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Doctor insights on: Differences Between Oxycodone And Hydrocodone

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What's the difference between oxycodone and hydrocodone?

What's the difference between oxycodone and hydrocodone?

Oxy vs hydro: They are both opioid analgesics. They are used for pain management, and both have potential for abuse and dependency. Oxycodone is more potent. Hydrocodone; vicodin, lortab contains 500 of Acetaminophen with it. Oxycodone; Percocet 10/325, and 5/325, Percocet 10/650, also has Acetaminophen in it in various dosages. Abuse of these drugs may cause severe liver damage due to the Acetaminophen content. ...Read more

Hydrocodone (Definition)

Hydrocodone or dihydrocodeinone is a semi-synthetic opioid derived from two naturally occurring opiates: Codeine or thebaine. It is an orally active narcotic analgesic and antitussive. It is available in tablet, capsule, and syrup form. It is used to treat moderate to severe pain or as an antitussive to treat cough. Hydrocodone affects pain by ...Read more


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What’s the difference between oxycodone and hydrocodone? Why would my doctor sometimes prescribe one and sometimes the other (for different problems)?

What’s the difference between oxycodone and hydrocodone? Why would my doctor sometimes prescribe one and sometimes the other (for different problems)?

Oxy is stronger : Oxycodone is about 1.5 times stronger than hydrocodone. Usually hydrocodone is prescribed first. If pain is not controlled, then physicians may move to oxycodone. That being said, sometimes it's just physician preference based on his or her patient population. ...Read more

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How much difference is there between oxycodone and hydrocodone?

How much difference is there  between oxycodone and hydrocodone?

Same: Oxy and hydro are equivalent when taken by mouth on a milligram for milligram basis mouth. There may be individual variation in response. ...Read more

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What's the difference between hydrocodone and oxycodone?

Very similar: Both are narcotic analgesics, with similar effects and side-effects. Each person reacts differently to medications, so one might work better for you than another. There are no distinct advantages of one over the other. ...Read more

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Whats are differences between hydrocodone and oxycodone?

Similar opiates: Hydrocodone is a semi-synthetic opiod derived from two of the naturally occuring opiates, Codeine and thebaine. Oxycodone is an opioid medication synthesized from thebaine. It does not contain codeine. ...Read more

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Please advise what is the difference between hydrocodone and oxycodone?

Pain killers: Different chemical structure, different strength , but you should ask this question to the specialist, unless you have something else in mind, that could cause you a trouble. ...Read more

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I've been prescribed 15mg oxycodone to replace the 10mg hydrocodone i was taking. How big of a difference is this?

Almost twice: The dose. I would be cautious making this large of a jump in pain medications. I would carefully discuss this with your prescriber. Be aware of increased side effects including sedation, breathing issues and constipation. ...Read more

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Please help! what is the difference between hydrocodone and oxycotin/oxycodone other than being more powerful?

Please help! what is the difference between hydrocodone and oxycotin/oxycodone other than being more powerful?

Not much: Hydrocodone and oxycodone are very similar, which hydrocodone being 25-33% less potent (so oxycodone 5 mg is equivalent to about 7.5 mg of hydrocodone). Both have the same pharmacological reaction, both can cause the same problems and dependency, but hydrocodone tends to have more side effects from histamine release- itching, flushing, nausea, diarrhea- than oxycodone. ...Read more

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Do blood test show drug use? More specific can a blood test determine the difference between hydrocodone and oxycodone?

Yes: If a blood test specifically for drugs is obtained, then it is likely that it will determine the presence of both hydrocodone and oxycodone. Urine drug tests can detect the difference and are usually done instead of blood tests since drug levels are detectable in the blood for a much shorter period of time than in the urine. ...Read more

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Dr. Clifford Gevirtz
688 doctors shared insights

Oxycodone (Definition)

Schedule ii controlled medication. Opioid (semi-synthetic) used ...Read more


Dr. Clifford Gevirtz
491 doctors shared insights

Roxicodone (Definition)

Roxicodone is a drug that increases narcotic effects which is a ...Read more