like benadryl (diphenhydramine)?

Kinda mostly: Loratadine is a 'non-sedating antihistamine, ' and Diphenhydramine (/benadryl) is a sedating antihistamine (aka: older / h1 & h2 blocker), so yes, they are close cousins in intended effects--just differ in side effects. ...Read more

Dr. John Chiu
1,052 doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


Dr. Anlin Xu Dr. Xu
8 doctors agreed:
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Can Claritin (loratadine) non-drowsy antihistamine still cause drowsiness?

Dr. Anlin Xu Dr. Xu
8 doctors agreed:
Can Claritin (loratadine) non-drowsy antihistamine still cause drowsiness?

Yes: Claritin is a second generation antihistamine which causes much less drowsiness than first generation antihistamine, like benadryl (diphenhydramine). The number of people who feel drowsy on Claritin is so low that it is labeled "non-drowsy". But each of us is unique. I have plenty of patients who feel drowsy on claritin, especially petite women. ...Read more

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Is Claritin comparable to benadryl (diphenhydramine)?

Is Claritin comparable to benadryl (diphenhydramine)?

Both AH: Both act in similar fashion except that Benadryl (diphenhydramine) causes drowsiness and dry mouth in a much higher percentage of people and it works for just a few hours vs claritin's nearly 24 hours duration of action. ...Read more

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Cani take Benadryl (diphenhydramine) with loratadine?

Cani take Benadryl (diphenhydramine) with loratadine?

Probably yes.: Many people report their 'daily' non-sedating antihistamine in the am does not provide relief until next am. So, if no concerns for gu/heart/bp/med-conflict issues, then they often take a 'sedating' antihistamine at night for continued symptom relief and 'bonus' of sleep aid effect. ...Read more

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Benadryl (diphenhydramine) allergy make you sleepy?

Benadryl (diphenhydramine) allergy make you sleepy?

Yes It Can: Benedryl makes most people sleepy. Allergies make most people sleepy. So an allergy to benedryl should, you guessed it, can make you sleepy. ...Read more

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Is Claritin (loratadine) same as benedryl?

Is Claritin (loratadine) same as benedryl?

Not exactly: Benadryl (diphenhydramine) is diphenydramine, an old first generation antihistamines that lasts about 6 hours and can cause drowsiness and other side effects. Claritin (loratadine) is a new generation antihistamine that can last 24 hours and has less side effects. At this time, there is no real advantage to benadryl, (diphenhydramine) unless a person also wants some sleep.... ...Read more

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Zyrtec vs cetirizine?

Zyrtec vs cetirizine?

Same and different: Both one and same thing antihitamine once a day pill generic vs no generic, both over the counter. Should be taken at night as it can make you sleepy. Try not to take every day every pill has side effects. ...Read more

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Claritin versus Benadryl (diphenhydramine) for kids?

Claritin versus Benadryl (diphenhydramine) for kids?

Work differently: Claritin in a non-drowsy antihistamine. It doesn't cause sleepiness, but you need to use it every day for it to work really well. It's lousy for severe allergic reactions because it takes days to be fully effective. Benadryl (diphenhydramine) causes drowsiness and only lasts for six hours, but is great for severe allergic reactions and works very quickly. If you're exposed and need help now, Benadryl (diphenhydramine) is better. ...Read more

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Is zyrtec or polaramine (dexchlorpheniramine maleate) stronger?

Is zyrtec or polaramine (dexchlorpheniramine maleate) stronger?

Zyrtec (cetirizine): Polaramine (dexchlorpheniramine maleate) (dexchlorpheniramine) is an older antihistamine that is not used as often due to dosing every 8 hours and side effects (impaired driving ability). Effectiveness of polaramine (dexchlorpheniramine maleate) was similar to Claritin (loratadine) while a study in healthy adults showed zyrtec (cetirizine) to be a better antihistamine than polaramine (dexchlorpheniramine maleate). Go to: http://www.Ncbi.Nlm.Nih.Gov/pubmed/2972549. ...Read more

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Claritin for children and Benadryl (diphenhydramine) together?

Not recommended: Both Claritin and Benadryl (diphenhydramine) are anti histamines. Claritin is long acting usually used once a day and Benadryl (diphenhydramine) is shorter acting. May be used 3-4 times a day. Since they both have action, recommended not to take it same time. ...Read more

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Which is best zyrtec allegra (fexofenadine) claranex?

Which is best zyrtec allegra (fexofenadine) claranex?

Depends: All 3 of the mentioned new generation antihistamines (zyrtec, allegra, (fexofenadine) clarinex) are effective for treating allergic rhinitis and hives. What's interesting is that each individual person may respond better to one over the other. While every allergist probably has his/her favorite, truth is...They all work. If not happy with one, try a different one! ...Read more

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Itching , no rash, tried zyrtec, valium, vistaril (hydroxyzine)?

Itching , no rash, tried zyrtec,  valium, vistaril (hydroxyzine)?

Itching: You probably need to see an allergist to identify the cause of the itch. Sometimes it can be an allergy or a skin condition or an immune problem. Some tests are warranted at your age to find the problem. ...Read more

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Is taking Benadryl (diphenhydramine) with codeine safe?

Is taking Benadryl (diphenhydramine) with codeine safe?

Benadryl (diphenhydramine) & Codeine: Hello. Benadryl (diphenhydramine) and codeine taken together could make you sleepy so please make sure that you are not driving, operating equipment, or involved in any activities which require your cognition to be 100% on point! Are you taking Benadryl (diphenhydramine) to counteract itching from codeine? If so, you may need to talk to your provider about trying something different. ...Read more

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Does Claritin work better than benadryl (diphenhydramine)?

Not necessarily: Claritin is non-sedating at 10 mg and is a once daily medication. It has an onset of action approximately 30 minutes after taking. Benadryl (diphenhydramine) tends to work more quickly but lasts only 4-6 hours and can be sedating. ...Read more

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


Dr. Paul Carter
649 doctors shared insights

Antihistamine (Definition)

Sedating and non-sedating antihistamines prevent and treat allergic reactions, and are ...Read more