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Doctor insights on: Diabetes And Lactic Acidosis

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Dr. Thomas Namey
37 doctors shared insights

Lactic Acidosis (Definition)

Lactic acidosis is the buildup of lactic acid in the blood, either from an increase in the body's production or the kidney being unable to remove lactic acid effectively. The most common causes are intense exercise (increased production of lactic acid) or kidney failure (unable to effectively remove lactic acid from blood). Other causes include blood infections (sepsis) and inability to ...Read more


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Respiratory acidosis and metabolic acidosis, which is worse?

Respiratory acidosis and metabolic acidosis, which is worse?

Worse acidosis: Both a respiratory (r) and metabolic acidosis (m) are bad. A r is due to retention of carbon dioxide (c) and a m is due to the presence of an organic acid. The treatment of a r is to reduce the c, blowing of c and the treatment of a m is to get rid of of the organic acid. ...Read more

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How can diabetic ketoacidosis (w/ metabolic acidosis) causes respiratory failure?

How can diabetic ketoacidosis (w/ metabolic acidosis) causes respiratory failure?

Due to acidosis.,,: The metabolic acidosis causes a respiratory compensation in an attempt by the body to keep the blood ph normal. The respiratory compensation is to increase minute ventilation (both respiratory rate and volume per breath!). So, the person with severe metabolic acidosis will be breathing fast and deeply. Doing this for an extended period of time can lead to fatigue resulting in respiratory failure. ...Read more

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How are respiratory acidosis and metabolic acidosis different?

The source: Respiratory acidosis is the result of co2 build up in the blood, metabolic acidosis is the result of inability to remove acids or the addition of acids to the system. ...Read more

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What causes diabetic keto acidosis?

Dka: Diabetic ketoacidosis is a condition whereby glucose which is used by cells for energy is not made available to the cells due to a lack of insulin. The lack of Insulin causes a dramatic rise in blood sugar triggering a host of meatbolic derangemants including dehydration as well as the production of ketones which are toxic as it raises the bodies acid level and will affect potassium levels. ...Read more

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How common is lactic acidosis with sepsis?

How common is lactic acidosis with sepsis?

With septic shock: It is a marker for end organ damage due to inadequate oxygen reception or utilization. When sepsis progresses to shock we will follow lactate (its pka is 4, so its never really acid in the blood) as a marker of our success in getting blood and oxygen to the peripheral tissues. So... In sepsis itself (without shock) it is rare, but in septic shock lactate is almost always elevated. ...Read more

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Does food change lactic acidosis levels?

Yes: Many foods are acidic in nature and so anything acidic can make an acidosis worse. Alkaline diets (increasing avocado, kale, spinach, cucumber, celery for example) can help balance and acidic condition. Meats are very acidic, by the way. ...Read more

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Why does the serum potassium level increase with diabetes ketoacidosis?

Why does the serum potassium level increase with diabetes ketoacidosis?

High potassium: Diabetic ketoacidosis (DKA) increases potassium (K) levels due to the acidosis (A) seen in DKA. A causes K to leave the cells and go into the blood. As DKA is treated, the A resolves, increasing the pH of the blood, so K goes back into the cells lowering the blood K level. ...Read more

Dr. Ayo Adu Dr. Adu
1 doctor agreed:
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What's lactic acidosis?

Dr. Ayo Adu Dr. Adu
1 doctor agreed:

Lactate + low pH: Lowered ph in your blood accompanied with a build-up of lactate. ...Read more

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Can taking one Metaformin cause lactic acidosis?

Unlikely: Theoretically Metformin can cause lactic acidosis but in setting of normal kidney function it is extremely unlikely. Liver disease and concurrent alcohol use can also increase the risk. Talk to your health care provider if you have any of the above risk factors to determine the risk of lactic acidosis. ...Read more

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Can diarreah from Lactulose syrup lead to lactic acidosis?

Lactic acidosis: No, it washes ammonia from colon and helps constipation but do not take everyday for constipation ...Read more

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How does the renal system compensates for metabolic acidosis and alkalosis?

How does the renal system compensates for metabolic acidosis and alkalosis?

