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Doctor insights on: Diphenhydramine H Cl Overdose

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Dr. John Chiu
1,047 doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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How much diphenhydramine HCl will kill me?

How much diphenhydramine HCl will kill me?

Tons: You will likely be able to tolerate at least 5 capsules without much problem except for drowsiness and a dry mouth. As for the lethal dose, I don't know the exact number but I'd doubt that even taking 20 capsules can kill you. ...Read more

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Are fexofenadine HCl and diphenhydramine HCl the same?

Are fexofenadine HCl and diphenhydramine HCl the same?

No: Benadryl (diphenhydramine) is a short-acting antihistamine and is more likely to make you sleepy when used. Fexofenadine is a second-generation, non-sedating antihistamine which should have more lasting effects, closer to 24 hours, and is less likely to make you sleepy. ...Read more

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What should I take diphenhydramine HCl 25mg or diphenhydramine citrate 38mg?

What For?: More info is needed to decide proper dose and if this is the medicine for whatever the problem is. ...Read more

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I've been taking about 500 to 1400mg of OTC diphenhydramine hcl daily for about the last 6-8 years and have stopped. How can I stop the ITCHING!!?

I've been taking about 500 to 1400mg of OTC diphenhydramine hcl daily for about the last 6-8 years and have stopped. How can I stop the ITCHING!!?

Find out the cause: Consider consulting a dermatologist if the itching has been going on for 6-8 years. A dermatologist can help you sort out the cause or devise a treatment program which can help control the itching. On the other hand, if high doses of antihistamine controls the itching without side effects for several years, you may continue taking it. ...Read more

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Been taking diphenhydramine HCL for about 10 years in high doses. I have recently stopped taking them. The itching is intense. HOW CAN I STOP THE ITCH?

Been taking diphenhydramine HCL for about 10 years in high doses. I have recently stopped taking them. The itching is intense. HOW CAN I STOP THE ITCH?

Why did u stop?: U could try the "non-sedating" antihistamines like Allegra, (fexofenadine)Zyrtec, Xyzal, or see an Allergist/Immunologist. They have other meds in the fight against chronic pruritis. Good luck ...Read more

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Is it okay to take a diphenhydramine HCl with my zanaflex (tizanidine)?

It is OK: there are no interactions between zanaflex (tizanidine) and diphenhydramine. However, always before beginning any new drug, it is important to review your medical history with your doctor. ...Read more

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I'm taking diclofenac sod ec 75mg.can I take sleep med that has only diphenhydramine HCl 25 mg?

I'm taking diclofenac sod ec 75mg.can I take sleep med that has only diphenhydramine HCl 25 mg?

Yes: These medicines have different mechanism of action and that is not a problem. Discuss this with your physician if there's any other medical issues we are not aware of. ...Read more

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What are the dosage differences in diphenhydramine HCl and citrate if I take 50mg of HCl for sleep would I take 76 mg of citrate?

What are the dosage differences in diphenhydramine HCl and citrate if I take 50mg of HCl for sleep would I take 76 mg of citrate?

Not really different: There really is no significant therapeutic difference between the two forms of diphenhydramine, which will work well for sleep in either dose. ...Read more

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What side effects come from taking 1000mg of diphenhydramine HCL daily for 8 years? And how can I stop the itching after I've stopped taking them?

What side effects come from taking 1000mg of diphenhydramine HCL daily for 8 years? And how can I stop the itching after I've stopped taking them?

You need help: I hope you meant 100mg. If you're really taking 40 capsules of Benadryl (diphenhydramine) a day, and even if you're only taking 4 capsules a day, you need to see a board certified allergist for help. Even if the underlying cause of the itching can't be found, there are better ways to control it ...Read more

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150 mg Diphenhydramine hcl (3 Unisom Sleepgels) hasn't helped me sleep. Is it safe to bump it up to 200 mg?

150 mg Diphenhydramine hcl (3 Unisom Sleepgels) hasn't helped me sleep. Is it safe to bump it up to 200 mg?

Won't advise it: It will not kill you but may cause other side effects yet unlikely to help you to fall asleep by taking another 50 mg. ...Read more

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Mixing diphenhydramine HCL (50mg) with oxycodone (30mg)? Due to an accident, chronic, severe, pain does not let me sleep.......

Mixing diphenhydramine HCL (50mg) with oxycodone (30mg)? Due to an accident, chronic, severe, pain does not let me sleep.......

Consult doctor: It appears that you need pain management. Diphenhydramine has some sedating effect but does not work on everyone and certainly won't overcome the pain which may be keeping you awake. You need to address the cause and consulting a pain-management doctor may be worthwhile. ...Read more

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


Overdose (Definition)

When the maximum dose of medication ...Read more