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Doctor insights on: Dill Rf277 Ige

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Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

False positive rate: There is 30% or so false positive rate of kappa/lambda ratio in people without MGUS, myeloma or other disorders. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6) what are implications?

Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen  ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6)  what are implications?

Nothing.: Ebv antibodies indicate you had a previous infection, but not active. The c-reactive protein needs a units indicator - that is either normal or somewhat elevated. The anti ss dna is extremely nonspecific and very rarely indicated; I have no idea why that was ordered, discuss with your doctor. ...Read more

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Kappa/lambda FLC ratio high (2.75) w/ normal K(10.21mg/dl) & low L(3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow

Kappa/lambda FLC ratio high (2.75) w/ normal K(10.21mg/dl) & low L(3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow

Useless test: K/L ratio is not a useful test. About one third of patients without monoclonal immunoglboulin have an abnormal ratio, usually with kappa excess. If you must, the next step would be a bone marrow examination. You may consult this article that I wrote: https://www.ncbi.nlm.nih.gov/pubmed/27473738 At your age you are unlikely to have myeloma. ...Read more

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Immunofixation, Serum FAH = Monoclonal IgG kappa immunoglobulin. Beta FAH = 10.5% Abnormal band, immunofixation to follow. I'm IgA deficient too. ??

Immunofixation, Serum FAH = Monoclonal IgG kappa immunoglobulin.   Beta FAH = 10.5% Abnormal band, immunofixation to follow. I'm IgA deficient too. ??

Possibly: If I am understaning this right you have a monoclonal protien band? The most important next steps here would be to identify the band (immunofixation) and then perfrom quantitvaive immunoglobulin levels. IF there is a monoclonal band, you may very well have reciprocal depriciation of alternative immunoglobulins and IgA deficiecny with an IgG monoclonal protein is possible. ...Read more

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Is this Early RA? RA Latex Turbid .....<10 C-Reactive Protein Quant......2.4 CCP Antibodies 48 Sedimentation Rate 4 Platelet ..399 Creatine 1.04

Is this Early RA?
RA Latex Turbid .....<10 
C-Reactive Protein Quant......2.4 
CCP Antibodies  48 
Sedimentation Rate 4 
Platelet ..399
Creatine 1.04

See rheumatologist: I presume that you have some joint symptoms and thus the tests were obtained. However the diagnosed of RA is based on clinical findings supported by lab study and there is another test more specific than RA factor. Consult a rheumatologist. ...Read more

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Increased aldolase, complement c3/c4 serum, sed rate, c-react. Protein, beta globulin, monocytes, bun/creatin low mcv-mch, vit d-possible causes?

Increased aldolase,  complement c3/c4 serum, sed rate, c-react. Protein, beta globulin, monocytes, bun/creatin low mcv-mch, vit d-possible causes?

Complicated: When i was doing clinical medicine, these were collectively sort of the flags for sarcoid disease but I am not saying that's the case here. This is because sarcoid is a diagnosis of exclusion so the advice is to rule out other diseases with additional diagnostic tests which can be done by a primary care physician or rheumatologist. ...Read more

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Thyroid Peroxidase Antibodies 274.0 Anti-Thyroglobulin Antibody 164.4 Mean Platelet Volume 9.1 Erythrocyte Sed Rate 26 Estimat Glomerular Filtratio 43?

Thyroid Peroxidase Antibodies 274.0
Anti-Thyroglobulin Antibody 164.4
Mean Platelet Volume 9.1
Erythrocyte Sed Rate 26
Estimat Glomerular Filtratio 43?

Thyroid and kidneys: Hi. You have antibody evidence of thyroid autoimmunity. It would be nice to know your TSH and free T4. Are you on thyroid hormone? You have diminished kidney function. Do you know why? ...Read more

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My february blood tests showed ANA 1:80, rnp positive, CRP 5.1, TSH 1.83 also sed rate 25, mpv 12.1 what does this mean?

My february blood tests showed ANA 1:80, rnp positive, CRP 5.1, TSH 1.83 also sed rate 25, mpv 12.1  what does this mean?