Slowly & effectively: In response to acidosis, the kidney increases reabsorbtion of bicarbonate (sodium bicarbonate) from the tubular fluid, secretes more hydrogen ions, and generate more bicarbonate (sodium bicarbonate). Ammoniagenesis leads to increased formation of the buffering compounds. In responses to alkalosis, the kidney excretes more bicarbonate (sodium bicarbonate), decreases hydrogen ion secretion, and lowers rates of glutamine metabolism and ammonium excretion. ...Read more

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Diabetes and ketosis a bad combo?

Diabetes and ketosis a bad combo?

No, unless ↓ insulin: Ketosis is just a state of burning fats. Since ? insulin, as in type 2 DM, promotes storage of ingested sugar as body fat, ?ing sugar intake both ?es Insulin output & body fat, helping turn the DM snowball around, thus ?ing need for medications, physician visits & the many DM complications. Sadly, many physicians scare people to avoid ketosis; perhaps helps their business but not their clients. ...Read more

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How does diabetes mellitus lead to diabetes ketoacidosis?

How does diabetes mellitus lead to diabetes ketoacidosis?

Sugar is the source : Sugar is the source of energy in the cells and if you dont have insulin, than glucose can not be used to produce energy.That makes body release a hormone which breaks down fat as an alternate source of energy, in this process there is production of ketones, too much ketones get in the blood and cause ketoacidosis it is more common in type 1 diabetes which is Insulin dependant, and if not enough insuli. ...Read more

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How does hypertension reduces renal excretion of uric acid and leading to secondary gout?

How does hypertension reduces renal excretion of uric acid and leading  to secondary gout?

Two ways: First hypertension can lead to chronic kidney disease which can cause hyperuricemia and gout. Second certain drugs used to treat hypertension such as diuretics and low dose Aspirin can cause hyperuricemia and gout. It is important to control hypertension as much as to control blood sugar in diabetes, and important to know you can not know how high your blood pressure is by how you feel .Measure! ...Read more

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35 yr old male. On 1500mg metformin xr and 100mg januvia for type 2 diabetes. Kidneys fine. Worried about lactic acidosis. Is it rare in my case?

Lactic acidosis : 35 M with DM II. On metformin &kanuvia worried about lactic acidosis. ANS: This is rare and would not worry about it unless you get very sick. Work on diet to decrease need for meds. Get BMI to <25 and all DM may go away. Discuss with team. ...Read more

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I'm scared to take Metaformin.I have PCOS and I'm pre diabetes because of it.What are the chances of lactic acidosis.Would I know if I had it?thanks

I'm scared to take Metaformin.I have PCOS and I'm pre diabetes because of it.What are the chances of lactic acidosis.Would I know if I had it?thanks

Metformin : Metformin is a commonly used and excellent drug for treatment of PCOS especially when associated with glucose intolerance/prediabetes. Lactic acid grosses is an uncommon side effect and when occurs is usually in elderly patients who may have kidney dysfunction. ...Read more

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I'm confused, what is lactic acidosis?

Dangerous condition: The body generates energy by breaking down fat and sugar thru a very efficient mechanism that uses oxygen and produces carbon dioxide and water. When this mechanism fails, there is another inefficient back up system that generates lactic acid. Poor blood flow, low oxygen, medications, poisons, excessive exercise can cause this lactic acidosis. It should be corrected promptly. ...Read more

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Can taking one Metaformin cause lactic acidosis?

Unlikely: Theoretically Metformin can cause lactic acidosis but in setting of normal kidney function it is extremely unlikely. Liver disease and concurrent alcohol use can also increase the risk. Talk to your health care provider if you have any of the above risk factors to determine the risk of lactic acidosis. ...Read more

Dr. Ayo Adu Dr. Adu
1 doctor agreed:
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What's lactic acidosis?

Dr. Ayo Adu Dr. Adu
1 doctor agreed:

Lactate + low pH: Lowered ph in your blood accompanied with a build-up of lactate. ...Read more

Acidosis (Definition)

Normally our body chemistry is kept in a narrow range, and in particular the amount of acid in the body is kept within a narrow range. The amount of acid is measured by a value called the ph. It is normally a value between 7.35 and 7.45, values below 7.35 are considered to be "acidotic" a patient with this value of the blood chemistry ...Read more


Dr. Quang Nguyen
3,456 doctors shared insights

Diabetes (Definition)

A group of diseases that result in too much sugar in the ...Read more