Doctor insights on:
Diffuse Cutaneous Mastocytosis
Mastocytosis is a condition in which the body produces too many mast cells. These overgrown mast cells can be confined to the skin (cutaneous mastocytosis), or can be located in the bone marrow and throughout the body (systemic mastocytosis). Symptoms of these disorders vary by location and type, but are thought to be caused by the release of chemical mediators like histamine ...Read more
Skin biopsy result: superficial to mid dermal perivascular lymphocytic infilitrate with focal basal vacuolar changes.does thismean allergic vasculitis?
Vacuolar interface dermatitis, tight superficl perivascular & periadnexial lymphocytic infiltrate, mild incr. In dermal mucin. No fungus.-rash biopsy.?
Varied possibilities: These findings suggest several possible entities.Based on this description of biopsy findings diagnoses including connective tissue disease such as lupus erythematosus may be considered, as well as a drug reaction. However, the only way to accurately make a diagnosis is to correlate the biopsy findings with the clinical presentation and other symptoms a patient may be having. ...Read moreSee 3 more doctor answers
Usually not: Most people with systemic mastocytosis (sm) have a normal lifespan. Episodes of anaphylaxis with sm can be dangerous if not treated properly, so it's important to use Epipen (epinephrine) and lay flat with the feet elevated slightly. Rarely, sm can be aggressive or associated with a leukemia. In these cases, lifespan may be shortened, but the sm may respond to chemo. See a specialist in masto for more info. ...Read more
Allodynia newer name: Cutaneous hyperesthesia is a bit dated. Several things such as migraines, acute appendicitis, radiculopathies of the cervical and lumbar spines, Shingles or a herpetic skin infection can cause this heightened sensation of the skin which can also be seen in a condition know as Complex Regional Pain Syndrome or (CRPS) which can occur after a major injury, surgery/operation, or long bone fracture. ...Read more
Myxofibrosarcoma presenting in the skin: clinicopathological features and differential diagnosis with cutaneous myxoid neoplasms.?
Fairly common: The differential diagnosis will be made by the pathology team. My teacher hector battifora was among the world's most distinguished sarcoma pathologists but said he would never sign one out without another pathologist. The low nuclear grade ones rarely metastasize / kill, but all are prone to annoying local recurrences. Good luck, glad it's this relatively tame (still dangerous) cancer. ...Read more
Help understand skin biopsy result: "There is a sparse perivascular lymphohistiocytic inflammatory infiltrate. CD117 highlights only a few scattered mast cells. Diagnosis: Mild superficial perivascular infiltrate." Anything of concern here?
See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the findings listed in the report are non-specific and non-diagnostic. Do you have any symptoms? Why was the biopsy done? ...Read more
Lupus: Lupus comes in 4 major types: systemic, discoid (skin only), neonatal, and drug-induced. Some people who have an abnormality in their immune system and fail to make a body defense protein called complement are also at risk for developing lupus. It has been estimated that 1.5 million people in the US have one of these lupus forms. Women are 2-3 times more likely to develop this disease than men. ...Read moreSee 1 more doctor answer
Derm biopsy report: mild vacuolar dermatitis with scattered papillary dermal
interstitial eosinophils and perivascular lymphocytes. What does it mean?
Mucosal rash: This is inflammation of the mucous membranes that hugs underside of epidermis=lichenoid. Perivasculitis=inflammation around blood vessels. In mouth, can be lichen planus, lichenoid drug or allergic contact reaction, autoimmune diseases & others. Even canker sores. Direct immunofluorescence biopsy to tell which. In vulva, can also be lichen sclerosus. Some have risk of mouth cancer. Get diagnosis. ...Read moreSee 2 more doctor answers
How do the rashes associated with annular lichen planus and subacute cutaneous lupus differ in appearance?
No: They are distinctly separate disorders.Get a more detailed answer ›
Does infectious disease specialist treat or study systemic scleroderma. Undifferentied diffuse connective tissue disease,raynauds?
No: these are generally dealt with by rheumatologists. Good luck. ...Read more
Skin is the largest and one of most complex organs of body. 3 layers: epidermis (outer), dermis (main part) and subcutaneous layers covers entire body, contains many specialized cells, maintains body temp, gathers sensory info from the outer world, has extremely important immune functions. It can give crucial clues as to what is internal. Dermatology and plastic surgery are ...Read more