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Doctor insights on: Diffuse Cutaneous Mastocytosis

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What is cutaneous mastocytosis?

What is cutaneous mastocytosis?

Mastocytosis: Mastocytosis is as skin disease where mast cells (a type of white blood cell containing histamine) accumulate in the skin--can be isolated or solitary or can be diffuse with multiple lesions. Needs to be seen by dermatologist. ...Read more

Dr. Brant Ward
47 doctors shared insights

Mastocytosis (Definition)

Mastocytosis is a condition in which the body produces too many mast cells. These overgrown mast cells can be confined to the skin (cutaneous mastocytosis), or can be located in the bone marrow and throughout the body (systemic mastocytosis). Symptoms of these disorders vary by location and type, but are thought to be caused by the release of chemical mediators like histamine ...Read more


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Cutaneous leishmaniasis symptoms?

Cutaneous leishmaniasis symptoms?

Sores : Typically single (or occasionally multiple) non-tender sores or ulcers. ...Read more

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Skin biopsy result: superficial to mid dermal perivascular lymphocytic infilitrate with focal basal vacuolar changes.does thismean allergic vasculitis?

Skin biopsy result: superficial to mid dermal perivascular lymphocytic infilitrate with focal basal vacuolar changes.does thismean allergic vasculitis?

No: There is no involvement of the blood vessels themselves- thus not vasculitis by definition. This is a very common skin biopsy finding which has no diagnostic meaning other than ruling out a more serious condition. ...Read more

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What is chronic cutaneous lupus erthremyphosis

What is chronic cutaneous lupus erthremyphosis

See: Subacute cutaneous lupus is a subtype of lupus that can have a lupus and be associated with positive antibodies for sjogren's as well as thyroid disease. Rarely, does it ever transition to systemic lupus. Hope that helps. ...Read more

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Vacuolar interface dermatitis, tight superficl perivascular & periadnexial lymphocytic infiltrate, mild incr. In dermal mucin. No fungus.-rash biopsy.?

Vacuolar interface dermatitis, tight superficl perivascular & periadnexial lymphocytic infiltrate, mild incr. In dermal mucin. No fungus.-rash biopsy.?

Varied possibilities: These findings suggest several possible entities.Based on this description of biopsy findings diagnoses including connective tissue disease such as lupus erythematosus may be considered, as well as a drug reaction. However, the only way to accurately make a diagnosis is to correlate the biopsy findings with the clinical presentation and other symptoms a patient may be having. ...Read more

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Is systemic mastocytosis life-threatening?

Is systemic mastocytosis life-threatening?

Usually not: Most people with systemic mastocytosis (sm) have a normal lifespan. Episodes of anaphylaxis with sm can be dangerous if not treated properly, so it's important to use Epipen (epinephrine) and lay flat with the feet elevated slightly. Rarely, sm can be aggressive or associated with a leukemia. In these cases, lifespan may be shortened, but the sm may respond to chemo. See a specialist in masto for more info. ...Read more

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What causes cutaneous hyperesthesia?

What causes cutaneous hyperesthesia?

Allodynia newer name: Cutaneous hyperesthesia is a bit dated. Several things such as migraines, acute appendicitis, radiculopathies of the cervical and lumbar spines, Shingles or a herpetic skin infection can cause this heightened sensation of the skin which can also be seen in a condition know as Complex Regional Pain Syndrome or (CRPS) which can occur after a major injury, surgery/operation, or long bone fracture. ...Read more

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Myxofibrosarcoma presenting in the skin: clinicopathological features and differential diagnosis with cutaneous myxoid neoplasms.?

Myxofibrosarcoma presenting in the skin: clinicopathological features and differential diagnosis with cutaneous myxoid neoplasms.?

Fairly common: The differential diagnosis will be made by the pathology team. My teacher hector battifora was among the world's most distinguished sarcoma pathologists but said he would never sign one out without another pathologist. The low nuclear grade ones rarely metastasize / kill, but all are prone to annoying local recurrences. Good luck, glad it's this relatively tame (still dangerous) cancer. ...Read more

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What is cutaneous amyloidosis macular?

What is cutaneous amyloidosis macular?

A skin condition: Macular describes the localized rash (spots) that occur with amyloid. As it is a deposition disease, they are actually amyloid deposits. ...Read more

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Help understand skin biopsy result: "There is a sparse perivascular lymphohistiocytic inflammatory infiltrate. CD117 highlights only a few scattered mast cells. Diagnosis: Mild superficial perivascular infiltrate." Anything of concern here?

Help understand skin biopsy result: "There is a sparse perivascular lymphohistiocytic inflammatory infiltrate. CD117 highlights only a few scattered mast cells. Diagnosis: Mild superficial perivascular infiltrate."  Anything of concern here?

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the findings listed in the report are non-specific and non-diagnostic. Do you have any symptoms? Why was the biopsy done? ...Read more

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Which percentage of diagnosed lupus cases are sle, systemic lupus erythmatosus?

Lupus: Lupus comes in 4 major types: systemic, discoid (skin only), neonatal, and drug-induced. Some people who have an abnormality in their immune system and fail to make a body defense protein called complement are also at risk for developing lupus. It has been estimated that 1.5 million people in the US have one of these lupus forms. Women are 2-3 times more likely to develop this disease than men. ...Read more

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Derm biopsy report: mild vacuolar dermatitis with scattered papillary dermal interstitial eosinophils and perivascular lymphocytes. What does it mean?

Derm biopsy report: mild vacuolar dermatitis with scattered papillary dermal
interstitial eosinophils and perivascular lymphocytes. What does it mean?

Biopsy report: You need to discuss this with the person who did the biopsy and ordered the report. They are in the best position to interpret it. We don't even know where the biopsy was from. ...Read more

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What is mild superficial perivascular lymphocytic inflammation?

What u r describing: Sounds like a lymphocytic dermatitis; these rashes can be caused by reactions to medications or alternatively other allergic reactions. Speak with your physician for further insight. ...Read more

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What causes cutaneous nerve hypersenitivity?

What causes cutaneous nerve hypersenitivity?

Pressure partial : Pressure, partial injury crus complete injuries are numb partial can have dysethesia. ...Read more

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What is lichenoid muscositis with perivasculitis, ulcerated?

What is lichenoid muscositis with perivasculitis, ulcerated?

Mucosal rash: This is inflammation of the mucous membranes that hugs underside of epidermis=lichenoid. Perivasculitis=inflammation around blood vessels. In mouth, can be lichen planus, lichenoid drug or allergic contact reaction, autoimmune diseases & others. Even canker sores. Direct immunofluorescence biopsy to tell which. In vulva, can also be lichen sclerosus. Some have risk of mouth cancer. Get diagnosis. ...Read more

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Cutaneous (Definition)

Skin is the largest and one of most complex organs of body. 3 layers: epidermis (outer), dermis (main part) and subcutaneous layers covers entire body, contains many specialized cells, maintains body temp, gathers sensory info from the outer world, has extremely important immune functions. It can give crucial clues as to what is internal. Dermatology and plastic surgery are ...Read more