Just a screening: An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood. ...Read more

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Protein Total Serum 8.7 Globulin Serum 4.20 Albumin/ Globulin Ratio 1.07 ALP 132 Urea/ CreatinineRatio 18.54 rest normal . Any worries here ?

 
Protein Total  Serum  8.7
Globulin Serum 4.20
Albumin/ Globulin Ratio 1.07
ALP  132
Urea/ CreatinineRatio 18.54
rest normal . Any worries here ?

Need more info.: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, there is no immediate concern, however, your globulin level may be higher than normal and you should discuss it with the doctor who ordered the tests. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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Gamma Globulin 1.8 slightly high The rest normal. No M-protein spike. IGE Serum 151 H IgG 1768 H What could cause these results...

Gamma Globulin 1.8 slightly high
The rest normal.
No M-protein  spike.
IGE Serum 151 H
IgG 1768 H 
What could cause these results...

Reassurance : You just have very high immunity. All this number show a very good defense mechanism. Sometimes the questions is: from what? May be your doctor can answer that question. ...Read more

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Glucose serum112 mg/dL,T3 (liothyronine) free 2.5 pg/ml,T4 free 1.14 ng/dl,TSH 2.180 uIU/ml-blood test taken PM-no fasting/no meds told have hypothyroidism-confused?

Taking thyroid med?: Hi. Those thyroid function tests are normal. If you're not taking thyroid hormone, then you're not hypothyroid. I'm sorry for the confusion; no one should have told you you're hypothyroid based on those labs. I would advise against taking desiccated porcine thyroid (Armour). See an endocrinologist if you want expert opinion on thyroid issues; many excellent ones in your area. Your thyroid's normal ...Read more

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LP Done. Monocytes 1%, Serum IgG 587/mg/DL,Albumin 4100ml,IGG Index 1.1mg,WBC 23/mm3,RBC 1/mm3, CSF IGG 3.6 mg/DL,Lymphocytoid 97%, protein, neutrophils, glucose, CSF albumin all norm. Any ideas?

LP Done. Monocytes 1%, Serum IgG 587/mg/DL,Albumin 4100ml,IGG Index 1.1mg,WBC 23/mm3,RBC 1/mm3, CSF IGG 3.6 mg/DL,Lymphocytoid 97%, protein, neutrophils, glucose, CSF albumin all norm. Any ideas?

CSF Results: If I am reading the results correctly, there appears to be a mononuclear pleocytosis with normal protein, glucose and essentially normal immune response. The fluid analysis cn be seen in many disorders including viral meningitis. Need additional information. ...Read more

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Normal C-RP, Sed Rate, CBC, CMP, Rheumatoid fac., C3/C4 Complement and Cyclic Citrul peptide. ANA was negative. Does this rule out any auto-immune?

Normal C-RP, Sed Rate, CBC, CMP, Rheumatoid fac., C3/C4 Complement and Cyclic Citrul peptide. ANA was negative. Does this rule out any auto-immune?

Not necessarily: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, Lab test do not equate to disease or the lack of it. It is good that all the test results are negative. It reduces your risk of an auto-immune disease to very very low, but does not exclude it 100%. ...Read more

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What is IgE serum?

What is IgE serum?

IgE: In serum measures the level of IgE circulating in the blood stream, it is the immunoglobulin that binds to the surface of certain cells, mast cells and basophills, and responsible for acute type I allergic reactions. IgE measures the amount of circulating IgE not the bound IgE, it is elevated in certain diseases ...Read more

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What does a high IgE level mean?

What does a high IgE level mean?

Allergy/asthma: Ige is an antibody that is commonly elevated in people with a tendency towards allergic disease. While there are other potential causes, the most common culprits are asthma, allergic rhinitis (hayfever), and eczema. ...Read more

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What could cause high IgE levels?

What could cause high IgE levels?

Genetics: The tendency to make more ige in response to foreign substances that enter the body (aka allergens) is inherited. Allergies and parastic infections are the common reasons why people develop high ige levels. There are some rare disorders associated with increased risk of infections associated with very high levels of ige. A board-certified allergist can help sort this out for you. ...Read more

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How accurate are IgG and IgE testing?

