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Doctor insights on: Difference Between Sudafed And Benadryl

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What's the difference between Benadryl (diphenhydramine) and sudafed?

What's the difference between Benadryl (diphenhydramine) and sudafed?

Medical questions: Benadryl (diphenhydramine) is an antihistamine, good for allergies and to lessen the drainage during an upper respiratory infection. Sudafed is a decongestant, good for helping you breath through a stuffy nose from a cold, bad allergies or sinus problems. Sudafed can also raise blood pressure, and shouldn't be taken on a regular basis. ...Read more

Dr. John Chiu
1,049 Doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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Can you give a child Benadryl (diphenhydramine) and sudafed at the same time?

Can you give a child Benadryl (diphenhydramine) and sudafed at the same time?

Avoid decongestants: Pseudoephedrine (sudafed) can cause irritability and high blood pressure in children but doesn't seem to actually help with congestion until puberty. Sudafed-pe (phenylephrine) has the same issues but typically is very poorly absorbed into the body. These drugs should never be given to children given the potential harm and lack of benefit.
Benadryl should be limited to once a day during a cold. ...Read more

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What is the recommended doseage schedule when taking both Sudafed with Benadryl (diphenhydramine) together?

What is the recommended doseage schedule when taking both Sudafed with Benadryl (diphenhydramine) together?

Every 6 hours: It is OK to use both together. Do not use either one more than 4 times in a 24 hour period (every 6 hours). Of course, follow the directions on the box that indicates the number of pills (dosage) to take at one time. Sudafed is a decongestant and benadryl (diphenhydramine) is an antihistamine so they have two different effects. ...Read more

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I took regular sudafed a few hours ago. Can I take a Benadryl (diphenhydramine) before I go to bed?

Yes: Yes. Benadryl (diphenhydramine) ins an antihistamine, and sudafed is a decongestant. There is no problem taking them together at their recommended dosages, as long as you don't have any medical conditions in which these medications are not recommended (check with your doctor if you are unsure). ...Read more

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Can I take Benadryl (diphenhydramine) and sudafed while taking Wellbutrin?

Can I take Benadryl (diphenhydramine) and sudafed while taking Wellbutrin?

Not sudafed: It is okay to take benadryl (diphenhydramine) while taking Wellbutrin, although a less sedating anti-histamine such as Claritin or Zyrtec might be a better choice. Sudafed can result in increased heart rate and/or blood pressure, and these effects may be worsened while taking Wellbutrin. Try taking guafenesin in the form of Robitussin or Mucinex, it is very safe and may be very helpful for your congestion. ...Read more

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I currently take flonase, benadryl, sudafed PE, &zyrtec, yet my allergies are not controlled. Avoid food sensitivities/worse after URI. Y nt controlled?

I currently take flonase, benadryl, sudafed PE, &zyrtec, yet my allergies are not controlled. Avoid food sensitivities/worse after URI. Y nt controlled?

Allergy triggers: You might be a candidate for allergy desensitization shots. Are you able to avoid allergens? Make your bedroom as allergen free as possible. Here is an article from the American College of Allergy Asthma and Immunology:
http://acaai. Org/allergies/allergy-treatment/environmental-trigger-avoidance ...Read more

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I had runny nose/congestion for 4 days, took Benadryl + Sudafed, runny nose gone now, but still need Sudafed at night to breathe. Should I be worried?

I had runny nose/congestion for 4 days, took Benadryl + Sudafed, runny nose gone now, but still need Sudafed at night to breathe. Should I be worried?

No: No, probably just a common cold, sometimes symptoms can last 10-14 days. Try not to use sudafed every night though. It is a decongestant and will work quickly to help you breathe, but can also cause side effects. Natural remedies like using a humidifier, nasal saline rinses, and drinking tea with honey before bed can help. ...Read more

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I have a horrible headache from sinus pressure I tried afrin nose spray and Benadryl (diphenhydramine) at night. I feel terrible? Would I benefit more from sudafed?

I have a horrible headache from sinus pressure I tried afrin nose spray and Benadryl (diphenhydramine) at night. I feel terrible? Would I benefit more from sudafed?

Maybe: It would be better to see some one for your problem. Afrin spray and benadryl (diphenhydramine) or not the best remedies for sinus complaints. Sudafed may help better, but you should see your physician to make sure that you are treating the right problem. ...Read more

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Is there a difference between Benadryl (diphenhydramine) and pseudoephedrine?

Is there a difference between Benadryl (diphenhydramine) and pseudoephedrine?

Benadryl (diphenhydramine) and Sudafed: Benadryl (diphenhydramine) is an antihistamine (blocks the histamine receptor) and sudafed is a decongestant. Basically sudafed grabs a hold of the blood vessels and squeezes them down for a period of time. Hence the reason that rebound congestion and high blood pressure are attributed to this medicine. ...Read more

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Taking 120 mg pseudoephedrine every 12 hours, 10 mg loratadine in morning, and one Benadryl (diphenhydramine) at bedtime, is this ok?

