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Doctor insights on: Diffused Lymphoma Patients Symptoms Abnormalities

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Do diffused large b cell lymphoma patients show symptoms of mental abnormalities?

Do diffused large b cell lymphoma patients show symptoms of mental abnormalities?

Maybe: In general we don't think of diffuse large b cell lymphoma (dlbcl) effecting brain function. However, many patients tell us of symptoms of a "fog" like feeling either before treatment (disease-related?) or after ("chemobrain"). Reasons are likely multifactorial and can include stress, financial concerns, depression, and disease biology. This is being actively studied by a variety of groups. ...Read more

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Dr. Michael Thompson
1,755 doctors shared insights

Lymphoma (Definition)

A malignancy developing in the lymphocytes of lymph glands. They present as an enlarging node that continues to grow and then ...Read more


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Result of CT scan states " findings are mediastinal lymphadenopathy and soft tissue nodules both lungs in all segments(extensive metastatic disease) "?

Result of CT scan states " findings are mediastinal lymphadenopathy and soft tissue nodules both lungs in all segments(extensive metastatic disease) "?

Very concerning...: These findings are extremely concerning and you need to discuss this with your healthcare team. You will likely undergo more tests and referrals to specialists who will provide you more detailed answers than what I am able to do. Do not delay. ...Read more

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Are there cancers that could cause mild liver enlargement (16.7) without focal lesions? Also mild elevated ALT. Or would cancer always show focal?

Are there cancers that could cause mild liver enlargement (16.7) without focal lesions? Also mild elevated ALT. Or would cancer always show focal?

Hepatomegaly: Hepatomegaly, or enlarged liver, is not usually a sign of liver cancer. There are many other things that can cause a large liver and an increase in the ALT. It is important to find the reason for the symptoms, to treat it before it becomes worse. You should see a gastroenterologist if you have not already. Good luck. ...Read more

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Disseminated peritoneal disease with long segment bowel wall thickening, multiple hepatic and renal nodules - are in favour of neoplastic etiology?

Disseminated peritoneal disease with long segment bowel wall thickening, multiple hepatic and renal nodules - are in favour of neoplastic etiology?

7 YO? Can't post yet: Have to be 17 to post. Seven years old is too young to post, and requires speaking to your pediatrician about your questions until you're old enough to post. Thanks! ...Read more

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What specific blood/urinalysis levels are significant to kidney problems of diagnosis but untreated lupus patient. Symptoms? Failure or disease? Difference?

What specific blood/urinalysis levels are significant to kidney problems of diagnosis but untreated lupus patient. Symptoms?  Failure or disease? Difference?

See answer : Blood tests for bun, creatinine, and GFR are used to determine if you have chronic kidney disease (ckd) and what stage (1 thru 5) based on GFR result. Urinalysis helpful to detect microscopic blood and protein both of which are common with kidney disease with degree of each related to type and severity of kidney disease. If significant protein (>1+), then 24-hr urine collection done to quantitate. ...Read more

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Mri: sm. Amt of subcortical/periventricular signal. Meaning? Mild encephalomalacia. Meaning? history sle, ra, meningioma sx. Age 59. Mri due to dizzyness.

Mri: sm. Amt of subcortical/periventricular signal. Meaning?  Mild encephalomalacia. Meaning? history sle, ra, meningioma sx. Age 59. Mri due to dizzyness.

Non-specific changes: I do not see anything serious in this report. Slight changes of this or that are commonly reported by radiologists. But it is your treating doctors job to put these in proper perspective. All i can see it is that these changes do not point me in any direction except that it can serve as a base line for future comparisons to see if there is any progressive changes in future. ...Read more

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What does all this mean..Heterogeneous glandular tissue w mild increased vascularity suggestive of thyroiditis/no focal lesion identified?

What does all this mean..Heterogeneous glandular tissue w mild increased vascularity suggestive of thyroiditis/no focal lesion identified?

Goiter/FNA: If this is your fna/fine needle aspirate result, then your doc will likely recommend medication and monitoring for your thyroid disease. ...Read more

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What are the major presenting symptoms associated with chronic leukemia?

What are the major presenting symptoms associated with chronic leukemia?

Varies: Majority cases are asymptomatic and the evaluation is started due to abnormal blood work. When the leukemia is more advanced - patient can become symptomatic-and can be presented with-anemia, low platelet level- bleeding, increase white blood counts, recurrent infections, fatigue/decrease energy level, fever/chils/night sweats, increase abdominal girth etc. Read more : www.Cancer.Net / www.Lls.Org. ...Read more

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What symptoms are typically associated with lung cancer?

What symptoms are typically associated with lung cancer?

From nothing: To terminal. Early on, no symptoms. May be identified on x-ray or ct for something independent. Cough hemoptysis- coughing blood pain in apex or chest wall shortness of breath. Progress from tiny, to small stage 1, to local spread to lymph nodes, to spread with distant metastasis stage 4. ...Read more

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What causes nonischemic cardiomyopathy and extensive bilateral nodule infiltrates?