Very.: Generally pretty definitive. Testing for immunoglobulin is done by a highly sensitive and specific method. ...Read more

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If my IgE level is high what am I suffering?

If my IgE level is high what am I suffering?

Allergies: High ige levels are generally a marker for allergic potential. Therefore, the higher your ige, the more likely you are to have allergic diseases such as hayfever, asthma, or eczema. ...Read more

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Is IgE realted to PLC/PLEVA? And How to Cure it?

Is IgE realted to PLC/PLEVA? And How to Cure it?

Usually not: If you have very high igE it is possible that you have some underlying blood cell disease which should be identified and treated. Sometimes these cause skin changes masquerading as PLEVA. Otherwise there is no satisfactory treatment. Discuss with your DR. ...Read more

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Ige reference range and results, how to interpret?

Ige reference range and results, how to interpret?

See Below: Total IgE reference range varies with age and normals are established for individual reference labs as well. Typically in an adult a normal level is,less than 150, but it is not uncommon for patients with allergies to have levels in 500-600 range and patients with eczema can go to levels in the 1000-2000 range. Really high IgE, like 5000 and up can indicate immune system disease or parasite ...Read more

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IGE level is above 630 is this alarming situation?

No: People vary tremendously in IgE levels. There's still little knowing what it means. How does Junior feel? ...Read more

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Can you do anything to lower IgE levels? Is there any medication out there for this?

Yes but why?: Unless you have an illness which demands the treatment, there is no reason to lower the ige level since the options are not devoid of major side effects. ...Read more

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Are you saying an IgE of zero means imunodeficiency? Are there any additional testing recommendations.

Are you saying an IgE of zero means imunodeficiency?  Are there any additional testing recommendations.

No allergy: Ige is an antibody that fights parasitic infections and reacts to allergens, it does not provide immunity from bacteria or viruses. We call it an immunodeficiency only if iga, m or g are below certain standard values. ...Read more

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My 3yrs daughter coughs at night 1 month. Pneumoslide and total IGE negative. Feels well during day time. What can it be?

My 3yrs daughter coughs at night 1 month. Pneumoslide and total IGE negative. Feels well during day time. What can it be?

Cause of night cough: It could be due to wheezing- Give age & weight calculated amount of benadry or any other antihistamines & see if cough stops.
Did you talk to the pediatrician? ...Read more

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I was told I have a total IgE level of 1, 795. Is this significant? Is it higher than normal? What health risks are associated with it?

I was told I have a total IgE level of 1, 795. Is this significant? Is it higher than normal? What health risks are associated with it?

IgE: The ige level you mention is total allergic antibody level circulating in your body. It is quite high. Depending on normal values of each lab, a normal one is usually less than 200. High ige associate with several allergic conditions. The most common ones are allergic rhinoconjunctivitis or hay fever, asthma, eczema.... Certain infections can drive a high level of ige like that too. ...Read more

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Hi i have ige reading of 3,850 is it genetic?

Hi i have ige reading of 3,850 is it genetic?

Can Be...: Elevated total serum IgE is seen in mainly allergic diseases like allergic rhinitis and eczema. It is also seen in some primary immunodeficiencies, parasitic and viral infections, certain inflammatory diseases, and some malignancies. Atopic conditions like allergic rhinitis and eczema definitely have a genetic component to them. ...Read more

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Can I lower my ige?

Can I lower my ige?

Yes: Treatment of atopic disease, such as atopic dermatitis or asthma, can result in lowered IgE. The B-cells that make IgE depend on certain signals in the body to live and produce antibody. Time, changes in environmental/food/drug exposure, medicating specific diseases can all result in decreases in both total and specific IgE levels ...Read more

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Is 2.26 ige too high?

It is high: But why depends on your general health it depends on what your diagnosis is as to why it may be all elevated . You' need an. Evaluation possibly by an allergist ...Read more

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What does low IgE means ?

What does low IgE means ?

Reduced allergy: If the ige is low it makes an allergic diathesis less likely but not zero. Additionally, the ige level could be reduced by taking prednisone/cortisone. ...Read more

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