Taking 120 mg pseudoephedrine every 12 hours, 10 mg loratadine in morning, and one Benadryl (diphenhydramine) at bedtime, is this ok?

Medication question: It is okay to take the pseudoephedrine with the loratadine. However, the nighttime Benadryl (diphenhydramine) would be considered a duplication of the loratadine which is a 24 hour medication. Without knowing more about your medical history, I would not suggest that you do that. Instead, I would suggest discussing the optimum management of your medications with your doctor. ...Read more

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Is it possible for me to take sudafed, benedryl and ibuprofen together?

Is it possible for me to take sudafed, benedryl and ibuprofen together?

Possible with cautio: Sudafed (pseudoephedrine), Benadryl (diphenhydramine) and Ibuprofen are all otc, labels should be read carefully and care not to exceed recommended doses, they don't interact but use caution with multiple drugs. ...Read more

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Is pseudoephedrine safe for asthma as well as loratadine both in Claritin D because I know Benadryl (diphenhydramine) as an antihistamine is contraindicated?

Is pseudoephedrine safe for asthma as well as loratadine both in Claritin D because I know Benadryl (diphenhydramine) as an antihistamine is contraindicated?

Both of those: Medications are not contraindicated in asthma. Benadryl (diphenhydramine) is not contraindicated in asthma. Many asthmatics have allergies which are treated with antihistamines of which benadryl (diphenhydramine) is the gold standard. ...Read more

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Side effects of bendryl &sudafed? My heart was pounding, but I felt extreme drowsyness...i couldn't stop moving and part of my body, my skin was getting purple /red marks? But they go away. ..?

Yes: Yes sudafed can cause palpitation, increased in heart rate, and blood pressure, and anxiousness. That is the normal reaction to the drug. Benadryl (diphenhydramine) will cause drowsiness ant lethargic and slight confusion. The combination will do exactly what you did experience. All of these will exaggerated if you are dehydrated. That why number one rule in treating cola, sinuses, viral illnesses. Is hydration and hydration ...Read more

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Can you take pseudoephedrine with diphenhydramine?

Yes.: Psuedoephedrine is a sympathomimetic which may rev you up a bit. Diphenhydramine is an antihistamine (antiallergy) medication with some sedating properties as well. ...Read more

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Difference between loratadine and benadryl (diphenhydramine)?

Difference between loratadine and benadryl (diphenhydramine)?

Different drug class: Although both are antihistamines, they are different chemicals. Benadryl (diphenhydramine) is sedating. Loratadine is not. ...Read more

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What is the difference between loratadine and benadryl (diphenhydramine)?

Different antihistam: Both are antihistamines. Benadryl (diphenhydramine) is a sedating shorter acting antihistamine and Loratadine is a longer acting non sedating antihistamine. ...Read more

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What is the difference between the effects of pcp and Benadryl (diphenhydramine) overdoses?

PCP: Big difference. Too much Benadryl (diphenhydramine) can make you tired and sleepy and even a lettle confused but angel dust is a lot worse. To see effects go to http://www. Cmcsb. Com/pcpangel. Htm. ...Read more

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Is there a difference between taking Benadryl vs reactine? I had an anaphylactic allergic reaction a few weeks ago and was recommended to take 25-50 m

Is there a difference between taking Benadryl vs reactine? I had an anaphylactic allergic reaction a few weeks ago and was recommended to take 25-50 m

Both: Are anti-histamines. Benadryl however produced drowsiness whereas the newer anti-histamines (eg "Reactine") are less likely to do that! For anaphylaxis I would stick to BENADRYL. (Plus an EP-PEN!!!!!)
It has a long history of safety/effectiveness
Hope this helps
Dr Z ...Read more

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My throat is hurting, how can I tell the difference between an infection and allergies? I take Benadryl (diphenhydramine) and claritin, anything I can take to help me out

My throat is hurting, how can I tell the difference between an infection and allergies? I take Benadryl (diphenhydramine) and claritin, anything I can take to help me out

Infx vs allergy: Symptoms of allergy vs. Infection can overlap and distinction can be difficult. Allergy symptoms will usually readily improve with Benedryl, Zyrtec, Claritin or nasal sprays, but will often relapse when the medication has worn off. Infections are generally associated with more fatigue, achiness, fever and colored nasal discharge of sputum from cough. ...Read more

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What is the difference between hydroxyzine and diphenhydramine?

What is the difference between hydroxyzine and diphenhydramine?

