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Doctor insights on: Difference Between Lupus And Scleroderma

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Can you get scleroderma and lupus?

Can you get scleroderma and lupus?

Mixed Picture: It would be very rare (but not impossible) to truly have both diseases together. It would be more likely to develop a so-called "overlap syndrome" in which you have a single autoimmune disorder that seems to borrow some features from each of these classic diseases without truly being purely one or purely the other. ...Read more

Dr. Pierre Moeser
182 doctors shared insights

Scleroderma (Definition)

An autoimmune disease in which there is excessive thickening of the connective tissues. This can cause skin tightening, rash, difficulty swallowing, and in severe cases affect ...Read more


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Does low c3c and 4 go with lupus rather than scleroderma?

Yes: Serum complements are normal in scleroderma but may be depressed in lupus. However, i would caution against putting too much importance on c3 and c4 levels as a diagnostic tool. They alone do not determine which disease is present. ...Read more

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Which symptoms 1st appear in someone with lupus or scleroderma?

Which symptoms 1st appear in someone with lupus or scleroderma?

It depends: There are several different symptoms that can appear, but it all depends on the patient. ...Read more

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Is low c3c and low c4c more indicative of lupus than scleroderma?

Is low c3c and low c4c more indicative of lupus than scleroderma?

Yes: Complement C3 and C4 are not indicators of scleroderma. Markers such as the centromere and the Scl-70 antibodies can be helpful in diagnosing scleroderma. However, they are not always positive in scleroderma. C3 and C4 can be low in lupus, especially if the disease is active. ...Read more

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Ana positive1.810 with a homogenous pattern what does this mean? What could i have? Few family members have lupus 1 scleroderma

Ana positive1.810 with a homogenous pattern what does this mean? What could i have? Few family members have lupus 1 scleroderma

See below: Your doctor will have to interpret the ANA in context to your symptoms. With you having a family history of autoimmune disease, you are at increased risk for developing one. However; false positive ANA can occur and we also know that a person who has family history of autoimmune disease may test positive for ana, but may never develop an autoimmune disease. It would be best to see a rheum dr. ...Read more

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I have lupus and scleroderma and now I'm being tested for osteonucrosis but it doesn't explain the pain I have everyday in my head, neck and back.

I have lupus and scleroderma and now I'm being tested for osteonucrosis but it doesn't explain the pain I have everyday in  my head, neck and back.

See ortho: I presume you are already under the care of a rheumatologist. If you cannot get an answer from him, either get a 2nd opinion or consult an orthopedist. Having autoimmune disorders does not preclude you from getting the usually bone issues. ...Read more

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What is the differentiation between scleroderma and drug induced lupus, have markers for both?

What is the differentiation between scleroderma and drug induced lupus, have markers for both?

Much different!: First, your clinical sx are more important than the labs. Drug-induced sle is characterized by single-strand anti-da abs. Markers for possible pss include scl-70 and centromere antibodies. But where you on a drug which commonly caused drug-induced sle. What are your symptoms: fever, joint pain, pleuritis, pericarditis? Or do you have raynaud's, swallowing probs, etc. See a rheumatology expert! ...Read more

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How does plaquinil slow the process of scleroderma and lupus? Or any autoimmune disease

See below: There is has been much on how exactly it works but it is thought to work on tlrs or toll-like receptors which play a role in the immune system. ...Read more

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Do you think all connective tissue diseases (lupus, sjogrens, scleroderma) are more alike than doctors realize since they tend to overlap so much?

Yes and no: Autoimmune diseases are all as different as the people who get them. These conditions all result from the body's immune system attacking different parts of your cells and tissues. Each person's disease will reflect the tissues that are being damaged. It is likely that everyone who has one of these conditions has a different spectrum of tissue damage which may be similar in some ways.. ...Read more

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I have a positive ANA 1:640 homogenous nuclear staining. Does this mean scleroderma or lupus? I also have a very slightly elevated angiotensin conv en

Depends: No diagnosis can be firmly established with a single blood test even in your case. Bone pain is not the usual manifestation of an autoimmune disease. Why was the test ordered in the first place? If your doctor suspects the presence of an autoimmune disorder , more tests will be needed to pin down the diagnosis. ...Read more

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I have lupus- diagnosed w/labs and symptoms.But had no antibodies positive- all were 0 except my ssa was 8 (0-40 is neg) & scl-70 was 3 (0-40 neg) should I be concerned about scleroderma? Very scared!

Rheumatologist. ...: You need to see a rheumatologist to sort out the lupus question. Lots of symptoms but zero lab evidence may not necessarily be lupus. Make sure diagnosis is right! ...Read more

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What is the best climate for me. I have lupus scleroderma RA fibromyalgia and crest syndrome ?

What is the best climate for me. I have lupus scleroderma RA fibromyalgia and crest syndrome ?

The Mighty Vitamin D: You may do better in warmer climate closer tot he equator for 2 reasons: more vitamin D and more exercise . Receiving more sunlight would naturally raise your vitamin D levels. Adequate vitamin D is essential for fibromyalgia relief, and is a powerful anti-inflammatory.More exercise, especially light walking or yoga on the beach would add to the benefit of vitamin D. ...Read more

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Pos ANA 1:640 homogenous nuclear staining. Normal C3 and c4. What is going on? Most likely lupus? Scleroderma? Had slightly elevated ACE test.

Pos ANA 1:640 homogenous nuclear staining. Normal C3 and c4. What is going on? Most likely lupus? Scleroderma? Had slightly elevated ACE test.

Abnormal ana: There are a lot of rheumatologic or autoimmune causes for an elevate ana. You would have to corelate this with the clinical findings. Additional testing might be needed to confirm the diagnosis. I recommend discussing this with your pcp. ...Read more

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Does family history in first cousin (or other NON-first-degree relatives) increase risk for autoimmune diseases such as lupus, scleroderma, RA?

Does family history in first cousin (or other NON-first-degree relatives) increase risk for autoimmune diseases such as lupus, scleroderma, RA?

Yes: If you have autoimmune disease in your family - you are at increase risk to also develop Autoimmune diseases also seem to have a genetic component, but, mysteriously, they can cluster in families as different illnesses. For example, a mother may have lupus erythematosus; her daughter, diabetes; her grandmother, rheumatoid arthritis. Research is shedding light on genetic, as well as hormonal and environmental risk factors that contribute to the causes of these diseases. ...Read more

Dr. Bernard Seif
140 doctors shared insights

Dermatosclerosis (Definition)

Dermatosclerosis = scleroderma = autoimmune disease affecting connective tissue & blood vessels. It causes skin to thicken asymmetrically due to deposits of fibrous connective ...Read more