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Doctor insights on: Diphenhydramine Liver

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Can an od of 1600mg to 3200mg on diphenhydramine effect the liver or any other organs?

Can an od of 1600mg to 3200mg on diphenhydramine effect the liver or any other organs?

See a doctor now!: Dphm (aka benadryl): "severe" symptoms occur at the critical dose limit of 1 gram=1000mg. Although the frequency of delirium/psychosis, coma and seizures can occur. "moderate" symptoms (300mg or more) include isolated & spontaneously resolving agitation, confusion, hallucinations & ekg abnormalities. It is metabolized via cytochrome p450 2d6 isoenzyme in the liver.

Dr. Harinder Gill
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Liver (Definition)

This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more


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I take benadryl (diphenhydramine) everyday about 250mg not at once but during the day for chonic allergies. Been doing this for two years will this damage my liver?

I take benadryl (diphenhydramine) everyday about 250mg not at once but during the day for chonic allergies. Been doing this for two years will this damage my liver?

No, but...: That is really a lot of benadryl (diphenhydramine) and while it will not damage your liver it can have a lot of side effects such as fatigue, dry mouth, constipation and mental slowing. Discuss a change to a non-sedating antihistamine, nasal saline and some nasal steroids with your doctor and try to get off this large dose of benadryl (diphenhydramine). Singulair may also be helpful.

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I currently take around 200 Mg of Benedryl (diphenhydramine 25Mg x 8) every night to sleep. I'm worried about addiction and liver damage?

I currently take around 200 Mg of Benedryl (diphenhydramine 25Mg x 8) every night to sleep. I'm worried about addiction and liver damage?

Benedryl Dependence: Taking 200 Mg of Benedryl every night to sleep indicates Dependence or Addiction. There is risk of liver damage if Benadryl Tylenol (acetaminophen) in it. Let Wise Woman within you reflect: • Stresses causing Anxiety and Depression leading to Insomnia Consider: • Therapy and medication by Psychiatrist • Realize and feel Wonder of Breath of Life. • Become Captain over Stresses of Life and Insomnia, Not Victim.

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Accidentally give my liver too much? Had 1/4 glass of wine. Then 3 hrs later, not thinking, took a Benadryl (diphenhydramine) for allerg and 25 mg of prs Zoloft for anx

Accidentally give my liver too much? Had 1/4 glass of wine. Then 3 hrs later, not thinking, took a Benadryl (diphenhydramine) for allerg and 25 mg of prs Zoloft for anx

Liver likely ok: Although alcohol, Benadryl (diphenhydramine), and Zoloft (sertraline) are all broken down by the liver, the quantities you mention shouldn't be a problem for an otherwise healthy liver. But I'm a little concerned if you take Zoloft "prn" (as needed) for anxiety. It doesn't work well that way, although it can relieve anxiety if taken daily. Talk to your prescribing doctor about this.

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I have liver disease from overdosing on Tylenol (acetaminophen) (not treated) benadryl and xanax in teen years, how is this treated/managed?

I have liver disease from overdosing on Tylenol (acetaminophen) (not treated) benadryl and xanax in teen years, how is this treated/managed?

More informaton: There are blood tests that can indicate liver damage. This information would be needed. Benadryl and Xanax would be unlikely to contribute to liver damage. Tylenol (acetaminophen) might, but it would depend on the dose. You need medical verification of liver damage; and then the question of treatment can be addressed.

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I have a question about Diphenhydramines?

I have a question about Diphenhydramines?

Ask away: If you have a question about diphenhydramines, this site would be a good place to find the answer. Your next step would be to ask the question.

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Is 150 mg of diphenhydramine okay?

Too much: This is too much diphenhydramine, you should not take such high doses before checking with a doctor or guided by a doctor.

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Is 75mg of diphenhydramine an overdose?

75mg diphenhydramine: Is larger than a single dose should be for an adult or child. So it is technically an overdose. Normal doses for a child may be 75 to 150mg per day in divided dose or 150 to 300 mg per day in a divided dose for an adult. Are you considering taking an overdose? If you are -please have a friend or relative take you to the nearest er or call 911. With help your life and problems can improve.

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Is taking 300mg of diphenhydramine bad for you?

Probably: You may need up with very dry mouth, drowsiness, constipation, and even a fast heart rate from such a high dose.

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Is diphenhydramine hc1 50 addictive?

Is diphenhydramine hc1 50 addictive?

No: Diphenhydramine helps restless and anxiety through it's antihistamine activity, much like vistaril (hydroxyzine). It is not addictive, but if you are taking it several times daily you could find yourself having some withdrawal symptoms like runny nose.

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What is Benadryl (diphenhydramine) used for?

What is Benadryl (diphenhydramine) used for?

See below: Benadryl (diphenhydramine) is an antihistamine. It is normally used to help with allergy symptoms, sneezing, and runny nose. It can also help with itchy rashes. Also, it is occasionally used for motion sickness.

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What is diphenhydromebe citrate vs diphenhydramine hci?

What is diphenhydromebe citrate vs diphenhydramine hci?

Similar: Just different "salts" with the same active ingredient.

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Is there a health risk if I keep abusing diphenhydramine?

Please define abuse: How much and how often do you take it?

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How should a person feel if the snorted 50 mgs of benadryl (diphenhydramine)?

Bad idea: The snorting of medicines that are not supposed to be administered intranasally is usually going to lead to catastrophic effects. The consequences of administering Benadryl (diphenhydramine) in an inappropriate manner could be delirium and hallucinations. You could also turn psychotic and accidentally hurt yourself or someone else.

Dr. John Chiu
1,046 Doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more