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Doctor insights on: Diphenhydramine Interactions

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Are there any interactions between diphenhydramine and l-theamine? Can both be taken together safely in recommended amounts for sleep?

Are there any interactions between diphenhydramine and l-theamine? Can both be taken together safely in recommended amounts for sleep?

No: I am not sure what l-theanine is. However, the only dietary supplements/herbals i know of which should be avoided when taking Diphenhydramine are valerian, st. John's wort, kava kava, and gotu kola; as the combination may enhance CNS depression. I am doubtful that whatever l-theanine is will compound any sedative effects you may experience with Diphenhydramine alone. ...Read more

Dr. John Chiu
1,011 doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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Will over-the-counter antihistamines like Benadryl (diphenhydramine) have any bad interactions with ssris like zoloft?

Will over-the-counter antihistamines like Benadryl (diphenhydramine) have any bad interactions with ssris like zoloft?

Generally no: Second generation antihistamines such as allegra, zyrtec and Claritin are non sedating and do not interact with ssris. Benadryl (diphenhydramine) is sedating and may increase the sedation of ssris. ...Read more

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Is it safe to take Pseudophedrine and Diphenhydramine together? Medscape says significant interaction but other sources say no interaction.

Is it safe to take Pseudophedrine and Diphenhydramine together? Medscape says significant interaction but other sources say no interaction.

OK to take together: Diphenhydramine is benadryl, (diphenhydramine) which is an antihistamine. Many antihistamines are taken together with decongestants such as pseudoephedrine. Diphenhydramine can help itching, sneezing, swelling, whereas Pseudoephedrine can help nasal congestion. Common antihistamine/decongestant combos include loratadine-D, cetirizine-D, fenofexadine-D. ...Read more

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Are there any drug interaction with inderal (propranolol) and diphenhydramine?

Are there any drug interaction with inderal (propranolol) and diphenhydramine?

No: There are no significant interactions between these two drugs. They are safe to take together. ...Read more

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Interaction between Synthroid (thyroxine) and sleep-eze (diphenhydramine hydrochloride) ?

No significant: Medication interactions were noted when using a drug interaction checker. But that is never a 100% guarantee. ...Read more

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more