Older antihstamines: Both medications are sedating antihistamines. Diphenhydramine is available over the counter in many forms; the best known brand name is benadryl (diphenhydramine). Prescription strength is 50mg. Atarax is available only by prescription, generic name is Hydroxyzine chloride (there is also Hydroxyzine pamoate, vistaril). If one takes either medication, that person should not drive. ...Read more

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Is there a difference between Dimenhydrinate and Diphenhydramine? Which one would be better to take occasionally for insomnia?

Both antihistamines: Both of these medications have drowsiness as a side effect. Dimenhydrinate also known as Dramamine works better for dizziness, nausea, motion sickness, or vertigo. Once in the body it GIFs converted to diphenhydramine so the effects may be similar except that The half-life of diphenhydramine (Benadryl) is shorter than the Dimenhydrinate. ...Read more

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What is the difference between diphenhydramine and fexomenadine.?

Antihistamines: They are both antihistamine, but different classes. Diphenhydramine is a1st generation antihistamine and fexomenadine is a second generation antihistamine. The second generation is generally less sedatingthan the first generation. ...Read more

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What is the difference between diphenhydramine and diphenhydramine hci?

The same: Brand name, Benadryl (diphenhydramine) is diphenylhidramine hcl salt, and they are the same. Other products may be a different salts such as diphenylhydramine citrate. ...Read more

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What is difference between diphenhydramine hydrochloride and doxylamine?

Very similar: Both have anti-allergy property and sedative property. Doxylamine seems to be marketed more for its sedative, or sleep medicine effects, while diphenylhydramine seems to be marketed for more anti-histamin effect. ...Read more

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Is there a difference between diphenhydramine and hydroxyzine for anxiety?

Is there a difference between diphenhydramine and hydroxyzine for anxiety?

Diphenhydramine?: People have a tendency to take benadryl- diphenhydramine for sleeplessness. Ideally is not the good medicine for anxiety. Side effects are more. Has some effects on the central nervous system, can cause confusion -especially in elderly people, mouth dryness, fast heart rate, urinary retention -more evident in elderly men with big prostate glands. We call this as anticholinergic effect. Hydroxine-ok ...Read more

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What's the difference between diphenhydramine and dimenhydrinate? I know they are similar.

Diphenhydramine: Diphenhydramine is an antiallergy drug best known as benadryl (diphenhydramine). Dimenhydrinate is an over-the-counter drug used to prevent nausea and motion sickness. Dimenhydrinate is a combination of two drugs: Diphenhydramine and 8-chlorotheophylline, a chlorinated derivative of theophylline. ...Read more

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Can you tell me if there is a difference between diphenhydramine hydrochloride and diphenhydramine HCI?

Can you tell me if there is a difference between diphenhydramine hydrochloride and diphenhydramine HCI?

No difference: You're rather precocious if you're really 9yo! Anyway, HCl is shorthand/abbreviation for hydrogen chloride (hydrochloride) so diphenhydramine is diphenhydramine, a 1st generation antihistamine used to deal w/allergy symptoms, but also known to be sedating, so it's often added to other medications intended for sleep, eg Tylenol (acetaminophen) + diphenhydramine = Tylenol (acetaminophen) PM; Excedrin + diphenhydramine = ExcedrinPM ...Read more

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Which is better to add with sudefed for uri? Benydryl or claritan?

Which is better to add with sudefed for uri? Benydryl or claritan?

Neither: Benadryl (diphenhydramine) and claratin are antihistamines, more useful for treating allergies than a uri. Benadryl (diphenhydramine) is sometimes added to combination cold medicines, mainly to help you sleep, . ...Read more

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Severe allergies. OTC don't work anymore except pseudoephedrine and benedryl (side effects). Recommend OTC. DO NOT SAY SEE A DOCTOR - can't afford?

Severe allergies. OTC don't work anymore except pseudoephedrine and benedryl (side effects). Recommend OTC. DO NOT SAY SEE A DOCTOR - can't afford?

Nasal sprays: You could try nasal sprays - Nasacort Allergy 24HR or NasalCrom, but these may take some time to work. Some patients do well with Saline nasal washes or Neti Pots. Also try using Zyrtec or Claritin instead of Benadryl, (diphenhydramine) to reduce side effects. ...Read more

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What are some differences between Benadryl (diphenhydramine) and claritin?

What are some differences between Benadryl (diphenhydramine) and claritin?

Side-effect profile: Benadryl (diphenhydramine) is one of the first generation anti-histamines which cross the blood-brain barrier and therefore causes sedation. It also has a significant drying effect in many patients. Claritin (loratadine) is a second generation and does not cross into the brain and therefore is considered non-sedating. It is usually less drying as well. ...Read more

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


Dr. Louis Vernacchio
405 Doctors shared insights

Pseudoephedrine (Definition)

Pseudoephedrine is a decongestant which is a kind of antihistamine type drug (common ...Read more