Doctor insights on:
Many genes: The previous answer is right with several genes associated with lupus, but no one knows how those genes cause disease. I think it's important to remember that there is likely many ways to develop lupus symptoms, and this will vary between people. So some of these known genes will be important for some, and not important for others. As we sequence more patients, we'll have more answers. ...Read moreSee 1 more doctor answer
Mysterious lupus: It is not known what causes lupus erythematosus. Referring to antiquity, lupus was used to describe several different rashes. It could be autoimmune, where the body attacks itself such as lupus erythematosus or discoid lupus. It could be caused by tuberculosis infection such as lupus vulgaris. It could be related to another inflammatory disease such as sarcoidosis which causes lupus pernio. ...Read more
Not always: Unfortunately, there is no single laboratory test that absolutely rules in or out systemic lupus erythematosis (sle). Although a highly positive antinuclear antigen (ANA) is common in sle, diagnosis is based on a careful history, physical exam and laboratory evaluation. ...Read moreSee 1 more doctor answer
What do you think?
Ana-positive, titer >1:640, speckled/ana titer 2-1:32, ANA pattern 2-homogeneous
c3 180.8, rnpab, IgG 1.5, CRP 1.9.
Possible MCTD: The highly positive ANA in a speckled pattern suggests mixed connective tissue disease. Mctd is a close cousin of lupus but usually has a better prognosis. The anti-rnp is usually be elevated in mctd. Interpreting the results of autoantibody studies can confusing. You should discuss these findings with a rheumatologist. ...Read more
Depends on biopsy: There are different grades of lupus nephritis based on the kidney biopsy. The more benign grades don't necessarily warrant any treatment but will needclose follow-up. The more severe forms (grade 4) require aggressive treatment with drugs to suppress the immune system since they may lead to kidney failure if left unchecked. If present, patients will also be treated for high blood pressure. ...Read more
ANA 250 -Indirect Immunofluoresence Assay with both speckled pattern, elevated ESR, rash with lesions on chest, neck,ears,face - LUPUS ?
Talk to doctor: Although these findings are not incompatible with lupus, the lack of joint symptoms points away from the diagnosis. The diagnosis of nearly all diseases should be made by a doctor and not by lab tests alone. ...Read more
Ana screen positive, ANA titer 320, rash very often on face, nucleolar pattern. Any significance?
Seizures mouth ulcers hepatocellular disease low blood count anticardiolipin antibodies 1:80 speckled ANA osteoarthritis spine Si joints LUPUS maybe?
Ana direct positive ANA , ifa neg , rnp 2.3, CRP 5.4 ss-b2.7.Diag with lupus connective tissue and sjorgen all at once? Why 2 ANA tests different answ
They can change!: Appears you have mctd with sjogren's like features based on the labs and titers. No lupus marker present! ...Read more
Diagnosed w/ lupus. Malar rash,photosenstvty,sicca ,mouth/nose sores,Recurring flares,leukopenia, ANA 1:640.All other labs neg.Possible w/normal labs?
Absolutely: Your general labs can be totally normal and you can still have lupus. ...Read more
Presented w/ inability to walk, joint/muscle pain, hairloss, positive ana, high ssdna, dsdna, ssa (ro), histone, sed rate, could this be lupus?
Yes: It certainly could be lupus. See a rheumatologist as soon as possible. ...Read more
I have positive ANA sm, ssa (ro), ssb (la) , ro52, jo-1, sci-70, ribosomal p antibodies what are the levels for each antibody that signify lupus ?
Level not important: If these antibodies are truly positive the degree of positivity is not that important. ...Read more
I have positive ANA sm, ssa (ro), ssb (la) , ro52, jo-1, sci-70, ribosomal p antibodies what are the levels for each antibody that signify lupus?
Levels not important: If the antibodies are positive, they are positive. The degree of positivity does not matter. ...Read more