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Doctor insights on: Diphenhydramine Hydrochloride Antihistamine

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I take 20mg of cetrizine hydrochloride (reactine brand) every morning.... I then took a couple hours later a 25mg benadryl (diphenhydramine) for a mild skin itch and di?

I take 20mg of cetrizine hydrochloride (reactine brand) every morning.... I then took a couple hours later a 25mg benadryl (diphenhydramine) for a mild skin itch and di?

Combination antihist: It is not clear that combining antihistamines produce better results. The only guarantee is usually more side effects. Cetirizine is effective at 10mg but works better at 20mg daily (split dose). If you give more it doesn't work a lot better but you do see more sedation. Diphenhydramine is more sedating at ANY dose compared to drugs like cetirizine loratadine fexofenadine. ...Read more

Dr. John Chiu
1,011 doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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What are long term side effects of diphenhydramine antihistamines and do they lose effectiveness over time? K

What are long term side effects of diphenhydramine antihistamines and do they lose effectiveness over time?
K

Minimal: Diphenhydramine is the active ingredient in Benadryl (diphenhydramine) and has been around for a very long time. Like most antihistamines, there is not believed to be long term side effects. Losing effectiveness is less well studied, but with ongoing use there could be some development of tolerance or it could be that you are still being exposed to an allergen and that is why symptoms are not controlled. ...Read more

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Can I take Benadryl (diphenhydramine) with another antihistamine? Thanks in advance.

Not recommended.: 2 antihistamines together will probably exacerbate negative side effects without necessarily increasing the positive effect of the medication. Not recommended. ...Read more

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What amount of does take to get high off of diphenhydramine hci/antihistamine and how long does it take to kick in?

What amount of does take to get high off of diphenhydramine hci/antihistamine and how long does it take to kick in?

Varies: Varies with dose. Some people get sleepy at lower dose than others. Some people get jumpy instead, especially children. Also depends on interaction with other meds or alcohol or caffeine. ...Read more

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Is there any other antihistamines that have as strong of or stronger anti allergic properties than benadryl (diphenhydramine)?

Antihistamines: Yes. There are a number of them. Many available only by prescription. Different ones have different side effects. See your doctor to discuss which would be best for you. ...Read more

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Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


Dr. Paul Carter
601 doctors shared insights

Antihistamine (Definition)

Sedating and non-sedating antihistamines prevent and treat allergic reactions, and are ...Read more