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Doctor insights on: Diphenhydramine Interactions

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Are there any interactions between diphenhydramine and l-theamine? Can both be taken together safely in recommended amounts for sleep?

Are there any interactions between diphenhydramine and l-theamine? Can both be taken together safely in recommended amounts for sleep?

No: I am not sure what l-theanine is. However, the only dietary supplements/herbals I know of which should be avoided when taking Diphenhydramine are valerian, st. John's wort, kava kava, and gotu kola; as the combination may enhance CNS depression. I am doubtful that whatever l-theanine is will compound any sedative effects you may experience with Diphenhydramine alone.

Dr. John Chiu
1,046 Doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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Will over-the-counter antihistamines like Benadryl (diphenhydramine) have any bad interactions with ssris like zoloft?

Will over-the-counter antihistamines like Benadryl (diphenhydramine) have any bad interactions with ssris like zoloft?

Generally no: Second generation antihistamines such as allegra, zyrtec and Claritin are non sedating and do not interact with ssris. Benadryl (diphenhydramine) is sedating and may increase the sedation of ssris.

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Is it safe to take Pseudophedrine and Diphenhydramine together? Medscape says significant interaction but other sources say no interaction.

Is it safe to take Pseudophedrine and Diphenhydramine together? Medscape says significant interaction but other sources say no interaction.

OK to take together: Diphenhydramine is benadryl, (diphenhydramine) which is an antihistamine. Many antihistamines are taken together with decongestants such as pseudoephedrine. Diphenhydramine can help itching, sneezing, swelling, whereas Pseudoephedrine can help nasal congestion. Common antihistamine/decongestant combos include loratadine-D, cetirizine-D, fenofexadine-D.

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Are there any drug interaction with inderal (propranolol) and diphenhydramine?

Are there any drug interaction with inderal (propranolol) and diphenhydramine?

No: There are no significant interactions between these two drugs. They are safe to take together.

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Interaction between Synthroid (thyroxine) and sleep-eze (diphenhydramine hydrochloride)?

No significant: Medication interactions were noted when using a drug interaction checker. But that is never a 100% guarantee.

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Is it ok to take 10mg of Claritin and one Benadryl (diphenhydramine) with lisinopril? Is there any interaction between Lisinopril and Benedryl?

OK and No: Fine to take one benadryl (diphenhydramine) if you already had claritin, but don't do it often unless guided by a physician. No interaction between lisinopril and benadryl (diphenhydramine)

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How common is a diphenhydramine symptomatic overdose in the u.S.?

How common is a diphenhydramine symptomatic overdose in the u.S.?

Toxicity: Every human body reacts to a drug differently. In some children, even one dose of Benadryl (diphenhydramine) will make them very hyper (known as a paradoxical reaction). First and foremost, you should always follow the labeled instructions on all otc medications. If still unsure, speak to your physician. Otc med overdoses are fairly common in the usa.

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I have a question about Diphenhydramines?

I have a question about Diphenhydramines?

Ask away: If you have a question about diphenhydramines, this site would be a good place to find the answer. Your next step would be to ask the question.

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Is diphenhydramine adictave?

Is diphenhydramine adictave?

No: The antihistamine is does not have addictive qualities. Yet a person can become habit driven to continue any product/medication/coffee/food etc. Habituation is a strong force in ones life to continue past patterns. If stopped, a longing for that product can be quite strong, but it does not produce the physical addiction entails.

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Can I cut diphenhydramine in half?

Can I cut diphenhydramine in half?

Depends: Some Diphenhydramine comes in capsules and some in solid pills. You can cut the pills but the capsules will just squish, break open and spill the contents. If capsules are all you have, you can dissolve the contents in water and drink half or something we do with patients at times is to mix it with jello and have them eat the proper amount.

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Is 150 mg of diphenhydramine okay?

Is 150 mg of diphenhydramine okay?

Too much: This is too much diphenhydramine, you should not take such high doses before checking with a doctor or guided by a doctor.

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Can I cut a diphenhydramine in half?

Can I cut a diphenhydramine in half?

Tabs, yes: It is not practical to cut a capsule, but a scored tablet can be easily cut with a pill cutter. There are many formulations of Diphenhydramine in case a lower than usual dose is required.

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What color are diphenhydramine pills?

DiphenhydramineColor: Usually they are pink or pink and white if capsules; but I do not know if soem generic version scould be white.

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Can I take 75mg of Diphenhydramine HCI?

Probably but why?: Adult dosing is 25-50 mg every 4-6 hours as needed. Maximum dosing is listed as 100mg per dose up to a total of 300 to 400mg per day. I'm just wondering your reason for taking 75mg, as this medicine is sedating, and can make you sleepy. If the 25-50 mg isn't strong enough, maybe there's something else better for you to try. Discuss this with your doctor, who might have a better suggestion for you.

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Is 75mg of diphenhydramine an overdose?

75mg diphenhydramine: Is larger than a single dose should be for an adult or child. So it is technically an overdose. Normal doses for a child may be 75 to 150mg per day in divided dose or 150 to 300 mg per day in a divided dose for an adult. Are you considering taking an overdose? If you are -please have a friend or relative take you to the nearest er or call 911. With help your life and problems can improve.

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What amount diphenhydramine is an overdose?

It depends: Diphenhydramine was a major cause of seizures reported to a poison center. At a dose of 7.5mg/Kg (a total dose of 500 mg [20 OTC tablets] for a 150 pound person) many p0eople will develop severe reactions. In doses over 1g (40 tablets) the drug may be lethal.

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Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more