What causes nonischemic cardiomyopathy and extensive bilateral nodule infiltrates?

Consider sarcoidosis: Sacoidosis can cause diffuse micronodular changes in lung tissue and in the less common cases of cardiac infiltration a dilated nonischemic cardiomyopathy (may also cause a restrictive cm). Other possibilities include viral or other chronic inflammatory conditions which affect the lungs and heart simultaneously. ...Read more

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MRI scan shows two small focal flair hot spots in either frontal lobes subcortically. Mild peri ventricular gliosis. Age related mild diffuse atrophy.

MRI scan shows two small focal flair hot spots in either frontal lobes subcortically. Mild peri ventricular gliosis. Age related mild diffuse atrophy.

Probably not...: ...significant. A few small lesions can be seen in many patients without an underlying problem. If there is any concern, then a repeat MR in 4-6 months can be performed. Without any interval change, then you should not worry. However, atrophy at your age is more worrisome and not common, and your Doctor should examine you closely for any underlying cause. ...Read more

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MRI=enhancingT2hyperintense foci in both cerebellar regions may represent demyelinating disease. Other less likely metastasis or any infiltrative?

MRI=enhancingT2hyperintense foci in both cerebellar regions may represent demyelinating disease. Other less likely metastasis or any infiltrative?

Complex question.: We will need to discuss your symptoms to figure out the significance of any such "findings" on the MRI. This isn't the forum to discuss- use HealthTap Prime or talk to your doctor / neurologist. In the mean time, obtain the MRI pictures & upload the pictures + report onto your computer. A metastasis in BOTH cerebellums, symmetrically, is ridiculously improbable. Can't say much more here. Good luck ...Read more

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Does early stage small cell lung cancer cause muscle loss and malabsorption or are these later symptoms?

Does early stage small cell lung cancer cause muscle loss and malabsorption or are these later symptoms?

Lung cancer cachexia: Muscle wasting and weight loss ("cancer cachexia") are usually late stage occurrences; malabsorption is usually not the cause of these signs, but rather "hormones" released from the tumor cause a hyper metabolic state and also contribute to poor appetite. If you are already experiencing these problems, however, it is possible that the tumor - although localized (stage 1) is unusually active. ...Read more

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What symptoms are associated with pituitary tumors?

What symptoms are associated with pituitary tumors?

Visual & endocrine: Any tumor of the pituitary may affect the optic nerve and produces visual disturbances. The endocrine symptoms depend on the cell type involved and if it makes a hormone. If the tumor does not make hormones it causes deficiency of thyroid, adrenal and gonadal hormones. Excess production of hormone may cause hyperthyroidism and cushing syndrome etc. ...Read more

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Mri result very few scattered punctate foci of flair 2 signal abnormality seen in periventricular and subcortical white matter. history concussion, htn?

Mri result very few scattered punctate foci of flair 2 signal abnormality  seen in periventricular and subcortical white matter. history concussion, htn?

More likely HTN: Mri scans that demonstrate the scattered periventricular signal changes are likely showing changes from hypertension. This is a typical location for this. Severe concussions may show some signal abnormalities along the white matter tracks (diffuse axonal injury) rather than in the periventricular zones. ...Read more

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Do b symptoms eventually develop in lymphoma? Are there stage 4 patients with no b symptoms?

B Symptoms: B symptoms are any combination of persistent fevers, drenching night sweats/chills, or significant weight loss. Not all lymphoma patients get them. Not even all stage IV lymphoma patients get them. Patients without b symptoms and stage IV disease are staged as having stage iva disease. ...Read more

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3mm hypodense liver lesion in caudate lobe & two 3mm hypodense pancreatic head lesions on CT in setting of carcinoid workup. Can these be tumors?

3mm hypodense liver lesion in caudate lobe & two 3mm hypodense pancreatic head lesions on CT in setting of carcinoid workup. Can these be tumors?

May or may not be: It takes time and follow up CT scans to see if these tumors are growing in size. if they are not tumors(cancer) it will remain unchanged in size over a period of 3-6 months. A biopsy may be required to confirm it in case these lesions are increasing in size(growing bigger). They are too small to do a biopsy now, need to be at least 1Cm or bigger. ...Read more

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Do diffused large b cell lymphoma patients show symptoms of mental abnormalities?

Maybe: In general we don't think of diffuse large b cell lymphoma (dlbcl) effecting brain function. However, many patients tell us of symptoms of a "fog" like feeling either before treatment (disease-related?) or after ("chemobrain"). Reasons are likely multifactorial and can include stress, financial concerns, depression, and disease biology. This is being actively studied by a variety of groups. ...Read more

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Do b symptoms eventually develop in lymphoma? Are there stage 4 patients with no b symptoms?

B Symptoms: B symptoms are any combination of persistent fevers, drenching night sweats/chills, or significant weight loss. Not all lymphoma patients get them. Not even all stage IV lymphoma patients get them. Patients without b symptoms and stage IV disease are staged as having stage iva disease. ...Read more

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What is the best way to recover from low WBC after chemotherapy (r-cvp for stage 2 diffuse large b-cell lymphoma) for a very elderly (85y) patient?

