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Doctor insights on: Diphenhydramine Drug Test

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Dr. Alan Wartenberg
570 doctors shared insights

Drug Testing (Definition)

It is the process of examining body fluids or tissue for evidence of chemicals taken or not taken. It does not diagnose addiction however this a ...Read more


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Is there a home drug test to test for diphenhydramine o.t.c. abuse? i suspect my husband is abusing it

Is there a home drug test to test for diphenhydramine o.t.c. abuse?  i suspect my husband is abusing it

Very doubtful: There's info here: https://en.wikipedia.org/wiki/Diphenhydramine But, I'm concerned too about your relationship. Suspicion is often as harmful as the behavior in question. Consider Couple's Therapy after a few prep sessions for you alone to learn how to communicate concern w/o blame. A test would do nothing to help resolve any problem. Best wishes 2U2. ...Read more

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I took drug test today and it was positive for tca, I regularly take an OTC sleep aid with diphenhydramine. Couldn't have caused the false positive?

I took drug test today and it was positive for tca, I regularly take an OTC sleep aid with diphenhydramine. Couldn't have caused the false positive?

"tca"????: did you mean THC (marijuana or cannabis)? TCA medically usually means tricyclic antidepressant, and these are actually chemically similar to benadryl (diphenhydramine). If all that was done was a SCREENING test, there are lots of potential false positives, and if used for legal purposes, all screening tests should be confirmed with a more sophisticated test, usually gas chromatography/mass spectroscopy. ...Read more

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Im on drug court and i want to take a sleep aid because i can't sleep I have a generic sleep aid but it has diphenhydramine hci in it will this make me test positive for anything or will it be ok to take it

Im on drug court and i want to take a sleep aid because i can't sleep I have a generic sleep aid but it has diphenhydramine hci in it will this make me test positive for anything or will it be ok to take it

The : The answer dr. Johnson provided is correct. There are reports that with very high doses, Diphenhydramine has in rare cases, led to false positive drug screening for benzodiazapines. However, if this were to occur, normally the sample would be retested using a more precise test and that would clear up the confusion. It is reported that it could also trigger a false positive for pcp (but this is also very rare). Diphenhydramine is not a good choice for chronic problems with sleep. If you are in a program that requires drug testing, you might consider skipping the Diphenhydramine and working on sleep hygiene first. ...Read more

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What is a non-dot drug test ?

What is a non-dot drug test ?

NonDept of Transport: A DOT drug test is a drug test the Department of Transportation (DOT) requires for businesses in the business of transportation. Businesses not regulated by the DOT can pick and choose which substances they check for (a non-DOT drug test). ...Read more

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In which situations must i take a drug test?

"must take?": Outside of criminal justice issues (people on probation or parole), there aren't any times where you must take the test. Some employers require drug testing before hiring, or while employed either on a random basis or if there are work-related problems, but you have the choice of working there or not. Drug testing is sometimes done in schools as well, or for child protective services etc. ...Read more

Dr. John Chiu
1,038 doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more