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Diabetes Insipidus Water Deprivation Test
During fluid deprivation test, the ADH level dropped down to 1/3 of pre test level and below reference values. Is that a sign of diabetes insipidus?
Not necessarily: The most important thing to be following in a water deprivation test is the urine and serum osmolality. If the serum osmolality rises above normal, but the urine osmolality does not rise significantly, you have diabetes insipidus. Measuring ADH levels can be unreliable. ...Read more
Presistent increased frequency of emptying bladder, urinating, as a symptom of a disease state. 2 types: Mellitus (high blood glucose) & Insipidus (inadequate anti-diuretic hormone). In Diabetes mellitus, the far more common, glucose concentrations are ↑ed due to combination of 8 organ system changes referred to as the "ominous octet" & aggravated by intake of sugars (simple & complex ...Read more
Vasopressin test.: This is a dehydration test for diabetes insipidus. First, fluid is withheld until urine osmolality is stable. Then 5 u of vasopressin is given by subcutaneous injection. The urine and plasma osmolality/concentration is measures before and one hour after the injection. Argenine vasopressin or avp given to these patients causes a >9% rise in urine osmolality. In normal patients, it is <9%. ...Read more
Dx'd w/partial idiopathic central diabetes insipidus 20yrs ago by H20deprivation test. Put on DDAVP. No longer needed DDAVP after 2 yrs.Sx better.Why?
Central DI: Hard to answer. It was called "idiopathic", meaning no clear cause. In a 13 yr old, the causes could include a tumor, certain medications, trauma/surgery, meningitis, etc. It is possible that something happened back then but then resolved. Is it possible that you now still have partial DI? Under usual conditions, don't need DDAVP, but under water stress you may. See your Endocrinologist. ...Read more
Missing ADH: Anti diuretic hormone helps concentrate the urine to keep the body's sodium and water levels balanced. If the brain does not make enough ADH or of the kidney ignores the adh, a person can urinate too much dilute urine, becoming hypernatremic (high sodium) and dehydrated. Can be genetic, due to head trauma, brain tumor, infection, anorexia, idiopathic. ...Read moreSee 1 more doctor answer
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