What is the best way to recover from low WBC after chemotherapy (r-cvp for stage 2 diffuse large b-cell lymphoma) for a very elderly (85y) patient?

It depends.: R-cvp is a relatively milder regimen and therefore it does not usually result in very low wbcs. In general, modest decrease in WBC is expected and is not associated with higher risk for infections unless WBC become very low with neutrophil count below 500. If this is the case, you doctor may decide to use a growth factor given after chemotherapy to stimulate your bone marrow to produced wbcs. ...Read more

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Is beta-2-micro globulin typically elevated in lymphoma patients?

A prognositic factor: levels are incorporated into staging system for multiple myeloma. Higher levels in 75% cases can correlated with higher tumor burden. ...Read more

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If a patient is in critical condition with lymphoma, can it be treated?

If a patient is in critical condition with lymphoma, can it be treated?

Lymphoma treatment: I am assuming by treatment you are referring to chemotherapy. Usually we would like one to be relatively healthy other than the tumor itself, before administering chemotherapy . Therefore in answer to your question, probably not a good idea. ...Read more

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How long can t cell lymphoma patients live?

Many types : There are many types of t cell lymphoma. Some types are very slow growing, treatable but not curable..Patients can live for decades. Other types are much more aggressive. Some are highly treatable and even can be cured while others are quite difficult to get into remission. ...Read more

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Average life span for patients with mantle cell lymphoma?

Average life span for patients with mantle cell lymphoma?

Stage ?: Depends on stage. There are two subsets of mantle cell nhl. One is an indolent subset in which 5 yr survival approaches 70-80%. The othe more aggressive subset has a prognosis of only 50/50 at three years. But stage also matters. ...Read more

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Is ldh always high with lymphoma patients? Any other tests (blood tests)

Is ldh always high with lymphoma patients?  Any other tests (blood tests)

No: Ldh may be high in lymphoma, but may not be. There are many laboratory and other tests used in the initial staging and prognostic testing for lymphoma. Also some tests are used before initial treatment because of concern of viral reactivation -- eg hiv, hepatitis studies. ...Read more

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Lymphoma starts in the immune system. Does that make a patient more prone to everyday illnesses? (colds, flu, etc?)

Probably: Lymphoma, as any other cancer, may be related to decreased immunity from the beginning (decreased immunity is one of the factors favoring the appearance of cancer) or may result in decreasing immunity due to progression of disease. Also, chemotherapy for lymphoma may cause decreased immunity. So yes, these patients are more prone to various infections. ...Read more

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How safe is Rituxan (rituximab) for lymphoma? How about in patients with Cardiac disease?

How safe is Rituxan (rituximab) for lymphoma? How about in patients with Cardiac disease?

Safe: Rituxin is one of the few mAbs that can destroy a tumor by inducing antibody dependent cell cytoxicity (ADCC) by targeting CD20 on the lymphocyte. This surface antigen is present in all lymphocytes including lymphoma. But the lymphocyte population is reestablished every 24hr causing no major side effects. It improved CHOPP survival from 50% to better than 80% without cardiac toxicity. ...Read more

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Review of tonsillar lymphoma in pediatric patients from the pediatric oncology group: what can be learned about some indications for microscopic examination?

Review of tonsillar lymphoma in pediatric patients from the pediatric oncology group: what can be learned about some indications for microscopic examination?

Data says don't: There have been a number of studies (2005 pog study and more recently in 2011 and 2012) to suggest that always doing microscopic examination on routine tonsillectomies is not cost effective. If someone has a index of suspicion (clinical or asymmetric enlargement), then it is warranted. It has been estimated that not doing this automatically could save ~$35 million per year. ...Read more

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Could hydroxyurea therapy cause leukemia and/or lymphoma among patients?

Could hydroxyurea therapy cause leukemia and/or lymphoma among patients?

Possibly: The agent is considered mutagenic and although the risk is low, it is a real one. ...Read more

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How long does a patient have with stage IV non hodgkin lymphoma onchemotherapy ?

Very hopeful: This cancer ios often curable, so we must be very hopeful and do the treatment well so the results will be good. ...Read more

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What is the life expectancy for a CHF patient with hodgkin lymphoma if they are not treated?

What is the life expectancy for a CHF patient with hodgkin lymphoma if they are not treated?

Depends: Hodgkin lymphoma is a highly curable cancer. Severe CHF might limit some of the chemotherapy options, but even in the unusual circumstance that no chemotherapy could be given, cures can still be achieved with radiotherapy alone. Life expectancy for untreated disease depends on a number of factors but is likely to be only about 12 months on average with some doing better and some worse. ...Read more

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Can a patient with lymphoma recover by having a bone marrow transplant?

Can a patient with lymphoma recover by having a bone marrow transplant?

Recover?: What do you mean by recover? A bone marrow or stem cell transplant can be part of the therapy for lymphomas. For some types of lymphoma it can help improve the chances of curing the cancer. It's role is depedent on many factors that would need to be discussed with an oncologist. ...Read more

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