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Doctor insights on: Difference Between Lupus And Scleroderma

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Can you get scleroderma and lupus?

Can you get scleroderma and lupus?

Mixed Picture: It would be very rare (but not impossible) to truly have both diseases together. It would be more likely to develop a so-called "overlap syndrome" in which you have a single autoimmune disorder that seems to borrow some features from each of these classic diseases without truly being purely one or purely the other. ...Read more

Dr. Michael Kleerekoper
136 doctors shared insights

Dermatosclerosis (Definition)

Dermatosclerosis (also known as scleroderma), is a disease of the connective tissue, causing tightening and ...Read more


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Does low c3c and 4 go with lupus rather than scleroderma?

Yes: Serum complements are normal in scleroderma but may be depressed in lupus. However, i would caution against putting too much importance on c3 and c4 levels as a diagnostic tool. They alone do not determine which disease is present. ...Read more

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Which symptoms 1st appear in someone with lupus or scleroderma?

Which symptoms 1st appear in someone with lupus or scleroderma?

It depends: There are several different symptoms that can appear, but it all depends on the patient. ...Read more

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Is low c3c and low c4c more indicative of lupus than scleroderma?

Is low c3c and low c4c more indicative of lupus than scleroderma?

Yes: Complement C3 and C4 are not indicators of scleroderma. Markers such as the centromere and the Scl-70 antibodies can be helpful in diagnosing scleroderma. However, they are not always positive in scleroderma. C3 and C4 can be low in lupus, especially if the disease is active. ...Read more

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Ana positive1.810 with a homogenous pattern what does this mean? What could i have? Few family members have lupus 1 scleroderma

Ana positive1.810 with a homogenous pattern what does this mean? What could i have? Few family members have lupus 1 scleroderma

See below: Your doctor will have to interpret the ANA in context to your symptoms. With you having a family history of autoimmune disease, you are at increased risk for developing one. However; false positive ANA can occur and we also know that a person who has family history of autoimmune disease may test positive for ana, but may never develop an autoimmune disease. It would be best to see a rheum dr. ...Read more

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I have lupus and scleroderma and now I'm being tested for osteonucrosis but it doesn't explain the pain I have everyday in my head, neck and back.

I have lupus and scleroderma and now I'm being tested for osteonucrosis but it doesn't explain the pain I have everyday in  my head, neck and back.

See ortho: I presume you are already under the care of a rheumatologist. If you cannot get an answer from him, either get a 2nd opinion or consult an orthopedist. Having autoimmune disorders does not preclude you from getting the usually bone issues. ...Read more

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What is the differentiation between scleroderma and drug induced lupus, have markers for both?

What is the differentiation between scleroderma and drug induced lupus, have markers for both?

Much different!: First, your clinical sx are more important than the labs. Drug-induced sle is characterized by single-strand anti-da abs. Markers for possible pss include scl-70 and centromere antibodies. But where you on a drug which commonly caused drug-induced sle. What are your symptoms: fever, joint pain, pleuritis, pericarditis? Or do you have raynaud's, swallowing probs, etc. See a rheumatology expert! ...Read more

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How does plaquinil slow the process of scleroderma and lupus? Or any autoimmune disease

See below: There is has been much on how exactly it works but it is thought to work on tlrs or toll-like receptors which play a role in the immune system. ...Read more

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Dr. Pierre Moeser
177 doctors shared insights

Scleroderma (Definition)

Scleroderma is an autoimmune disease characterized by tightening of the skin on ...Read more